{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SPD489+50+mg", "query": { "intervention": "SPD489 50 mg" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 13, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SPD489+50+mg&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-12T09:49:15.027Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01101022", "title": "Safety and Efficacy of SPD489 on Executive Function Behaviors in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "ADHD Specifically With Executive Function Impairment" ], "interventions": [ { "name": "SPD489", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 161, "start_date": "2010-05-19", "completion_date": "2010-11-29", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 39, "location_summary": "Little Rock, Arkansas • Rolling Hills Estates, California • San Diego, California + 34 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rolling Hills Estates", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Bradenton", "state": "Florida" }, { "city": "Fort Myers", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01101022" }, { "nct_id": "NCT01657019", "title": "Open Label Extension in Adults With Binge Eating Disorder (BED)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Binge Eating Disorder" ], "interventions": [ { "name": "Lisdexamfetamine dimesylate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 604, "start_date": "2012-08-21", "completion_date": "2014-10-21", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 84, "location_summary": "Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 77 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Corona", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01657019" }, { "nct_id": "NCT01436162", "title": "Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate )", "type": "DRUG" }, { "name": "Antidepressant + Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1105, "start_date": "2011-10-19", "completion_date": "2013-12-10", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 36, "location_summary": "Scottsdale, Arizona • Little Rock, Arkansas • Costa Mesa, California + 31 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Downey", "state": "California" }, { "city": "Escondido", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01436162" }, { "nct_id": "NCT01718483", "title": "SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Binge Eating Disorder" ], "interventions": [ { "name": "SPD489 (Lisdexamfetamine dimesylate)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 383, "start_date": "2012-11-26", "completion_date": "2013-09-25", "has_results": true, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 43, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Corona, California + 40 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Corona", "state": "California" }, { "city": "Encino", "state": "California" }, { "city": "Los Alamitos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01718483" }, { "nct_id": "NCT00922272", "title": "Efficacy, Safety, and Tolerability of SPD489 in Adults With Schizophrenia and Predominant Negative Symptoms", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia and Predominant Negative Symptoms" ], "interventions": [ { "name": "SPD489 (lisdexamfetamine dimesylate)", "type": "DRUG" }, { "name": "Placebo matching SPD489 (lisdexamfetamine dimesylate)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 92, "start_date": "2009-09-14", "completion_date": "2011-01-20", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 27, "location_summary": "Little Rock, Arkansas • Anaheim, California • Costa Mesa, California + 21 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Anaheim", "state": "California" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00922272" }, { "nct_id": "NCT01096680", "title": "Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep Loss", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Sleep Deprivation" ], "interventions": [ { "name": "SPD489 20 mg", "type": "DRUG" }, { "name": "SPD489 50 mg", "type": "DRUG" }, { "name": "SPD489 70 mg", "type": "DRUG" }, { "name": "Armodafinil", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "MALE", "summary": "18 Years to 40 Years · Male only" }, "enrollment_count": 135, "start_date": "2010-04-05", "completion_date": "2010-07-18", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01096680" }, { "nct_id": "NCT01291173", "title": "Forced-dose Titration of SPD489 in Adults With Binge Eating Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Binge Eating Disorder" ], "interventions": [ { "name": "lisdexamfetamine dimesylate (SPD489)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 271, "start_date": "2011-05-10", "completion_date": "2012-01-30", "has_results": true, "last_update_posted_date": "2021-06-10", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 31, "location_summary": "Little Rock, Arkansas • Beverly Hills, California • La Jolla, California + 28 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01291173" }, { "nct_id": "NCT01435759", "title": "SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 10 mg", "type": "DRUG" }, { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 30 mg", "type": "DRUG" }, { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 50 mg", "type": "DRUG" }, { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 70 mg", "type": "DRUG" }, { "name": "Antidepressant + Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1197, "start_date": "2011-05-31", "completion_date": "2014-01-17", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 60, "location_summary": "Little Rock, Arkansas • Anaheim, California • Chino, California + 54 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Chino", "state": "California" }, { "city": "Colton", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01435759" }, { "nct_id": "NCT00697515", "title": "Safety and Efficacy Workplace Environment Study of Lisdexamfetamine Dimesylate (LDX) in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "ADHD" ], "interventions": [ { "name": "LDX", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 142, "start_date": "2008-07-18", "completion_date": "2008-12-20", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 5, "location_summary": "Little Rock, Arkansas • Irvine, California • Overland Park, Kansas + 2 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Irvine", "state": "California" }, { "city": "Overland Park", "state": "Kansas" }, { "city": "Las Vegas", "state": "Nevada" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00697515" }, { "nct_id": "NCT02009163", "title": "Evaluate the Maintenance of Efficacy of SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Binge Eating Disorder" ], "interventions": [ { "name": "Lisdexamfetamine dimesylate", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 418, "start_date": "2014-01-27", "completion_date": "2015-04-08", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-12T09:49:15.027Z", "location_count": 39, "location_summary": "Fort Myers, Florida • Lauderhill, Florida • Leesburg, Florida + 35 more", "locations": [ { "city": "Fort Myers", "state": "Florida" }, { "city": "Lauderhill", "state": "Florida" }, { "city": "Leesburg", "state": "Florida" }, { "city": "Maitland", "state": "Florida" }, { "city": "North Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02009163" } ] }