{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SAPIEN+Transcatheter+Valve+Implantation", "query": { "intervention": "SAPIEN Transcatheter Valve Implantation" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 21, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SAPIEN+Transcatheter+Valve+Implantation&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-20T09:10:18.868Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04860765", "title": "COMPASSION S3 Post-Approval Study", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Complex Congenital Heart Defect", "Dysfunctional RVOT Conduit", "Pulmonary Valve Insufficiency", "Pulmonary Valve Degeneration", "Pulmonary Valve; Obstruction" ], "interventions": [ { "name": "SAPIEN 3 THV", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 150, "start_date": "2021-04-13", "completion_date": "2030-08", "has_results": false, "last_update_posted_date": "2026-02-03", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 19, "location_summary": "Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 15 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Oak Lawn", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04860765" }, { "nct_id": "NCT02687035", "title": "PARTNER II Trial: S3iCAP", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Stenosis" ], "interventions": [ { "name": "SAPIEN S3 valve", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 1822, "start_date": "2015-01", "completion_date": "2018-12", "has_results": true, "last_update_posted_date": "2021-04-08", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 55, "location_summary": "La Jolla, California • Los Angeles, California • Palo Alto, California + 46 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT02687035" }, { "nct_id": "NCT05172960", "title": "ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Stenosis, Severe" ], "interventions": [ { "name": "SAPIEN X4 THV", "type": "DEVICE" }, { "name": "SAPIEN X4S", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 1234, "start_date": "2022-06-20", "completion_date": "2037-01", "has_results": false, "last_update_posted_date": "2026-09-03", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 58, "location_summary": "La Jolla, California • Los Angeles, California • Newport Beach, California + 44 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05172960" }, { "nct_id": "NCT03193801", "title": "PARTNER 3 Trial - Mitral Valve in Valve", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Mitral Valve Insufficiency", "Mitral Valve Disease", "Mitral Valve Regurgitation", "Heart Failure" ], "interventions": [ { "name": "Edwards SAPIEN 3 transcatheter valve, Model 9600TFX", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 53, "start_date": "2018-02-01", "completion_date": "2031-08", "has_results": true, "last_update_posted_date": "2025-11-05", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 9, "location_summary": "Atlanta, Georgia • Chicago, Illinois • Evanston, Illinois + 6 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Evanston", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT03193801" }, { "nct_id": "NCT03222128", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 1074, "start_date": "2014-02-17", "completion_date": "2024-10-09", "has_results": true, "last_update_posted_date": "2025-01-03", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 51, "location_summary": "La Jolla, California • Los Angeles, California • Sacramento, California + 44 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03222128" }, { "nct_id": "NCT02987387", "title": "COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Pulmonary Valve Insufficiency", "Pulmonary Valve Stenosis", "Heart Defects, Congenital", "Congenital Abnormalities", "Cardiovascular Diseases", "Heart Diseases" ], "interventions": [ { "name": "SAPIEN XT THV", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 57, "start_date": "2017-07-17", "completion_date": "2025-09-30", "has_results": false, "last_update_posted_date": "2025-12-15", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 12, "location_summary": "Birmingham, Alabama • Aurora, Colorado • Washington D.C., District of Columbia + 9 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Oak Lawn", "state": "Illinois" }, { "city": "Iowa City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT02987387" }, { "nct_id": "NCT03222141", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation of the THV Prosthesis", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 583, "start_date": "2013-10", "completion_date": "2020-08", "has_results": true, "last_update_posted_date": "2021-05-12", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 39, "location_summary": "Los Angeles, California • Sacramento, California • Stanford, California + 34 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT03222141" }, { "nct_id": "NCT03015194", "title": "NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Mitral Valve Failure" ], "interventions": [ { "name": "Edwards SAPIEN 3 transcatheter heart valve", "type": "DEVICE" }, { "name": "ASHI INTECC Astato XS 20", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 32, "start_date": "2017-06-20", "completion_date": "2023-04-13", "has_results": true, "last_update_posted_date": "2023-08-15", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 6, "location_summary": "Washington D.C., District of Columbia • Atlanta, Georgia • Detroit, Michigan + 3 more", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Detroit", "state": "Michigan" }, { "city": "Falls Church", "state": "Virginia" }, { "city": "Roanoke", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT03015194" }, { "nct_id": "NCT02184442", "title": "The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Severe", "Symptomatic", "Calcific Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation with SAPIEN XT", "type": "DEVICE" }, { "name": "TAVR Implantation with SAPIEN", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 560, "start_date": "2011-03-09", "completion_date": "2017-05-30", "has_results": true, "last_update_posted_date": "2018-09-25", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 53, "location_summary": "Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 45 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02184442" }, { "nct_id": "NCT01314313", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation with SAPIEN XT", "type": "DEVICE" }, { "name": "SAVR Implantation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 2032, "start_date": "2011-03", "completion_date": "2024-01-17", "has_results": true, "last_update_posted_date": "2024-03-07", "last_synced_at": "2026-09-20T09:10:18.868Z", "location_count": 55, "location_summary": "Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 46 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01314313" } ] }