{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Samidorphan", "query": { "intervention": "Samidorphan" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 30, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Samidorphan&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-03T11:27:20.055Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02218008", "title": "A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - FORWARD-5 Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "ALKS 5461", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 407, "start_date": "2014-07", "completion_date": "2016-10", "has_results": true, "last_update_posted_date": "2019-08-14", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 32, "location_summary": "Birmingham, Alabama • Colton, California • Garden Grove, California + 29 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Colton", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Oakland", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02218008" }, { "nct_id": "NCT02161718", "title": "A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia", "Alcohol Use Disorder" ], "interventions": [ { "name": "Samidorphan + olanzapine (ALKS 3831)", "type": "DRUG" }, { "name": "Placebo + olanzapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 300, "start_date": "2014-05", "completion_date": "2017-02-01", "has_results": true, "last_update_posted_date": "2021-10-08", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 58, "location_summary": "Little Rock, Arkansas • Springdale, Arkansas • Anaheim, California + 50 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Springdale", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02161718" }, { "nct_id": "NCT02218021", "title": "A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "Samidorphan", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 59, "start_date": "2014-08", "completion_date": "2014-11", "has_results": false, "last_update_posted_date": "2014-12-02", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02218021" }, { "nct_id": "NCT01903837", "title": "A Study of ALKS 3831 in Adults With Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Samidorphan (Low Dose)", "type": "DRUG" }, { "name": "Samidorphan (Medium Dose)", "type": "DRUG" }, { "name": "Samidorphan (High Dose)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Olanzapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 347, "start_date": "2013-06", "completion_date": "2015-03", "has_results": true, "last_update_posted_date": "2021-10-06", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 50, "location_summary": "Little Rock, Arkansas • Anaheim, California • Costa Mesa, California + 43 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Escondido", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01903837" }, { "nct_id": "NCT03187769", "title": "Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia", "Schizophreniform Disorders", "Bipolar I Disorder" ], "interventions": [ { "name": "ALKS 3831", "type": "DRUG" }, { "name": "Olanzapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "16 Years to 40 Years" }, "enrollment_count": 426, "start_date": "2017-06-08", "completion_date": "2022-01-03", "has_results": true, "last_update_posted_date": "2023-01-19", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 25, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Garden Grove, California + 19 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Garden Grove", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Stanford", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03187769" }, { "nct_id": "NCT02479308", "title": "A Study to Evaluate the Effect of ALKS 5461 on QT Intervals in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Moxifloxacin", "type": "DRUG" }, { "name": "ALKS 5461", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 129, "start_date": "2015-06", "completion_date": "2015-10", "has_results": false, "last_update_posted_date": "2015-11-23", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02479308" }, { "nct_id": "NCT04987658", "title": "Phase 1 Study of OLZ/SAM in Pediatric Subjects With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Bipolar I Disorder" ], "interventions": [ { "name": "OLZ/SAM", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "10 Years to 12 Years" }, "enrollment_count": 7, "start_date": "2021-07-22", "completion_date": "2023-08-11", "has_results": false, "last_update_posted_date": "2023-11-22", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 2, "location_summary": "Decatur, Georgia • Cincinnati, Ohio", "locations": [ { "city": "Decatur", "state": "Georgia" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04987658" }, { "nct_id": "NCT05547100", "title": "Study of the Breast Milk Pharmacokinetics of Olanzapine and Samidorphan", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Focus of Study is on Healthy Lactating Women" ], "interventions": [ { "name": "LYBALVI", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 12, "start_date": "2022-09-14", "completion_date": "2022-11-19", "has_results": false, "last_update_posted_date": "2023-02-10", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT05547100" }, { "nct_id": "NCT07744113", "title": "An Expanded Access Program (EAP) for OLZ/SAM in Pediatric Participants With Schizophrenia or Bipolar I Disorder (ALKS 3831-315)", "overall_status": "AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Bipolar 1 Disorder", "Schizophrenia Disorder" ], "interventions": [ { "name": "OLZ/SAM", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2026-08-04", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 1, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07744113" }, { "nct_id": "NCT02634346", "title": "A Study of ALKS 3831 in Adults With Acute Exacerbation of Schizophrenia (the ENLIGHTEN-1 Study)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "ALK3831", "type": "DRUG" }, { "name": "Olanzapine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alkermes, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 403, "start_date": "2015-12", "completion_date": "2017-06-07", "has_results": true, "last_update_posted_date": "2018-06-27", "last_synced_at": "2026-09-03T11:27:20.055Z", "location_count": 16, "location_summary": "Little Rock, Arkansas • Springdale, Arkansas • Culver City, California + 13 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Springdale", "state": "Arkansas" }, { "city": "Culver City", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Lemon Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02634346" } ] }