{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sham+injection+%2B+laser", "query": { "intervention": "Sham injection + laser" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 14, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sham+injection+%2B+laser&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-17T03:23:23.502Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01788475", "title": "Safety and Effectiveness of Ozurdex Steroid Implants for DME After Vitrectomy Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "Dexamethasone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lahey Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 3, "start_date": "2013-02-22", "completion_date": "2014-11-12", "has_results": true, "last_update_posted_date": "2020-03-12", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 1, "location_summary": "Peabody, Massachusetts", "locations": [ { "city": "Peabody", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01788475" }, { "nct_id": "NCT02634333", "title": "Anti-VEGF Treatment for Prevention of PDR/DME", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetic Retinopathy", "Diabetic Macular Edema" ], "interventions": [ { "name": "Prompt Sham", "type": "PROCEDURE" }, { "name": "Prompt aflibercept", "type": "DRUG" }, { "name": "Deferred laser", "type": "PROCEDURE" }, { "name": "Deferred aflibercept", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "Jaeb Center for Health Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 399, "start_date": "2016-01", "completion_date": "2022-05-11", "has_results": true, "last_update_posted_date": "2023-06-18", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 81, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Huntington Beach, California + 68 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Oakland", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02634333" }, { "nct_id": "NCT04919499", "title": "A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diabetic Retinopathy" ], "interventions": [ { "name": "BI 765128", "type": "DRUG" }, { "name": "Sham comparator", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2021-07-30", "completion_date": "2023-08-07", "has_results": true, "last_update_posted_date": "2024-11-21", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 11, "location_summary": "Bakersfield, California • Sacramento, California • Walnut Creek, California + 7 more", "locations": [ { "city": "Bakersfield", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Hagerstown", "state": "Maryland" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04919499" }, { "nct_id": "NCT02348918", "title": "Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "Luminate 1.0mg", "type": "DRUG" }, { "name": "Luminate 2.0mg", "type": "DRUG" }, { "name": "Luminate 3.0mg", "type": "DRUG" }, { "name": "Avastin", "type": "DRUG" }, { "name": "Luminate 0.5mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allegro Ophthalmics, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 218, "start_date": "2014-10-13", "completion_date": "2017-06-13", "has_results": true, "last_update_posted_date": "2018-12-07", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 17, "location_summary": "Phoenix, Arizona • Beverly Hills, California • Mountain View, California + 14 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Mountain View", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Santa Ana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02348918" }, { "nct_id": "NCT00445003", "title": "Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Proliferative Diabetic Retinopathy", "Diabetic Macular Edema" ], "interventions": [ { "name": "Ranibizumab", "type": "DRUG" }, { "name": "Triamcinolone Acetonide", "type": "DRUG" }, { "name": "Sham injection", "type": "BEHAVIORAL" }, { "name": "Focal/grid laser", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "BEHAVIORAL", "PROCEDURE" ], "sponsor": "Jaeb Center for Health Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 333, "start_date": "2007-03", "completion_date": "2010-07", "has_results": true, "last_update_posted_date": "2016-08-26", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 56, "location_summary": "Artesia, California • Beverly Hills, California • Irvine, California + 46 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Palm Springs", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00445003" }, { "nct_id": "NCT01020747", "title": "Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Recurrent Respiratory Papillomatosis" ], "interventions": [ { "name": "Avastin® (bevacizumab)", "type": "DRUG" }, { "name": "Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 20, "start_date": "2009-11", "completion_date": "2011-03", "has_results": true, "last_update_posted_date": "2012-12-20", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01020747" }, { "nct_id": "NCT04424290", "title": "HORNBILL: A Study to Test Different Doses of BI 764524 in Patients Who Have Had Laser Treatment for a Type of Diabetic Eye Disease Called Diabetic Retinopathy With Diabetic Macular Ischemia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diabetic Retinopathy" ], "interventions": [ { "name": "BI 764524", "type": "DRUG" }, { "name": "Sham control of BI 764524", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 45, "start_date": "2020-06-12", "completion_date": "2023-04-28", "has_results": true, "last_update_posted_date": "2024-05-22", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 13, "location_summary": "Dothan, Alabama • Beverly Hills, California • Palo Alto, California + 10 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Orlando", "state": "Florida" }, { "city": "Carmel", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04424290" }, { "nct_id": "NCT00605280", "title": "A Multi-Center Trial To Evaluate The Safety And Efficacy Of Pegaptanib Sodium(Macugen) Injected Into The Eye Every 6 Weeks For Up To 2 Years For Macular Swelling Associated With Diabetes, With An Open-Label Macugen Year Extension.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Macular Edema Associated With Diabetes Mellitus" ], "interventions": [ { "name": "Standard of Care", "type": "DRUG" }, { "name": "Macugen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 317, "start_date": "2005-09", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2018-11-16", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 28, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Los Angeles, California + 24 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Oakland", "state": "California" }, { "city": "Santa Ana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00605280" }, { "nct_id": "NCT00344968", "title": "Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "Fluocinolone Acetonide", "type": "DRUG" }, { "name": "Standard of care laser photocoagulation", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Alimera Sciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 956, "start_date": "2007-09", "completion_date": "2010-12", "has_results": true, "last_update_posted_date": "2014-05-07", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00344968" }, { "nct_id": "NCT02229175", "title": "Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "bevacizumab", "type": "DRUG" }, { "name": "PASCAL Endpoint Management (EpM) laser treatment", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2021-01-01", "completion_date": "2027-01-01", "has_results": false, "last_update_posted_date": "2020-07-31", "last_synced_at": "2026-09-17T03:23:23.502Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02229175" } ] }