{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Safe+and+Sound+Protocol",
    "query": {
      "intervention": "Safe and Sound Protocol"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T17:23:55.591Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07219056",
      "title": "Safe & Sound Protocol in Adults With Trauma and SUD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use Disorders",
        "Posttraumatic Stress Symptom",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Safe and Sound Protocol",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Caron Treatment Centers",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 100,
      "start_date": "2025-12-15",
      "completion_date": "2027-03-15",
      "has_results": false,
      "last_update_posted_date": "2026-08-03",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Wernersville, Pennsylvania",
      "locations": [
        {
          "city": "Wernersville",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07219056"
    },
    {
      "nct_id": "NCT06701578",
      "title": "The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety",
        "Depression"
      ],
      "interventions": [
        {
          "name": "Safe and Sound Protocol",
          "type": "OTHER"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "HealthPartners Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2026-06",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2025-07-28",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Saint Paul, Minnesota",
      "locations": [
        {
          "city": "Saint Paul",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06701578"
    },
    {
      "nct_id": "NCT06925867",
      "title": "A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "PTSD - Post Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Frequency Filtered Music",
          "type": "OTHER"
        },
        {
          "name": "Unfiltered Music",
          "type": "OTHER"
        },
        {
          "name": "Cognitive Processing Therapy for PTSD",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2025-01-10",
      "completion_date": "2028-02-14",
      "has_results": false,
      "last_update_posted_date": "2026-02-03",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Dayton, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Dayton",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06925867"
    },
    {
      "nct_id": "NCT05212129",
      "title": "Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Functional Gastrointestinal Disorders",
        "Hypermobile Ehlers-Danlos Syndrome",
        "Postural Orthostatic Tachycardia Syndrome",
        "Autonomic Nervous System Disease",
        "Autonomic Nervous System Imbalance"
      ],
      "interventions": [
        {
          "name": "Percutaneous vagal nerve stimulation (pVNS) device",
          "type": "DEVICE"
        },
        {
          "name": "Acoustic vagal nerve stimulation (aVNS) treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "10 Years to 18 Years"
      },
      "enrollment_count": 90,
      "start_date": "2021-04-05",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05212129"
    },
    {
      "nct_id": "NCT05249270",
      "title": "Online Parent-Report Evaluation of the Effects of Processed Music",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sensory Disorders",
        "Sensory Processing Disorder",
        "Autism Spectrum Disorder",
        "Eating Disorders",
        "Gastro-Intestinal Disorder",
        "Swallowing Disorder",
        "Anxiety"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 132,
      "start_date": "2020-03-22",
      "completion_date": "2022-06-28",
      "has_results": false,
      "last_update_posted_date": "2024-08-20",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Woodinville, Washington",
      "locations": [
        {
          "city": "Woodinville",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05249270"
    },
    {
      "nct_id": "NCT04999852",
      "title": "The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post Traumatic Stress Disorder",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Safe and Sound Protocol",
          "type": "DEVICE"
        },
        {
          "name": "Psychotherapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2021-07-12",
      "completion_date": "2023-12-07",
      "has_results": true,
      "last_update_posted_date": "2025-09-05",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Bloomington, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04999852"
    },
    {
      "nct_id": "NCT03083977",
      "title": "Examining the Effects of Processed Music on Chronic Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain"
      ],
      "interventions": [
        {
          "name": "Safe and Sound Protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 8,
      "start_date": "2017-06-22",
      "completion_date": "2019-08-28",
      "has_results": false,
      "last_update_posted_date": "2022-03-07",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Bloomington, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03083977"
    },
    {
      "nct_id": "NCT06915428",
      "title": "Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Birth Complication",
        "Preterm Birth",
        "Preterm Birth Recurrence",
        "Preeclampsia",
        "Preeclampsia (PE)",
        "Hypertensive Disorders of Pregnancy",
        "Support Program",
        "Stress",
        "Resilience, Psychological",
        "Empowerment, Patient",
        "Emotional Stress",
        "Pregnancy",
        "Pregnancy Complications",
        "Pregnancy Induced Hypertension",
        "Neonates and Preterm Infants",
        "Cervical Insufficiency",
        "Social Determinants of Health (SDOH)",
        "Cervical Shortening",
        "Disparities in Pregnancy Complications",
        "Disparities",
        "Prenatal Care",
        "Care Coordination"
      ],
      "interventions": [
        {
          "name": "Care coordination",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Electronic massage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "support gift #1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #3",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #4",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Additional PTBCARE+ support",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stress reduction toolkit - Visit 1 (V1)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PTBCARE+ mobile application (app) and website",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Sleep, meditation, and Wellness app",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Emergency low blood sugar kit",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Low dose aspirin (LDA)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Visit #2 Stress Reduction Toolkit",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1228,
      "start_date": "2026-08-01",
      "completion_date": "2029-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-29",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06915428"
    },
    {
      "nct_id": "NCT03101826",
      "title": "Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prader-Willi Syndrome"
      ],
      "interventions": [
        {
          "name": "Listening Project Protocol",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "13 Years to 25 Years"
      },
      "enrollment_count": 5,
      "start_date": "2017-11-01",
      "completion_date": "2023-03-08",
      "has_results": false,
      "last_update_posted_date": "2023-04-03",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Brewster, Massachusetts",
      "locations": [
        {
          "city": "Brewster",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03101826"
    },
    {
      "nct_id": "NCT03871751",
      "title": "Home-based SSP on Individuals With PWS",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prader-Willi Syndrome"
      ],
      "interventions": [
        {
          "name": "Safe and Sound Protocol",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "3 Years to 17 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-04-08",
      "completion_date": "2019-12-16",
      "has_results": false,
      "last_update_posted_date": "2022-03-07",
      "last_synced_at": "2026-09-03T17:23:55.591Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03871751"
    }
  ]
}