{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Selective+Serotonin+Reuptake+Inhibitor+%28SSRI%29%2FSerotonin-Norepinephrine+Reuptake+Inhibitor+%28SNRI%29&page=2", "query": { "intervention": "Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 28, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Selective+Serotonin+Reuptake+Inhibitor+%28SSRI%29%2FSerotonin-Norepinephrine+Reuptake+Inhibitor+%28SNRI%29&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Selective+Serotonin+Reuptake+Inhibitor+%28SSRI%29%2FSerotonin-Norepinephrine+Reuptake+Inhibitor+%28SNRI%29&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-12T03:49:54.541Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01152554", "title": "A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "MDD", "Depression" ], "interventions": [ { "name": "TC-5214", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 813, "start_date": "2010-06", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2014-04-11", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 93, "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Tucson, Arizona + 90 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Arcadia", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01152554" }, { "nct_id": "NCT04039022", "title": "Open-Label Safety Study of AXS-05 in Subjects With Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "Treatment Resistant Depression", "Depression" ], "interventions": [ { "name": "AXS-05 (dextromethorphan and bupropion) oral tablets", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Axsome Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 876, "start_date": "2019-07-08", "completion_date": "2020-10-23", "has_results": true, "last_update_posted_date": "2022-10-12", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 51, "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Bellflower, California + 46 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Culver City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04039022" }, { "nct_id": "NCT01040208", "title": "12 Week Safety Trial of Flibanserin in Depressed Women Taking an SSRI or SNRI With Decreased Sexual Desire and Distress", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Sexual Dysfunctions, Psychological", "Depression" ], "interventions": [ { "name": "flibanserin 50 mg to 100 mg qhs", "type": "DRUG" }, { "name": "flibanserin 100 mg qhs", "type": "DRUG" }, { "name": "placebo 2 tablets qhs", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sprout Pharmaceuticals, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 111, "start_date": "2010-01", "completion_date": "2011-01", "has_results": true, "last_update_posted_date": "2016-08-24", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 42, "location_summary": "Costa Mesa, California • Fresno, California • National City, California + 36 more", "locations": [ { "city": "Costa Mesa", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "National City", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "Sherman Oaks", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01040208" }, { "nct_id": "NCT05518149", "title": "A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Aticaprant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 871, "start_date": "2022-09-22", "completion_date": "2025-05-08", "has_results": true, "last_update_posted_date": "2026-10-06", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 87, "location_summary": "Birmingham, Alabama • Tucson, Arizona • Anaheim, California + 70 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Culver City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05518149" }, { "nct_id": "NCT00395213", "title": "Antidepressant Safety in Kids Study", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Anxiety Disorders", "Depressive Disorders", "Eating Disorders", "Obsessive Compulsive Disorder" ], "interventions": [ { "name": "Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) medications", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "7 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "7 Years to 17 Years" }, "enrollment_count": 569, "start_date": "2007-05", "completion_date": "2009-07", "has_results": false, "last_update_posted_date": "2015-04-17", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00395213" }, { "nct_id": "NCT01153347", "title": "A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "Depression" ], "interventions": [ { "name": "TC-5214", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 2409, "start_date": "2010-06", "completion_date": "2012-01", "has_results": true, "last_update_posted_date": "2014-04-11", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 79, "location_summary": "Birmingham, Alabama • Tucson, Arizona • Conway, Arkansas + 76 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Conway", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Arcadia", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01153347" }, { "nct_id": "NCT06049797", "title": "A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hot Flashes" ], "interventions": [ { "name": "Fezolinetant", "type": "DRUG" }, { "name": "Paroxetine", "type": "DRUG" }, { "name": "Citalopram", "type": "DRUG" }, { "name": "Escitalopram", "type": "DRUG" }, { "name": "Desvenlafaxine", "type": "DRUG" }, { "name": "Venlafaxine", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Clonidine", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Oxybutynin", "type": "DRUG" }, { "name": "Any other SSRI/SNRI not already specified", "type": "DRUG" }, { "name": "Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Astellas Pharma Global Development, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "75 Years", "sex": "FEMALE", "summary": "40 Years to 75 Years · Female only" }, "enrollment_count": 999, "start_date": "2023-11-15", "completion_date": "2026-05-07", "has_results": false, "last_update_posted_date": "2026-06-05", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 48, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Lomita, California + 39 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Lomita", "state": "California" }, { "city": "Pomona", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06049797" }, { "nct_id": "NCT01318434", "title": "A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "EB-1010 25mg BID", "type": "DRUG" }, { "name": "SSRI Active", "type": "DRUG" }, { "name": "EB-1010 50mg BID", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Euthymics BioScience, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 342, "start_date": "2011-02", "completion_date": "2013-02", "has_results": false, "last_update_posted_date": "2015-12-04", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 43, "location_summary": "Arcadia, California • Beverly Hills, California • National City, California + 39 more", "locations": [ { "city": "Arcadia", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "National City", "state": "California" }, { "city": "Santa Ana", "state": "California" }, { "city": "Upland", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01318434" }, { "nct_id": "NCT01001559", "title": "Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "L-methylfolate", "type": "DRUG" }, { "name": "Selective serotonin reuptake inhibitor (SSRI)", "type": "DRUG" }, { "name": "Serotonin and norepinephrine reuptake inhibitor (SNRI)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pamlab, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 242, "start_date": "2009-08", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2013-12-19", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01001559" }, { "nct_id": "NCT06559306", "title": "Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Seltorexant", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 752, "start_date": "2024-07-25", "completion_date": "2027-12-15", "has_results": false, "last_update_posted_date": "2026-09-25", "last_synced_at": "2026-10-12T03:49:54.541Z", "location_count": 84, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Tucson, Arizona + 65 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Bryant", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06559306" } ] }