{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Standard+Below+Knee+Amputation",
    "query": {
      "intervention": "Standard Below Knee Amputation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-17T11:34:00.917Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06391697",
      "title": "Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation"
      ],
      "interventions": [
        {
          "name": "eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 7,
      "start_date": "2024-05-01",
      "completion_date": "2027-05-02",
      "has_results": false,
      "last_update_posted_date": "2026-07-09",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06391697"
    },
    {
      "nct_id": "NCT05140499",
      "title": "Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pain, Postoperative",
        "Amputation"
      ],
      "interventions": [
        {
          "name": "Liposomal bupivacaine",
          "type": "DRUG"
        },
        {
          "name": "Bupivacaine Hydrochloride 0.5 % Injectable Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Aurora Quaye",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 11,
      "start_date": "2022-08-15",
      "completion_date": "2025-12-23",
      "has_results": true,
      "last_update_posted_date": "2026-01-27",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Portland, Maine",
      "locations": [
        {
          "city": "Portland",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05140499"
    },
    {
      "nct_id": "NCT07159490",
      "title": "Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Prosthesis User"
      ],
      "interventions": [
        {
          "name": "Standard-of-care prosthetic foot",
          "type": "DEVICE"
        },
        {
          "name": "Standard-of-care prosthetic foot with heel-stiffening wedge",
          "type": "DEVICE"
        },
        {
          "name": "Standard-of-care prosthetic foot of one category greater stiffness",
          "type": "DEVICE"
        },
        {
          "name": "Dual keel prosthetic foot",
          "type": "DEVICE"
        },
        {
          "name": "Powered ankle-foot",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Puget Sound Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 13,
      "start_date": "2020-12-03",
      "completion_date": "2025-10-01",
      "has_results": true,
      "last_update_posted_date": "2026-02-12",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07159490"
    },
    {
      "nct_id": "NCT06906055",
      "title": "Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peripheral Arterial Disease Below the Knee",
        "Peripheral Arterial Disease, Rutherford 4 and 5 with Possibility to Improve Vascularization"
      ],
      "interventions": [
        {
          "name": "Multicath",
          "type": "DEVICE"
        },
        {
          "name": "Standard of Care (SOC)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Summa Therapeutics, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 24,
      "start_date": "2025-04-03",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-04-02",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 2,
      "location_summary": "Wilmington, Delaware • Vineland, New Jersey",
      "locations": [
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Vineland",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06906055"
    },
    {
      "nct_id": "NCT06711588",
      "title": "Automatic Prosthetic Foot Stiffness Modulation to Improve Balance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation Below Knee"
      ],
      "interventions": [
        {
          "name": "As-prescribed stiffness",
          "type": "DEVICE"
        },
        {
          "name": "Two categories stiffer than the as-prescribed stiffness",
          "type": "DEVICE"
        },
        {
          "name": "Two categories less stiff than the as-prescribed stiffness",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Seattle Institute for Biomedical and Clinical Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 21,
      "start_date": "2024-12-19",
      "completion_date": "2026-07-24",
      "has_results": false,
      "last_update_posted_date": "2026-08-07",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06711588"
    },
    {
      "nct_id": "NCT05437562",
      "title": "Randomized Clinical Trial for Ewing Amputation in the VA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peripheral Arterial Disease"
      ],
      "interventions": [
        {
          "name": "Ewing Below Knee Amputation",
          "type": "PROCEDURE"
        },
        {
          "name": "Standard Below Knee Amputation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 120,
      "start_date": "2026-02-02",
      "completion_date": "2030-02-02",
      "has_results": false,
      "last_update_posted_date": "2026-02-09",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 3,
      "location_summary": "Decatur, Georgia • Nashville, Tennessee • Houston, Texas",
      "locations": [
        {
          "city": "Decatur",
          "state": "Georgia"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05437562"
    },
    {
      "nct_id": "NCT03900845",
      "title": "Adherence and Perspiration While Wearing Lower Limb Prostheses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Extremity Amputation"
      ],
      "interventions": [
        {
          "name": "Dynamic Air Exchange - Rising Edge Design (DAE-RED)",
          "type": "DEVICE"
        },
        {
          "name": "Perforated elastomeric liner",
          "type": "DEVICE"
        },
        {
          "name": "As-prescribed prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Seattle Institute for Biomedical and Clinical Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 20,
      "start_date": "2019-02-17",
      "completion_date": "2022-06-28",
      "has_results": true,
      "last_update_posted_date": "2026-01-27",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03900845"
    },
    {
      "nct_id": "NCT05190354",
      "title": "Post Market Clinical Protocol - Xtremity Polymer Prosthetic Socket System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Prosthesis User"
      ],
      "interventions": [
        {
          "name": "Xtremity Polymer Prosthetic Socket",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medical Creations, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2021-11-16",
      "completion_date": "2022-06-24",
      "has_results": false,
      "last_update_posted_date": "2022-08-24",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05190354"
    },
    {
      "nct_id": "NCT02685098",
      "title": "A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Ischemia",
        "Peripheral Arterial Disease",
        "Peripheral Vascular Disease",
        "Vascular Disease",
        "Arterial Occlusive Disease",
        "Arteriosclerosis",
        "Atherosclerosis",
        "Cardiovascular Disease",
        "Pathologic Processes",
        "Orthopedic Procedures",
        "Amputation"
      ],
      "interventions": [
        {
          "name": "Allogeneic bone marrow derived mesenchymal stem cells",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "40 Years to 90 Years"
      },
      "enrollment_count": 81,
      "start_date": "2017-01-23",
      "completion_date": "2023-10-03",
      "has_results": false,
      "last_update_posted_date": "2025-09-23",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02685098"
    },
    {
      "nct_id": "NCT07791433",
      "title": "Automatic Prosthetic Foot Stiffness Modulation to Improve Balance in the Real World",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation Below Knee"
      ],
      "interventions": [
        {
          "name": "Fixed stiffness prosthesis",
          "type": "DEVICE"
        },
        {
          "name": "Automatic stiffness prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Seattle Institute for Biomedical and Clinical Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "18 Years to 79 Years"
      },
      "enrollment_count": 20,
      "start_date": "2026-11",
      "completion_date": "2028-11",
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-09-17T11:34:00.917Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07791433"
    }
  ]
}