{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sporozoite+challenge&page=2", "query": { "intervention": "Sporozoite challenge", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 31, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sporozoite+challenge&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Sporozoite+challenge&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-03T22:52:54.404Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03824236", "title": "A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "RTS,S/AS01E (SB257049)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 61, "start_date": "2019-02-05", "completion_date": "2019-09-26", "has_results": true, "last_update_posted_date": "2020-08-14", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03824236" }, { "nct_id": "NCT01441167", "title": "Experimental PfSPZ Vaccine in Adults Without Malaria", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria", "Prevention and Control", "Acquired Immunity" ], "interventions": [ { "name": "PfSPZ", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 64, "start_date": "2011-09-14", "completion_date": "2013-06-05", "has_results": false, "last_update_posted_date": "2018-07-05", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01441167" }, { "nct_id": "NCT06735209", "title": "First-in-Human PfSPZ-LARC2 Vaccination/CHMI", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "PfSPZ (7G8) Challenge", "type": "BIOLOGICAL" }, { "name": "Sodium Chloride, 0.9%", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 22, "start_date": "2025-07-23", "completion_date": "2026-07-10", "has_results": false, "last_update_posted_date": "2026-08-17", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT06735209" }, { "nct_id": "NCT04966871", "title": "Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "PfSPZ Challenge (7G8) for CHMI", "type": "BIOLOGICAL" }, { "name": "Normal Saline", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Sanaria Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 54, "start_date": "2021-09-27", "completion_date": "2022-06-21", "has_results": false, "last_update_posted_date": "2022-07-18", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04966871" }, { "nct_id": "NCT01500980", "title": "Malaria Challenge in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "P. falciparum infection", "type": "BIOLOGICAL" }, { "name": "Chloroquine", "type": "DRUG" }, { "name": "Primaquine", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Seattle Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 36, "start_date": "2011-12", "completion_date": "2012-11", "has_results": false, "last_update_posted_date": "2012-12-13", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT01500980" }, { "nct_id": "NCT01994525", "title": "Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfRAS", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" }, { "name": "Challenge", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 54, "start_date": "2014-01-24", "completion_date": "2017-02", "has_results": false, "last_update_posted_date": "2019-09-17", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01994525" }, { "nct_id": "NCT03882528", "title": "Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria,Falciparum" ], "interventions": [ { "name": "Plasmodium falciparum malaria parasite", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 12, "start_date": "2019-03-04", "completion_date": "2019-05-16", "has_results": true, "last_update_posted_date": "2021-03-30", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03882528" }, { "nct_id": "NCT02562872", "title": "DSM265 Prophylaxis of Plasmodium Falciparum Malaria", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "DSM265", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Sporozoites", "type": "BIOLOGICAL" }, { "name": "Infective mosquito bite", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "Medicines for Malaria Venture", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 24, "start_date": "2016-03", "completion_date": "2017-05", "has_results": false, "last_update_posted_date": "2022-01-14", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT02562872" }, { "nct_id": "NCT01058226", "title": "Reproducibility of Malaria Challenge in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Malaria challenge (wild-type NF54 strain Plasmodium falciparum sporozoites)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Seattle Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 6, "start_date": "2010-02", "completion_date": "2010-09", "has_results": false, "last_update_posted_date": "2011-03-31", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT01058226" }, { "nct_id": "NCT02174978", "title": "Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "FMP012 with AS01B adjuvant system", "type": "BIOLOGICAL" }, { "name": "P falciparum Controlled Human Malaria Infection (CHMI)", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 39, "start_date": "2014-08", "completion_date": "2015-10", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-10-03T22:52:54.404Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02174978" } ] }