{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pycnogenol",
    "query": {
      "intervention": "Pycnogenol"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 15,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pycnogenol&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T03:31:55.676Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02909686",
      "title": "Effects of Botanical Microglia Modulators in Gulf War Illness",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gulf War Illness"
      ],
      "interventions": [
        {
          "name": "Boswellia Serrata",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Curcumin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Epimedium",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Fisetin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Luteolin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Nettle",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Pycnogenol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Reishi Mushroom",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Resveratrol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "39 Years",
        "maximum_age": "65 Years",
        "sex": "MALE",
        "summary": "39 Years to 65 Years · Male only"
      },
      "enrollment_count": 36,
      "start_date": "2016-07",
      "completion_date": "2022-09",
      "has_results": true,
      "last_update_posted_date": "2025-01-24",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02909686"
    },
    {
      "nct_id": "NCT03866005",
      "title": "Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Center-involved Diabetic Macular Edema (CI-DME)"
      ],
      "interventions": [
        {
          "name": "Diabetes Visual Function Study (DiVFuSS) softgels",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "canola oil placebo softgels, 2 per day",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "ZeaVision, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 150,
      "start_date": "2019-11-01",
      "completion_date": "2021-11-01",
      "has_results": false,
      "last_update_posted_date": "2020-07-02",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 2,
      "location_summary": "Olympia, Washington • Tacoma, Washington",
      "locations": [
        {
          "city": "Olympia",
          "state": "Washington"
        },
        {
          "city": "Tacoma",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03866005"
    },
    {
      "nct_id": "NCT04024033",
      "title": "Effects of Pine Cone Extract on Serum IgE Levels in Perennial Rhinitis",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Perennial Allergic Rhinitis"
      ],
      "interventions": [
        {
          "name": "pine cone extract",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 36,
      "start_date": "2011-03",
      "completion_date": "2023-10",
      "has_results": false,
      "last_update_posted_date": "2023-05-10",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04024033"
    },
    {
      "nct_id": "NCT00214032",
      "title": "Pycnogenol for the Treatment of Lymphedema",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lymphedema"
      ],
      "interventions": [
        {
          "name": "Pycnogenol",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 2,
      "start_date": "2002-05",
      "completion_date": "2007-01",
      "has_results": false,
      "last_update_posted_date": "2015-10-05",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00214032"
    },
    {
      "nct_id": "NCT00952627",
      "title": "Effects of Pycnogenol on Cardiac Fibrosis and Diastolic Dysfunction in Aged Hypertensive Subjects",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cardiac Fibrosis",
        "Diastolic Dysfunction"
      ],
      "interventions": [
        {
          "name": "Pycnogenol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Arizona",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "50 Years to 75 Years"
      },
      "enrollment_count": 9,
      "start_date": "2009-07",
      "completion_date": "2011-07",
      "has_results": false,
      "last_update_posted_date": "2013-12-17",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Tucson, Arizona",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00952627"
    },
    {
      "nct_id": "NCT00425945",
      "title": "Understanding Pine Bark Extract as an Alternative Treatment (UPBEAT) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Pine Bark Extract (Flavangenol®)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 130,
      "start_date": "2006-10",
      "completion_date": "2008-08",
      "has_results": true,
      "last_update_posted_date": "2014-04-02",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00425945"
    },
    {
      "nct_id": "NCT03704454",
      "title": "The Use of Pycnogenol® to Alleviate Menopausal Symptoms Induced or Increased by Breast and Gynecological Cancer Treatments",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Climacteric; Menorrhagia, Menopausal",
        "Menopause"
      ],
      "interventions": [
        {
          "name": "50 mg PYC and then placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "100 mg PYC and then placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo and then 50 mg PYC",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo and then 100 mg PYC",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Legacy Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 99 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2018-10-01",
      "completion_date": "2020-09-15",
      "has_results": false,
      "last_update_posted_date": "2018-10-12",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 3,
      "location_summary": "Gresham, Oregon • Portland, Oregon • Tualatin, Oregon",
      "locations": [
        {
          "city": "Gresham",
          "state": "Oregon"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Tualatin",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03704454"
    },
    {
      "nct_id": "NCT00064857",
      "title": "Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lymphedema",
        "Breast",
        "Cancer"
      ],
      "interventions": [
        {
          "name": "Pycnogenol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Center for Complementary and Integrative Health (NCCIH)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2003-08",
      "completion_date": "2007-08",
      "has_results": false,
      "last_update_posted_date": "2008-04-22",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00064857"
    },
    {
      "nct_id": "NCT02566980",
      "title": "Biological Triggers of Depression in Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Depression and Suicide",
        "Mood Disorders",
        "Other Perinatal Conditions"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Michigan State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 209,
      "start_date": "2014-10-23",
      "completion_date": "2017-02-28",
      "has_results": false,
      "last_update_posted_date": "2018-06-28",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 3,
      "location_summary": "Grand Rapids, Michigan",
      "locations": [
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        },
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        },
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02566980"
    },
    {
      "nct_id": "NCT05824351",
      "title": "LowCostomy: Dedicated Toward Creating a High-quality, Low-cost Colostomy Appliance for Those in Sub-Saharan Africa",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Abdominal Site",
        "Colostomy Site"
      ],
      "interventions": [
        {
          "name": "Tanzanian beeswax-pine resin",
          "type": "DEVICE"
        },
        {
          "name": "Domestic beeswax-pine resin",
          "type": "DEVICE"
        },
        {
          "name": "Hollister's AdaptTM Barrier Rings",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2023-06-10",
      "completion_date": "2023-06-23",
      "has_results": true,
      "last_update_posted_date": "2024-09-26",
      "last_synced_at": "2026-09-06T03:31:55.676Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05824351"
    }
  ]
}