{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Proton+Pump+Inhibitor+%28PPI%29+Therapy&page=2",
    "query": {
      "intervention": "Proton Pump Inhibitor (PPI) Therapy",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 114,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Proton+Pump+Inhibitor+%28PPI%29+Therapy&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Proton+Pump+Inhibitor+%28PPI%29+Therapy&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-10T01:14:55.506Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03701555",
      "title": "A Study of PVP001, PVP002, and PVP003 in Healthy Adults and PVP001 and PVP002 in Adults With Celiac Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Digestive System Disease"
      ],
      "interventions": [
        {
          "name": "PvP001 placebo",
          "type": "OTHER"
        },
        {
          "name": "PvP001 100 mg",
          "type": "DRUG"
        },
        {
          "name": "PvP001 300 mg",
          "type": "DRUG"
        },
        {
          "name": "PvP001 900 mg",
          "type": "DRUG"
        },
        {
          "name": "Maximum Feasible Dose (MFD) of PvP002",
          "type": "DRUG"
        },
        {
          "name": "Maximum Tolerated Dose (MTD) of PvP001",
          "type": "DRUG"
        },
        {
          "name": "MTD of PvP001 following 7 days of PPI treatment",
          "type": "DRUG"
        },
        {
          "name": "PvP002 placebo",
          "type": "OTHER"
        },
        {
          "name": "PvP001 600 mg",
          "type": "DRUG"
        },
        {
          "name": "PvP003 placebo",
          "type": "DRUG"
        },
        {
          "name": "PvP003",
          "type": "DRUG"
        },
        {
          "name": "PvP003 150 mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Millennium Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 139,
      "start_date": "2018-06-19",
      "completion_date": "2021-07-02",
      "has_results": true,
      "last_update_posted_date": "2023-04-04",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "Anaheim, California",
      "locations": [
        {
          "city": "Anaheim",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03701555"
    },
    {
      "nct_id": "NCT05446142",
      "title": "A Relative Bioavailability Study Evaluating Two New Encorafenib Formulations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Encorafenib capsule formulation (CAP)",
          "type": "DRUG"
        },
        {
          "name": "Encorafenib first formulation",
          "type": "DRUG"
        },
        {
          "name": "Encorafenib second formulation",
          "type": "DRUG"
        },
        {
          "name": "Rabeprazole tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2022-07-01",
      "completion_date": "2022-09-30",
      "has_results": true,
      "last_update_posted_date": "2024-02-23",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05446142"
    },
    {
      "nct_id": "NCT05449444",
      "title": "Masitinib for the Treatment of Severe Mast Cell Activation Syndrome",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mast Cell Activation Syndrome"
      ],
      "interventions": [
        {
          "name": "Masitinib 4.5 mg/kg/day",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Best supportive care",
          "type": "OTHER"
        },
        {
          "name": "Masitinib 6.0 mg/kg/day",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "AB Science",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 72,
      "start_date": "2022-07-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-02-06",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "Weldon Spring, Missouri",
      "locations": [
        {
          "city": "Weldon Spring",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05449444"
    },
    {
      "nct_id": "NCT04435483",
      "title": "A Study of Acalabrutinib Suspension to Evaluate Relative Bioavailability and Proton-pump Inhibitor Effect in Healthy Volunteers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Pharmacokinetics",
        "Bioavailability"
      ],
      "interventions": [
        {
          "name": "Acalabrutinib Treatment A",
          "type": "DRUG"
        },
        {
          "name": "Acalabrutinib Treatment B",
          "type": "DRUG"
        },
        {
          "name": "Acalabrutinib Treatment C",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "AstraZeneca",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 39,
      "start_date": "2020-05-22",
      "completion_date": "2020-06-26",
      "has_results": false,
      "last_update_posted_date": "2020-07-22",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "Glendale, California",
      "locations": [
        {
          "city": "Glendale",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04435483"
    },
    {
      "nct_id": "NCT07563894",
