{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Recombinant+S+protein+SARS+vaccine", "query": { "intervention": "Recombinant S protein SARS vaccine" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 18, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Recombinant+S+protein+SARS+vaccine&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-01T15:02:43.572Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05000216", "title": "COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis (RA)", "Systemic Lupus Erythematosus (SLE)", "Pemphigus Vulgaris", "Multiple Sclerosis (MS)", "Systemic Sclerosis (SSc)", "Pediatric SLE", "Juvenile Idiopathic Arthritis (JIA)", "Juvenile Dermatomyositis (JDM)", "Pediatric-Onset Multiple Sclerosis (POMS)" ], "interventions": [ { "name": "Moderna mRNA-1273", "type": "BIOLOGICAL" }, { "name": "BNT162b2", "type": "BIOLOGICAL" }, { "name": "Ad26.COV2.S", "type": "BIOLOGICAL" }, { "name": "Continue IS (MMF or MPA)", "type": "DRUG" }, { "name": "Continue IS (MTX)", "type": "DRUG" }, { "name": "Continue IS (B cell depletion therapy)", "type": "BIOLOGICAL" }, { "name": "Monovalent [B.1.351] CoV2 preS dTM-AS03", "type": "BIOLOGICAL" }, { "name": "Withhold IS (MMF or MPA)", "type": "DRUG" }, { "name": "Withhold IS (MTX)", "type": "DRUG" }, { "name": "Withhold IS (B cell depletion therapy)", "type": "DRUG" }, { "name": "Moderna mRNA-1273, Bivalent", "type": "BIOLOGICAL" }, { "name": "BNT162b2, Bivalent", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": null, "sex": "ALL", "summary": "2 Years and older" }, "enrollment_count": 258, "start_date": "2021-08-13", "completion_date": "2024-03-28", "has_results": true, "last_update_posted_date": "2026-06-10", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 29, "location_summary": "Los Angeles, California • New Haven, Connecticut • Atlanta, Georgia + 18 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05000216" }, { "nct_id": "NCT06742281", "title": "A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "CVXGA (CVXGA50)", "type": "BIOLOGICAL" }, { "name": "COMIRNATY®", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CyanVac LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 432, "start_date": "2024-12-05", "completion_date": "2026-06-15", "has_results": false, "last_update_posted_date": "2026-07-10", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 55, "location_summary": "Anniston, Alabama • Phoenix, Arizona • Chula Vista, California + 44 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Chula Vista", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "La Palma", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06742281" }, { "nct_id": "NCT05736835", "title": "A Phase 2 Trial of the Immunogenicity and Safety of CVXGA Intranasal COVID Vaccine in Healthy Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "CVXGA", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CyanVac LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 227, "start_date": "2023-09-21", "completion_date": "2025-12-16", "has_results": false, "last_update_posted_date": "2026-07-14", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 10, "location_summary": "San Diego, California • Boise, Idaho • Sioux City, Iowa + 7 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Boise", "state": "Idaho" }, { "city": "Sioux City", "state": "Iowa" }, { "city": "Rockville", "state": "Maryland" }, { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT05736835" }, { "nct_id": "NCT04811664", "title": "A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vaccine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "SARS-CoV-2 Infection" ], "interventions": [ { "name": "Moderna COVID-19 Vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "29 Years", "sex": "ALL", "summary": "18 Years to 29 Years" }, "enrollment_count": 1923, "start_date": "2021-03-24", "completion_date": "2021-12-30", "has_results": true, "last_update_posted_date": "2023-08-02", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 51, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Tempe, Arizona + 45 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04811664" }, { "nct_id": "NCT04889209", "title": "Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Ad26.COV2.S", "type": "BIOLOGICAL" }, { "name": "BNT162b2", "type": "BIOLOGICAL" }, { "name": "mRNA-1273", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.211", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.222", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 rS/M1", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 867, "start_date": "2021-05-28", "completion_date": "2023-06-16", "has_results": true, "last_update_posted_date": "2025-04-20", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 10, "location_summary": "Decatur, Georgia • Baltimore, Maryland • New York, New York + 6 more", "locations": [ { "city": "Decatur", "state": "Georgia" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "New York", "state": "New York" }, { "city": "Rochester", "state": "New York" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04889209" }, { "nct_id": "NCT07730450", "title": "A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "COVID-19 Vaccines" ], "interventions": [ { "name": "BNT162b2 Vaccine", "type": "BIOLOGICAL" }, { "name": "Tdap Vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "BioNTech SE", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 200, "start_date": "2026-07-23", "completion_date": "2027-08-20", "has_results": false, "last_update_posted_date": "2026-08-07", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 5, "location_summary": "Walnut Creek, California • Miami Lakes, Florida • Honolulu, Hawaii + 2 more", "locations": [ { "city": "Walnut Creek", "state": "California" }, { "city": "Miami Lakes", "state": "Florida" }, { "city": "Honolulu", "state": "Hawaii" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT07730450" }, { "nct_id": "NCT05293665", "title": "Platform Trial to Compare Homologous Boost of Authorized COVID-19 Vaccines and Heterologous Boost With UB-612 Vaccine", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "COVID-19 Vaccines" ], "interventions": [ { "name": "UB-612", "type": "BIOLOGICAL" }, { "name": "BNT162b2 vaccine", "type": "BIOLOGICAL" }, { "name": "ChAdOx1-S vaccine", "type": "BIOLOGICAL" }, { "name": "Sinopharm BIBP", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Vaxxinity, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 944, "start_date": "2022-03-16", "completion_date": "2023-09", "has_results": false, "last_update_posted_date": "2022-10-14", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 1, "location_summary": "Brownsville, Texas", "locations": [ { "city": "Brownsville", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05293665" }, { "nct_id": "NCT05016622", "title": "Booster Dose Trial", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cancer" ], "interventions": [ { "name": "BNT162b2 vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Montefiore Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 106, "start_date": "2021-08-10", "completion_date": "2023-05-21", "has_results": true, "last_update_posted_date": "2024-07-31", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 1, "location_summary": "The Bronx, New York", "locations": [ { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05016622" }, { "nct_id": "NCT04468958", "title": "Safety, Tolerability, and Pharmacokinetics of SAB-185 in Healthy Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "COVID-19", "SARS-CoV2" ], "interventions": [ { "name": "SAB-185", "type": "BIOLOGICAL" }, { "name": "Normal saline", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "SAb Biotherapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 28, "start_date": "2020-07-01", "completion_date": "2020-12-23", "has_results": false, "last_update_posted_date": "2022-07-01", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 3, "location_summary": "Wichita, Kansas • Syracuse, New York • San Antonio, Texas", "locations": [ { "city": "Wichita", "state": "Kansas" }, { "city": "Syracuse", "state": "New York" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04468958" }, { "nct_id": "NCT01376765", "title": "Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "SARS" ], "interventions": [ { "name": "Aluminum hydroxide adjuvant (Alhydrogel®)", "type": "DRUG" }, { "name": "Phosphate buffered saline Placebo", "type": "OTHER" }, { "name": "Recombinant S protein SARS vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "OTHER", "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "18 Years to 40 Years" }, "enrollment_count": 0, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2013-02-15", "last_synced_at": "2026-10-01T15:02:43.572Z", "location_count": 3, "location_summary": "Iowa City, Iowa • St Louis, Missouri • Cincinnati, Ohio", "locations": [ { "city": "Iowa City", "state": "Iowa" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01376765" } ] }