{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SPD503", "query": { "intervention": "SPD503" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 8, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-05T23:04:38.750Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00367835", "title": "SPD503 (Guanfacine Hydrochloride) in ADHD Plus Oppositional Symptoms", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "ADHD" ], "interventions": [ { "name": "SPD503 (Guanfacine hydrochloride)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "6 Years to 12 Years" }, "enrollment_count": 217, "start_date": "2006-12-04", "completion_date": "2008-01-04", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 34, "location_summary": "Phoenix, Arizona • El Centro, California • Rolling Hills Estates, California + 29 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "El Centro", "state": "California" }, { "city": "Rolling Hills Estates", "state": "California" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00367835" }, { "nct_id": "NCT00734578", "title": "Efficacy and Safety of SPD503 in Combination With Psychostimulants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "ADHD" ], "interventions": [ { "name": "SPD503-AM", "type": "DRUG" }, { "name": "SPD503-PM", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 461, "start_date": "2008-09-02", "completion_date": "2009-12-10", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 61, "location_summary": "Dothan, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 53 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "El Centro", "state": "California" }, { "city": "Rolling Hills Estates", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00734578" }, { "nct_id": "NCT00919867", "title": "A Drug Interaction Study of SPD503 and Vyvanse Administered Alone and In Combination in Normal Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "SPD503", "type": "DRUG" }, { "name": "VYVANSE", "type": "DRUG" }, { "name": "SPD503 and VYVANSE", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 42, "start_date": "2009-06-24", "completion_date": "2009-07-30", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 1, "location_summary": "Hackensack, New Jersey", "locations": [ { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00919867" }, { "nct_id": "NCT04085172", "title": "A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Attention Deficit Hyperactivity Disorder" ], "interventions": [ { "name": "Guanfacine hydrochloride (TAK-503)", "type": "DRUG" }, { "name": "Atomoxetine hydrochloride", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 396, "start_date": "2019-09-18", "completion_date": "2025-09-02", "has_results": true, "last_update_posted_date": "2026-04-13", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 20, "location_summary": "Dothan, Alabama • Anaheim, California • Imperial, California + 17 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Anaheim", "state": "California" }, { "city": "Imperial", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04085172" }, { "nct_id": "NCT01156051", "title": "Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Attention-Deficit/Hyperactivity Disorder", "Attention Deficit Disorder", "Insomnia", "Sleep Disorders" ], "interventions": [ { "name": "Guanfacine extended-release tablets", "type": "DRUG" }, { "name": "Placebo comparator", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Children's Specialized Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "6 Years to 12 Years" }, "enrollment_count": 29, "start_date": "2010-06", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2014-08-11", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 2, "location_summary": "Hamilton, New Jersey • Toms River, New Jersey", "locations": [ { "city": "Hamilton", "state": "New Jersey" }, { "city": "Toms River", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01156051" }, { "nct_id": "NCT00901576", "title": "A Drug Interaction Study of SPD503 and Concerta Administered Alone and In Combination in Normal Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "SPD503", "type": "DRUG" }, { "name": "Concerta", "type": "DRUG" }, { "name": "SPD503 + Concerta", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 38, "start_date": "2009-05-18", "completion_date": "2009-07-06", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 1, "location_summary": "Hackensack, New Jersey", "locations": [ { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00901576" }, { "nct_id": "NCT00997984", "title": "Tolerability and Efficacy of AM and PM Once Daily Dosing With Extended-release Guanfacine Hydrochloride in Children 6-12 With Attention-Deficit/Hyperactivity Disorder (ADHD) (The ADHD Tempo Study)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Attention-Deficit/Hyperactivity Disorder" ], "interventions": [ { "name": "extended-release guanfacine hydrochloride (SPD503)", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "extended-release guanfacine hydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "6 Years to 12 Years" }, "enrollment_count": 340, "start_date": "2009-11-17", "completion_date": "2010-10-09", "has_results": true, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 42, "location_summary": "Little Rock, Arkansas • El Centro, California • Rolling Hills Estates, California + 38 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "El Centro", "state": "California" }, { "city": "Rolling Hills Estates", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Wildomar", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00997984" }, { "nct_id": "NCT01470469", "title": "SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Generalized Anxiety Disorder (GAD)", "Anxiety, Separation", "Phobia, Social" ], "interventions": [ { "name": "SPD503 (extended-release Guanfacine hydrochloride)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 83, "start_date": "2012-01-04", "completion_date": "2013-07-15", "has_results": true, "last_update_posted_date": "2021-06-10", "last_synced_at": "2026-09-05T23:04:38.750Z", "location_count": 33, "location_summary": "Birmingham, Alabama • Carson, California • Imperial, California + 29 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Carson", "state": "California" }, { "city": "Imperial", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01470469" } ] }