{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Reduced+Nicotine+Content+Cigarettes",
    "query": {
      "intervention": "Reduced Nicotine Content Cigarettes"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 38,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Reduced+Nicotine+Content+Cigarettes&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-19T03:11:11.428Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04740008",
      "title": "Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Smoking",
        "Cigarette"
      ],
      "interventions": [
        {
          "name": "Low Nicotine Content Cigarettes",
          "type": "DRUG"
        },
        {
          "name": "Control message",
          "type": "OTHER"
        },
        {
          "name": "Test message",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Masonic Cancer Center, University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2021-04-20",
      "completion_date": "2022-08-24",
      "has_results": false,
      "last_update_posted_date": "2024-02-26",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04740008"
    },
    {
      "nct_id": "NCT06614504",
      "title": "Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Varying the nicotine content of cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Varying the nicotine content of e-cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 308,
      "start_date": "2024-11-01",
      "completion_date": "2028-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-06-27",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island • Burlington, Vermont",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06614504"
    },
    {
      "nct_id": "NCT05370313",
      "title": "The Impact of Innovative Tax Proposals on Purchase Patterns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Market Price Condition (control)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Tobacco Parity Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine-Content Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Harm-Reduction Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Modified Risk Tobacco Product (MRTP) Tax Condition",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 285,
      "start_date": "2023-04-11",
      "completion_date": "2025-06-10",
      "has_results": false,
      "last_update_posted_date": "2025-09-18",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 2,
      "location_summary": "Buffalo, New York • Roanoke, Virginia",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05370313"
    },
    {
      "nct_id": "NCT02000921",
      "title": "Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Addiction",
        "Dual Tobacco Use"
      ],
      "interventions": [
        {
          "name": "VLNC cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Combusted Products",
          "type": "OTHER"
        },
        {
          "name": "Non-combusted products",
          "type": "OTHER"
        },
        {
          "name": "CN cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 136,
      "start_date": "2013-12",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2017-03-31",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02000921"
    },
    {
      "nct_id": "NCT02989038",
      "title": "Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Very Low Nicotine Content Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Intermediate Nicotine Content Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Normal Nicotine Content Cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "15 Years to 25 Years"
      },
      "enrollment_count": 182,
      "start_date": "2017-01",
      "completion_date": "2019-12-17",
      "has_results": false,
      "last_update_posted_date": "2020-03-04",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02989038"
    },
    {
      "nct_id": "NCT02592772",
      "title": "Manipulating Tobacco Constituents in Male Menthol Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Reduced Nicotine Non-Menthol (RNC)",
          "type": "OTHER"
        },
        {
          "name": "Reduced Nicotine Menthol (RNC-Men)",
          "type": "OTHER"
        },
        {
          "name": "Conventional Nicotine Non-Menthol (CN)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "18 Years to 45 Years · Male only"
      },
      "enrollment_count": 118,
      "start_date": "2016-02-04",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2020-04-09",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 2,
      "location_summary": "Farmington, Connecticut • Hartford, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02592772"
    },
    {
      "nct_id": "NCT02415270",
      "title": "Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Smoking Behavior"
      ],
      "interventions": [
        {
          "name": "Reduced Nicotine Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Reduced ROS/RNS",
          "type": "OTHER"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Milton S. Hershey Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 37,
      "start_date": "2016-01",
      "completion_date": "2017-01-01",
      "has_results": false,
      "last_update_posted_date": "2018-07-27",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Hershey, Pennsylvania",
      "locations": [
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02415270"
    },
    {
      "nct_id": "NCT02600273",
      "title": "Novel Approaches to Reducing Tobacco Related Harm",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Tobacco Smoking Behavior",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Usual brand cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Lower nicotine content cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Electronic cigarettes 1",
          "type": "OTHER"
        },
        {
          "name": "Electronic cigarettes 2",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2017-01",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2020-09-30",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02600273"
    },
    {
      "nct_id": "NCT04805515",
      "title": "Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence, Cigarettes"
      ],
      "interventions": [
        {
          "name": "Nicotine Corrective Messages",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 794,
      "start_date": "2021-02-12",
      "completion_date": "2021-05-31",
      "has_results": true,
      "last_update_posted_date": "2022-12-02",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04805515"
    },
    {
      "nct_id": "NCT03272685",
      "title": "Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Tobacco Smoking",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Very Low Nicotine Content Cigarettes",
          "type": "DRUG"
        },
        {
          "name": "Normal Nicotine Content Cigarettes",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 799,
      "start_date": "2018-06-01",
      "completion_date": "2023-01-10",
      "has_results": true,
      "last_update_posted_date": "2024-08-20",
      "last_synced_at": "2026-09-19T03:11:11.428Z",
      "location_count": 6,
      "location_summary": "San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03272685"
    }
  ]
}