{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sodium+Fluoride+dentifrice",
    "query": {
      "intervention": "Sodium Fluoride dentifrice"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 139,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sodium+Fluoride+dentifrice&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T04:11:23.975Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00763048",
      "title": "Collection of Gingival Crevicular Fluid From Periodontitis Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Gingival Diseases"
      ],
      "interventions": [
        {
          "name": "Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Fluoride, triclosan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "26 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "26 Years to 68 Years"
      },
      "enrollment_count": 39,
      "start_date": "2008-03",
      "completion_date": "2008-04",
      "has_results": true,
      "last_update_posted_date": "2011-06-14",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00763048"
    },
    {
      "nct_id": "NCT01657877",
      "title": "Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Caries"
      ],
      "interventions": [
        {
          "name": "Calcium sodium phosphosilicate",
          "type": "DRUG"
        },
        {
          "name": "Sodium monoflurophosphate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 100,
      "start_date": "2012-05",
      "completion_date": "2013-06",
      "has_results": true,
      "last_update_posted_date": "2014-10-01",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01657877"
    },
    {
      "nct_id": "NCT01040169",
      "title": "Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypersensitivity"
      ],
      "interventions": [
        {
          "name": "Arginine/Calcium Carbonate",
          "type": "DEVICE"
        },
        {
          "name": "Mint Prophy paste - Fluoride free",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 79,
      "start_date": "2008-05",
      "completion_date": "2008-08",
      "has_results": true,
      "last_update_posted_date": "2013-12-10",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01040169"
    },
    {
      "nct_id": "NCT07398846",
      "title": "Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Plaque"
      ],
      "interventions": [
        {
          "name": "0.454%Stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe",
          "type": "DRUG"
        },
        {
          "name": "0.76% Sodium Monofluorophosphate (Na MFP) toothpaste",
          "type": "DRUG"
        },
        {
          "name": "0.022% Sodium Fluoride mouthwash",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 134,
      "start_date": "2026-01-26",
      "completion_date": "2026-04-29",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07398846"
    },
    {
      "nct_id": "NCT01881074",
      "title": "Periodontal Treatment Response in Type II Diabetic Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Type II Diabetes",
        "Periodontal Disease"
      ],
      "interventions": [
        {
          "name": "Triclosan containing toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Non-triclosan containing toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 74,
      "start_date": "2012-06",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2018-09-17",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01881074"
    },
    {
      "nct_id": "NCT06136455",
      "title": "A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Listerine Clinical Solutions Teeth Strength",
          "type": "DRUG"
        },
        {
          "name": "Listerine Total Care Zero Alcohol Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "Listerine Cool Mint Zero Alcohol Mouthwash",
          "type": "OTHER"
        },
        {
          "name": "Colgate Cavity Protection Toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 164,
      "start_date": "2023-11-13",
      "completion_date": "2023-11-16",
      "has_results": false,
      "last_update_posted_date": "2024-01-03",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06136455"
    },
    {
      "nct_id": "NCT07738198",
      "title": "Dentin Hypersensitivity Reduction Efficacy Clinical",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Hypersensitivity"
      ],
      "interventions": [
        {
          "name": "0.454% stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "5% potassium nitrate",
          "type": "DRUG"
        },
        {
          "name": "0.76% sodium monofluorophosphate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 116,
      "start_date": "2018-11-26",
      "completion_date": "2018-12-08",
      "has_results": false,
      "last_update_posted_date": "2026-07-31",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Costa Mesa, California",
      "locations": [
        {
          "city": "Costa Mesa",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07738198"
    },
    {
      "nct_id": "NCT07029438",
      "title": "Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dental Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "Floss",
          "type": "DEVICE"
        },
        {
          "name": "Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "Toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 228,
      "start_date": "2025-07-07",
      "completion_date": "2025-10-16",
      "has_results": false,
      "last_update_posted_date": "2025-10-30",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07029438"
    },
    {
      "nct_id": "NCT04696536",
      "title": "A Twelve Week Study of Supervised Mouth Rinse and Flossing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Colgate Cavity Protection Toothpaste",
          "type": "OTHER"
        },
        {
          "name": "American Dental Association (ADA) Referenced Toothbrush",
          "type": "OTHER"
        },
        {
          "name": "5% Hydroalcohol Mouth Rinse",
          "type": "OTHER"
        },
        {
          "name": "REACH Dental Floss",
          "type": "OTHER"
        },
        {
          "name": "Alcohol-containing Essential Oil (AEO) Mouth Rinse (Listerine Cool Mint, marketed)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 149,
      "start_date": "2018-09-26",
      "completion_date": "2018-12-21",
      "has_results": false,
      "last_update_posted_date": "2021-09-28",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04696536"
    },
    {
      "nct_id": "NCT01641237",
      "title": "Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Enamel Erosion"
      ],
      "interventions": [
        {
          "name": "sodium fluoride",
          "type": "DRUG"
        },
        {
          "name": "no added fluoride in a silica base",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 72,
      "start_date": "2012-03",
      "completion_date": "2012-05",
      "has_results": true,
      "last_update_posted_date": "2014-07-24",
      "last_synced_at": "2026-09-29T04:11:23.975Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01641237"
    }
  ]
}