      "title": "Relative Bioavailability and Impact of Rabeprazole for PF-07799933, Food-Effect for PF-07799933 and PF-07799544",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "PF-07799933 tablets with PF-07799544 fasted",
          "type": "DRUG"
        },
        {
          "name": "PF-07799933 film-coated tablets with PF-07799544 fasted",
          "type": "DRUG"
        },
        {
          "name": "PF-07799933 film-coated tablets with PF-07799544 fed",
          "type": "DRUG"
        },
        {
          "name": "PF-07799933 film-coated tablets fasted",
          "type": "DRUG"
        },
        {
          "name": "PF-07799933 film-coated tablets following rabeprazole pretreatment fasted",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 16,
      "start_date": "2026-04-10",
      "completion_date": "2026-06-26",
      "has_results": false,
      "last_update_posted_date": "2026-07-09",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07563894"
    },
    {
      "nct_id": "NCT06999577",
      "title": "The Mechanism Versus PPI Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Laryngopharyngeal Reflux",
        "Cough",
        "Throat Clearing",
        "Dysphonia",
        "Reflux"
      ],
      "interventions": [
        {
          "name": "Omeprazole 40 MG",
          "type": "DRUG"
        },
        {
          "name": "Laryngeal Recalibration Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "GERD Lifestyle Recommendations",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 160,
      "start_date": "2025-06-04",
      "completion_date": "2029-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-08-01",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "San Deigo, California",
      "locations": [
        {
          "city": "San Deigo",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06999577"
    },
    {
      "nct_id": "NCT01724606",
      "title": "Whole Brain Radiotherapy (WBRT) With Sorafenib for Breast Cancer Brain Metastases (BCBM)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Breast Cancer",
        "Brain Metastases"
      ],
      "interventions": [
        {
          "name": "Whole Brain Radiotherapy (WBRT)",
          "type": "RADIATION"
        },
        {
          "name": "Sorafenib",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "RADIATION",
        "DRUG"
      ],
      "sponsor": "Memorial Sloan Kettering Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2012-11-05",
      "completion_date": "2022-03-01",
      "has_results": false,
      "last_update_posted_date": "2022-03-07",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 6,
      "location_summary": "Basking Ridge, New Jersey • Middletown, New Jersey • Commack, New York + 3 more",
      "locations": [
        {
          "city": "Basking Ridge",
          "state": "New Jersey"
        },
        {
          "city": "Middletown",
          "state": "New Jersey"
        },
        {
          "city": "Commack",
          "state": "New York"
        },
        {
          "city": "Harrison",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01724606"
    },
    {
      "nct_id": "NCT03619811",
      "title": "Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gastroesophageal Reflux",
        "Laryngopharyngeal Reflux"
      ],
      "interventions": [
        {
          "name": "Reflux Band® Upper Esophageal Sphincter (UES) Assist Device",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 43,
      "start_date": "2018-07-13",
      "completion_date": "2021-06-30",
      "has_results": true,
      "last_update_posted_date": "2021-09-20",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03619811"
    },
    {
      "nct_id": "NCT00251732",
      "title": "Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Gastroesophageal Reflux Disease"
      ],
      "interventions": [
        {
          "name": "Standard dose (once daily) PPI plus low-dose antidepressant",
          "type": "DRUG"
        },
        {
          "name": "Double dose PPI plus evening placebo",
          "type": "DRUG"
        },
        {
          "name": "Rabeprazole , placebo, placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Arizona",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 150,
      "start_date": "2005-03",
      "completion_date": "2010-05",
      "has_results": false,
      "last_update_posted_date": "2010-08-19",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "Tucson, Arizona",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00251732"
    },
    {
      "nct_id": "NCT01822977",
      "title": "The Impact of Proton Pump Inhibitors on the Fecal Microbiome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy",
        "Clostridium Difficile Infection"
      ],
      "interventions": [
        {
          "name": "omeprazole",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2013-03",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2014-08-20",
      "last_synced_at": "2026-10-10T01:14:55.506Z",
      "location_count": 1,
      "location_summary": "Scottsdale, Arizona",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01822977"
    }
  ]
}