{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sacubitril%2Fvalsartan&page=2", "query": { "intervention": "Sacubitril/valsartan", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 62, "total_pages": 7, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sacubitril%2Fvalsartan&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sacubitril%2Fvalsartan&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-02T12:41:45.788Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01281306", "title": "An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Systolic Hypertension" ], "interventions": [ { "name": "LCZ696", "type": "DRUG" }, { "name": "Valsartan", "type": "DRUG" }, { "name": "AHU377", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 910, "start_date": "2011-01", "completion_date": "2011-12", "has_results": true, "last_update_posted_date": "2016-01-29", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 19, "location_summary": "Clearwater, Florida • Chicago, Illinois • Metairie, Louisiana + 12 more", "locations": [ { "city": "Clearwater", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Metairie", "state": "Louisiana" }, { "city": "Belzoni", "state": "Mississippi" } ], "official_url": "https://clinicaltrials.gov/study/NCT01281306" }, { "nct_id": "NCT00887588", "title": "LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Heart Failure" ], "interventions": [ { "name": "LCZ696", "type": "DRUG" }, { "name": "Valsartan", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 307, "start_date": "2009-11", "completion_date": "2011-12", "has_results": true, "last_update_posted_date": "2015-08-25", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 11, "location_summary": "Little Rock, Arkansas • Chicago, Illinois • Detroit, Michigan + 8 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Detroit", "state": "Michigan" }, { "city": "Grand Island", "state": "Nebraska" }, { "city": "Lincoln", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT00887588" }, { "nct_id": "NCT01681576", "title": "Assessment of LCZ696 and Valsartan in Asian Patients With Salt-sensitive Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Salt-sensitive Hypertension" ], "interventions": [ { "name": "Valsartan", "type": "DRUG" }, { "name": "LCZ696", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 72, "start_date": "2012-08", "completion_date": "2013-10", "has_results": true, "last_update_posted_date": "2015-11-10", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 3, "location_summary": "Anaheim, California • Cypress, California • Glendale, California", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Cypress", "state": "California" }, { "city": "Glendale", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01681576" }, { "nct_id": "NCT01035255", "title": "This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart Failure With Reduced Ejection Fraction" ], "interventions": [ { "name": "LCZ696 200 mg BID", "type": "DRUG" }, { "name": "Enalapril 10 mg BID", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 8442, "start_date": "2009-12", "completion_date": "2014-05", "has_results": true, "last_update_posted_date": "2016-08-15", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 155, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 129 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT01035255" }, { "nct_id": "NCT04743063", "title": "Prospective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and Frailty", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Heart Failure, Systolic", "Frailty" ], "interventions": [ { "name": "sacubitril/valsartan", "type": "DRUG" }, { "name": "Angiotensin II Receptor Blockers", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 40000, "start_date": "2021-01-14", "completion_date": "2022-12-31", "has_results": false, "last_update_posted_date": "2021-02-15", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04743063" }, { "nct_id": "NCT05096143", "title": "A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Heart Failure" ], "interventions": [ { "name": "Sacubitril/valsartan", "type": "DRUG" }, { "name": "ACEi/ARB", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 42269, "start_date": "2020-06-03", "completion_date": "2020-10-19", "has_results": false, "last_update_posted_date": "2021-12-21", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 1, "location_summary": "East Hanover, New Jersey", "locations": [ { "city": "East Hanover", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05096143" }, { "nct_id": "NCT03938389", "title": "The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "PreDiabetes", "Impaired Glucose Tolerance", "Obesity", "Blood Pressure" ], "interventions": [ { "name": "Sacubitril-Valsartan Tab 97-103 MG", "type": "DRUG" }, { "name": "Valsartan 160mg", "type": "DRUG" }, { "name": "Placebo Oral Tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 90, "start_date": "2020-02-25", "completion_date": "2026-06", "has_results": false, "last_update_posted_date": "2025-08-11", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03938389" }, { "nct_id": "NCT02754518", "title": "Demonstration of Reverse Remodeling Effects of Entresto. Using Echocardiography Endocardial Surface Analysis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Failure" ], "interventions": [ { "name": "Entresto", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2016-04", "completion_date": "2019-04", "has_results": true, "last_update_posted_date": "2021-01-29", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02754518" }, { "nct_id": "NCT02389933", "title": "Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)", "overall_status": "NO_LONGER_AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Heart Failure With Reduced Ejection Fraction (HF-rEF)" ], "interventions": [ { "name": "LCZ696", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2021-02-15", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 1, "location_summary": "Vero Beach, Florida", "locations": [ { "city": "Vero Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02389933" }, { "nct_id": "NCT02554890", "title": "Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Acute Heart Failure" ], "interventions": [ { "name": "sacubitril/valsartan (LCZ696)", "type": "DRUG" }, { "name": "Enalapril", "type": "DRUG" }, { "name": "sacubitril/valsartan (LCZ696) matching placebo", "type": "DRUG" }, { "name": "enalapril matching placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 887, "start_date": "2016-04-29", "completion_date": "2018-07-24", "has_results": true, "last_update_posted_date": "2021-01-05", "last_synced_at": "2026-10-02T12:41:45.788Z", "location_count": 123, "location_summary": "Birmingham, Alabama • Fort Smith, Arkansas • Little Rock, Arkansas + 105 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Fort Smith", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bakersfield", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02554890" } ] }