{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Spinal+Manipulation+Therapy+%28SMT%29",
    "query": {
      "intervention": "Spinal Manipulation Therapy (SMT)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Spinal+Manipulation+Therapy+%28SMT%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-10-02T02:29:04.106Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01894282",
      "title": "Mind Body Intervention for Chronic Lower Back Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Chronic Lower Back Pain"
      ],
      "interventions": [
        {
          "name": "Manual Therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Mind Body Intervention",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Canandaigua VA Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "18 Years to 69 Years"
      },
      "enrollment_count": 4,
      "start_date": "2013-07",
      "completion_date": "2017-11",
      "has_results": false,
      "last_update_posted_date": "2022-03-31",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01894282"
    },
    {
      "nct_id": "NCT06312696",
      "title": "Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neck Pain"
      ],
      "interventions": [
        {
          "name": "SMT",
          "type": "OTHER"
        },
        {
          "name": "Light Massage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "18 Years to 39 Years"
      },
      "enrollment_count": 60,
      "start_date": "2024-04-01",
      "completion_date": "2027-04-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-06",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06312696"
    },
    {
      "nct_id": "NCT01406847",
      "title": "Central Mechanisms of Intervention for Low Back Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Spinal Manipulation",
          "type": "OTHER"
        },
        {
          "name": "Spinal Mobilization",
          "type": "OTHER"
        },
        {
          "name": "Static Touch",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 159,
      "start_date": "2012-08",
      "completion_date": "2017-05-01",
      "has_results": false,
      "last_update_posted_date": "2018-04-05",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01406847"
    },
    {
      "nct_id": "NCT02868034",
      "title": "Optimization of Spinal Manipulative Therapy Protocols",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "SMT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobilizing Exercises",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Activation Exercises",
          "type": "BEHAVIORAL"
        },
        {
          "name": "SMT extended",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 273,
      "start_date": "2017-02-22",
      "completion_date": "2019-01-12",
      "has_results": true,
      "last_update_posted_date": "2023-05-17",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02868034"
    },
    {
      "nct_id": "NCT05022121",
      "title": "Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Back Pain",
        "Sciatica",
        "Back Related Leg Pain",
        "Pain, Chronic",
        "Intervertebral Disc Displacement"
      ],
      "interventions": [
        {
          "name": "Supported Biopsychosocial Self-Management (SBSM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Medical Care",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2022-01-26",
      "completion_date": "2023-02-20",
      "has_results": true,
      "last_update_posted_date": "2024-03-15",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 2,
      "location_summary": "Minneapolis, Minnesota • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05022121"
    },
    {
      "nct_id": "NCT03669354",
      "title": "Spinal Manipulation Services vs. Prescription Drug Therapy for Long-term Care",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Low Back Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Southern California University of Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "64 Years",
        "maximum_age": "84 Years",
        "sex": "ALL",
        "summary": "64 Years to 84 Years"
      },
      "enrollment_count": 195,
      "start_date": "2019-05-01",
      "completion_date": "2020-06-30",
      "has_results": true,
      "last_update_posted_date": "2021-09-23",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Whittier, California",
      "locations": [
        {
          "city": "Whittier",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03669354"
    },
    {
      "nct_id": "NCT00284063",
      "title": "Z-Joint Changes in Low Back Pain Following Adjusting",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Low back adjustment and MRI",
          "type": "PROCEDURE"
        },
        {
          "name": "MRI",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "National University of Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "21 Years to 69 Years"
      },
      "enrollment_count": 112,
      "start_date": "2006-01-31",
      "completion_date": "2010-09-30",
      "has_results": false,
      "last_update_posted_date": "2022-05-12",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Lombard, Illinois",
      "locations": [
        {
          "city": "Lombard",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00284063"
    },
    {
      "nct_id": "NCT04142177",
      "title": "Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Pain EASE",
          "type": "OTHER"
        },
        {
          "name": "Tailored exercise",
          "type": "PROCEDURE"
        },
        {
          "name": "Continued Care and Active Monitoring",
          "type": "OTHER"
        },
        {
          "name": "Cognitive Behavioral Therapy (CBT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Spinal Manipulation Therapy (SMT)",
          "type": "PROCEDURE"
        },
        {
          "name": "Yoga",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2529,
      "start_date": "2022-06-13",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-04",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 19,
      "location_summary": "Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04142177"
    },
    {
      "nct_id": "NCT03749564",
      "title": "Influence of Opioid Use on the Effects of Spinal Manipulative Therapy for Low Back Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Back Pain",
        "Opioid Use"
      ],
      "interventions": [
        {
          "name": "SMT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Activation Exercises",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobilizing Exercises",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Extended SMT",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 7,
      "start_date": "2019-01-17",
      "completion_date": "2020-03-03",
      "has_results": false,
      "last_update_posted_date": "2022-09-22",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03749564"
    },
    {
      "nct_id": "NCT03581123",
      "title": "Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Acute Pain",
        "Low Back Pain, Mechanical"
      ],
      "interventions": [
        {
          "name": "Supported-Self Management (SSM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Spinal Manipulation Therapy (SMT)",
          "type": "OTHER"
        },
        {
          "name": "SMT + SSM",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Standard Medical Care (SMC)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER",
        "COMBINATION_PRODUCT",
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2018-11-01",
      "completion_date": "2024-06-12",
      "has_results": true,
      "last_update_posted_date": "2025-10-16",
      "last_synced_at": "2026-10-02T02:29:04.106Z",
      "location_count": 3,
      "location_summary": "Minneapolis, Minnesota • Pittsburgh, Pennsylvania • Seattle, Washington",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03581123"
    }
  ]
}