{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SSRI%2FSNRI&page=2", "query": { "intervention": "SSRI/SNRI", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=SSRI%2FSNRI&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-18T03:35:51.399Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01856127", "title": "Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Sexual Dysfunction", "Major Depressive Disorder" ], "interventions": [ { "name": "Vilazodone", "type": "DRUG" }, { "name": "Sertraline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Thomas Jefferson University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 4, "start_date": "2013-01", "completion_date": "2016-06", "has_results": false, "last_update_posted_date": "2016-08-25", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 3, "location_summary": "Philadelphia, Pennsylvania • Charlottesville, Virginia", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Charlottesville", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01856127" }, { "nct_id": "NCT06559306", "title": "Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Seltorexant", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 752, "start_date": "2024-07-25", "completion_date": "2027-04-15", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 84, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Tucson, Arizona + 65 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Bryant", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06559306" }, { "nct_id": "NCT02015546", "title": "Switching From Generic Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) to Three Different Dose Initiation Strategies With Vilazodone", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder (MDD)" ], "interventions": [ { "name": "Vilazodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 70, "start_date": "2012-12", "completion_date": "2013-12", "has_results": true, "last_update_posted_date": "2015-04-16", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02015546" }, { "nct_id": "NCT01157078", "title": "A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "Depression" ], "interventions": [ { "name": "TC-5214", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 319, "start_date": "2010-06", "completion_date": "2011-11", "has_results": true, "last_update_posted_date": "2014-04-11", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 37, "location_summary": "Tuscaloosa, Alabama • Tucson, Arizona • Little Rock, Arkansas + 34 more", "locations": [ { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Chino", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01157078" }, { "nct_id": "NCT01204918", "title": "Efficacy and Tolerability of Riluzole in Treatment Resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression" ], "interventions": [ { "name": "Riluzole", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 104, "start_date": "2011-06", "completion_date": "2015-08", "has_results": true, "last_update_posted_date": "2020-03-06", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 3, "location_summary": "New Haven, Connecticut • Boston, Massachusetts • Houston, Texas", "locations": [ { "city": "New Haven", "state": "Connecticut" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01204918" }, { "nct_id": "NCT06049797", "title": "A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hot Flashes" ], "interventions": [ { "name": "Fezolinetant", "type": "DRUG" }, { "name": "Paroxetine", "type": "DRUG" }, { "name": "Citalopram", "type": "DRUG" }, { "name": "Escitalopram", "type": "DRUG" }, { "name": "Desvenlafaxine", "type": "DRUG" }, { "name": "Venlafaxine", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Clonidine", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Oxybutynin", "type": "DRUG" }, { "name": "Any other SSRI/SNRI not already specified", "type": "DRUG" }, { "name": "Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Astellas Pharma Global Development, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "75 Years", "sex": "FEMALE", "summary": "40 Years to 75 Years · Female only" }, "enrollment_count": 999, "start_date": "2023-11-15", "completion_date": "2026-05-07", "has_results": false, "last_update_posted_date": "2026-06-05", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 48, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Lomita, California + 39 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Lomita", "state": "California" }, { "city": "Pomona", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06049797" }, { "nct_id": "NCT00591565", "title": "An 8 Week Open-Label Study to Evaluate the Efficacy and Safety of Acamprosate Calcium (Campral) as Augmentation Therapy in Patients With Anxiety Symptoms Who Are Only Partial Responders to SSRI or SNRI Antidepressants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Anxiety" ], "interventions": [ { "name": "Acamprosate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "State University of New York - Upstate Medical University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 13, "start_date": "2006-06", "completion_date": "2009-12", "has_results": true, "last_update_posted_date": "2014-12-18", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 1, "location_summary": "Syracuse, New York", "locations": [ { "city": "Syracuse", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00591565" }, { "nct_id": "NCT06633016", "title": "Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "ABX-002", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Autobahn Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 230, "start_date": "2024-09-20", "completion_date": "2026-06", "has_results": false, "last_update_posted_date": "2026-01-20", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 50, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 44 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06633016" }, { "nct_id": "NCT01152554", "title": "A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "MDD", "Depression" ], "interventions": [ { "name": "TC-5214", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 813, "start_date": "2010-06", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2014-04-11", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 93, "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Tucson, Arizona + 90 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Arcadia", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01152554" }, { "nct_id": "NCT04019704", "title": "A Trial of AXS-05 in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depression", "Major Depressive Disorder" ], "interventions": [ { "name": "AXS-05", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Axsome Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 327, "start_date": "2019-06-20", "completion_date": "2019-12-05", "has_results": true, "last_update_posted_date": "2022-10-12", "last_synced_at": "2026-09-18T03:35:51.399Z", "location_count": 43, "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Bellflower, California + 39 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04019704" } ] }