{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Retinol+face+cream",
    "query": {
      "intervention": "Retinol face cream"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 8,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-09T12:31:09.913Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06658847",
      "title": "A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Retinoid",
        "Skin Aging",
        "Epigenomics"
      ],
      "interventions": [
        {
          "name": "Night Cream Usage",
          "type": "OTHER"
        },
        {
          "name": "No Night Cream Usage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "40 Years to 65 Years · Female only"
      },
      "enrollment_count": 66,
      "start_date": "2024-11-07",
      "completion_date": "2025-04-29",
      "has_results": false,
      "last_update_posted_date": "2025-06-17",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "High Point, North Carolina",
      "locations": [
        {
          "city": "High Point",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06658847"
    },
    {
      "nct_id": "NCT03878381",
      "title": "Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Skin Care"
      ],
      "interventions": [
        {
          "name": "Skin Care Cream",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "DRUG"
      ],
      "sponsor": "Wayne State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "20 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-04-01",
      "completion_date": "2022-10-29",
      "has_results": false,
      "last_update_posted_date": "2022-11-01",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Dearborn, Michigan",
      "locations": [
        {
          "city": "Dearborn",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03878381"
    },
    {
      "nct_id": "NCT02620813",
      "title": "De Novo Lipogenesis of Sebaceous Glands in Acne",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Acne Vulgaris"
      ],
      "interventions": [
        {
          "name": "Tretinoin",
          "type": "DRUG"
        },
        {
          "name": "Isotretinoin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "15 Years to 45 Years"
      },
      "enrollment_count": 32,
      "start_date": "2015-10",
      "completion_date": "2017-10-12",
      "has_results": false,
      "last_update_posted_date": "2021-08-05",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 2,
      "location_summary": "Davis, California • Sacramento, California",
      "locations": [
        {
          "city": "Davis",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02620813"
    },
    {
      "nct_id": "NCT04724473",
      "title": "A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Acne Vulgaris"
      ],
      "interventions": [
        {
          "name": "Tretinoin Cream 0.025%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sun Pharmaceutical Industries, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "12 Years to 40 Years"
      },
      "enrollment_count": 1030,
      "start_date": "2019-12-10",
      "completion_date": "2020-11-21",
      "has_results": false,
      "last_update_posted_date": "2021-04-01",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04724473"
    },
    {
      "nct_id": "NCT03427554",
      "title": "To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.1% and RLD in the Treatment of Acne Vulgaris",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Acne Vulgaris"
      ],
      "interventions": [
        {
          "name": "Tretinoin cream 0.1%",
          "type": "DRUG"
        },
        {
          "name": "RETIN-A® Cream",
          "type": "DRUG"
        },
        {
          "name": "Vehicle of the test product",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sun Pharmaceutical Industries, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "12 Years to 40 Years"
      },
      "enrollment_count": 455,
      "start_date": "2017-08-21",
      "completion_date": "2018-01-26",
      "has_results": false,
      "last_update_posted_date": "2018-05-18",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03427554"
    },
    {
      "nct_id": "NCT06125912",
      "title": "A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Aging"
      ],
      "interventions": [
        {
          "name": "Dime Beauty TBT Cream",
          "type": "OTHER"
        },
        {
          "name": "Positive Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Dime Beauty Co.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2023-09-25",
      "completion_date": "2024-02-15",
      "has_results": false,
      "last_update_posted_date": "2024-02-22",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Santa Monica, California",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06125912"
    },
    {
      "nct_id": "NCT05446402",
      "title": "Investigation of the Tolerability of Two Facial Cleansing Routines for Mild to Moderate Acne",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acne"
      ],
      "interventions": [
        {
          "name": "Geologie Acne Regimen - one side of face",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Proactive Acne Regimen - other side of face",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 29,
      "start_date": "2022-06-15",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-04-11",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05446402"
    },
    {
      "nct_id": "NCT05039476",
      "title": "Study to Identify if Chemist Confessions Retinol Cream Works to Improve the Appearance of Early Signs of Aging.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Aging"
      ],
      "interventions": [
        {
          "name": "Retinol face cream",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo face cream",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Chemist Confessions, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "30 Years to 50 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2022-07-01",
      "completion_date": "2022-11-30",
      "has_results": false,
      "last_update_posted_date": "2023-02-08",
      "last_synced_at": "2026-09-09T12:31:09.913Z",
      "location_count": 1,
      "location_summary": "Santa Monica, California",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05039476"
    }
  ]
}