{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SMILE",
    "query": {
      "intervention": "SMILE"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 50,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SMILE&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-02T21:38:43.491Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04556175",
      "title": "Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Early Childhood Caries",
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Oral Health",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Healthy Lifestyle",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northern Arizona University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2021-03-29",
      "completion_date": "2022-03-01",
      "has_results": true,
      "last_update_posted_date": "2025-08-29",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 2,
      "location_summary": "Kykotsmovi, Arizona • Crow Agency, Montana",
      "locations": [
        {
          "city": "Kykotsmovi",
          "state": "Arizona"
        },
        {
          "city": "Crow Agency",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04556175"
    },
    {
      "nct_id": "NCT05564533",
      "title": "Heart-Smile Training Intensive Introduction Program",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "Heart-Smile Training Intensive Introduction Program (HST-IIP)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Cambridge Health Alliance",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 35,
      "start_date": "2023-02-09",
      "completion_date": "2024-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-07-11",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Somerville, Massachusetts",
      "locations": [
        {
          "city": "Somerville",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05564533"
    },
    {
      "nct_id": "NCT05294302",
      "title": "Testing eSCCIP: An eHealth Psychosocial Intervention for English and Spanish Speaking Parents of Children With Cancer",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pediatric Cancer"
      ],
      "interventions": [
        {
          "name": "eSCCIP/eSCCIP-SP",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Coping Space",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Nemours Children's Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 350,
      "start_date": "2023-04-14",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 3,
      "location_summary": "Los Angeles, California • Wilmington, Delaware • Houston, Texas",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05294302"
    },
    {
      "nct_id": "NCT07126756",
      "title": "LASIK iDesign vs SMILE",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myopia",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "STAR S4 IR Excimer Laser System",
          "type": "DEVICE"
        },
        {
          "name": "VisuMax 400 Surgical Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "59th Medical Wing",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 57,
      "start_date": "2024-06-10",
      "completion_date": "2026-01-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-17",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Lackland Air Force Base, Texas",
      "locations": [
        {
          "city": "Lackland Air Force Base",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07126756"
    },
    {
      "nct_id": "NCT04531618",
      "title": "Mother-infant Bonding During COVID-19",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Child Development",
        "Mother-Infant Interaction",
        "Relation, Parent-Child"
      ],
      "interventions": [
        {
          "name": "Emotional Exchange (EE)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Newborn Care (NC)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Hours",
        "maximum_age": "72 Hours",
        "sex": "ALL",
        "summary": "12 Hours to 72 Hours"
      },
      "enrollment_count": 132,
      "start_date": "2024-02-14",
      "completion_date": "2025-09-17",
      "has_results": false,
      "last_update_posted_date": "2026-06-09",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04531618"
    },
    {
      "nct_id": "NCT04975321",
      "title": "Clinical Trial NuSmile Crowns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Dental Caries, Multisurface Origin (Diagnosis)"
      ],
      "interventions": [
        {
          "name": "Nu Smile Zirconia crown",
          "type": "DEVICE"
        },
        {
          "name": "Nu Smile Pre Veneered crown",
          "type": "DEVICE"
        },
        {
          "name": "Composite strip crown",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "5 Years",
        "sex": "ALL",
        "summary": "Up to 5 Years"
      },
      "enrollment_count": 97,
      "start_date": "2015-06-06",
      "completion_date": "2019-07-19",
      "has_results": true,
      "last_update_posted_date": "2022-05-09",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04975321"
    },
    {
      "nct_id": "NCT06330207",
      "title": "An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Emergency Department Visit",
        "Odontalgia"
      ],
      "interventions": [
        {
          "name": "Clinical decision support tool",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2026-01-15",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-14",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06330207"
    },
    {
      "nct_id": "NCT04672239",
      "title": "A Proof-of-concept RCT of Version 3.0 of the Smoking Cessation Smartphone App \"Smiling Instead of Smoking\" (SiS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nondaily Smoking"
      ],
      "interventions": [
        {
          "name": "Smartphone app \"Smiling instead of Smoking\" (SiS) Version 3",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Smartphone app \"QuitGuide\" (QG)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Brochure \"Clearing the Air\" (CTA)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 229,
      "start_date": "2021-01-28",
      "completion_date": "2023-01-06",
      "has_results": true,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04672239"
    },
    {
      "nct_id": "NCT02576483",
      "title": "An Evaluation of LASIK, SMILE and PRK Surgery in Physicians",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Nearsightedness",
        "Farsightedness",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "Questionnaire (QoV questionnaire)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "62 Years",
        "sex": "ALL",
        "summary": "21 Years to 62 Years"
      },
      "enrollment_count": 700,
      "start_date": "2015-07",
      "completion_date": "2028-01",
      "has_results": false,
      "last_update_posted_date": "2024-10-23",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02576483"
    },
    {
      "nct_id": "NCT07287826",
      "title": "Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Oral Mucositis Due to Chemotherapy"
      ],
      "interventions": [
        {
          "name": "Dexamethasone Mouthwash",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2026-04-02",
      "completion_date": "2028-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-09-02T21:38:43.491Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07287826"
    }
  ]
}