{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=RO4917838", "query": { "intervention": "RO4917838" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 16, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=RO4917838&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-02T19:22:32.465Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01235520", "title": "A Study of RO4917838 in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (NN25307)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "RO4917838", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 595, "start_date": "2011-01", "completion_date": "2014-07", "has_results": false, "last_update_posted_date": "2015-06-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 30, "location_summary": "Little Rock, Arkansas • Buena Park, California • Cerritos, California + 24 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Buena Park", "state": "California" }, { "city": "Cerritos", "state": "California" }, { "city": "Downey", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01235520" }, { "nct_id": "NCT01438749", "title": "A Study of The Abuse Liability Potential of RO4917838 in Recreational Drug Users", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteer" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "RO4917838", "type": "DRUG" }, { "name": "diazepam", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 177, "start_date": "2011-10", "completion_date": "2012-05", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT01438749" }, { "nct_id": "NCT01192867", "title": "A Study of RO4917838 in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "RO4917838", "type": "DRUG" }, { "name": "Antipshychotics (Standard of Care)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 629, "start_date": "2010-12-11", "completion_date": "2014-05-26", "has_results": false, "last_update_posted_date": "2017-06-26", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 27, "location_summary": "Little Rock, Arkansas • Anaheim, California • Cerritos, California + 23 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Cerritos", "state": "California" }, { "city": "Downey", "state": "California" }, { "city": "La Palma", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01192867" }, { "nct_id": "NCT05308472", "title": "Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Erythropoietic Protoporphyria" ], "interventions": [ { "name": "DISC-1459", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Disc Medicine, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 75, "start_date": "2022-10-31", "completion_date": "2024-08-23", "has_results": true, "last_update_posted_date": "2026-01-08", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 9, "location_summary": "Birmingham, Alabama • San Francisco, California • Miami, Florida + 6 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Francisco", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05308472" }, { "nct_id": "NCT06910358", "title": "Study of Bitopertin in Participants With EPP or XLP (APOLLO)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Erythropoietic Protoporphyria (EPP)", "X-Linked Protoporphyria (XLP)" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "DISC-1459", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Disc Medicine, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 183, "start_date": "2025-04-04", "completion_date": "2026-10", "has_results": false, "last_update_posted_date": "2026-09-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 11, "location_summary": "Huntington Beach, California • San Francisco, California • Miami, Florida + 7 more", "locations": [ { "city": "Huntington Beach", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06910358" }, { "nct_id": "NCT01192906", "title": "A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25309)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "bitopertin [RO4917838]", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 624, "start_date": "2010-12", "completion_date": "2014-07", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 21, "location_summary": "Carson, California • Oceanside, California • San Diego, California + 17 more", "locations": [ { "city": "Carson", "state": "California" }, { "city": "Oceanside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Hartford", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT01192906" }, { "nct_id": "NCT01674361", "title": "A Study of Bitopertin (RO4917838) in Combination With Selective Serotonin Reuptake Inhibitors (SSRIs) in Participants With Obsessive-Compulsive Disorder (OCD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Obsessive-Compulsive Disorder" ], "interventions": [ { "name": "Bitopertin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "SSRI", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 99, "start_date": "2012-12-31", "completion_date": "2015-04-30", "has_results": false, "last_update_posted_date": "2017-08-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 27, "location_summary": "Oceanside, California • Stanford, California • New Haven, Connecticut + 22 more", "locations": [ { "city": "Oceanside", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Leesburg", "state": "Florida" }, { "city": "Orange City", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01674361" }, { "nct_id": "NCT01235585", "title": "A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25306)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "bitopertin [RO4917838]", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 597, "start_date": "2010-12", "completion_date": "2014-09", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 25, "location_summary": "Carson, California • Garden Grove, California • Long Beach, California + 19 more", "locations": [ { "city": "Carson", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Oceanside", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01235585" }, { "nct_id": "NCT01116830", "title": "A Study of the Effect of RO4917838 on Biomarker Measures of Cognitive Dysfunction in Participants With Schizophrenia and Schizoaffective Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "RO4917838", "type": "DRUG" }, { "name": "Standard Antipsychotic Therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 29, "start_date": "2010-11", "completion_date": "2014-02", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 1, "location_summary": "Orangeburg, New York", "locations": [ { "city": "Orangeburg", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01116830" }, { "nct_id": "NCT05883748", "title": "HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Erythropoietic Protoporphyria" ], "interventions": [ { "name": "DISC-1459", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Disc Medicine, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 230, "start_date": "2023-08-31", "completion_date": "2028-06", "has_results": false, "last_update_posted_date": "2026-09-02", "last_synced_at": "2026-09-02T19:22:32.465Z", "location_count": 11, "location_summary": "Birmingham, Alabama • San Francisco, California • Miami, Florida + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Francisco", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05883748" } ] }