{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Standard+of+Care+weaning&page=2", "query": { "intervention": "Standard of Care weaning", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 39, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Standard+of+Care+weaning&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Standard+of+Care+weaning&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-30T04:55:16.232Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07452406", "title": "Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acute Hypoxemic Respiratory Failure", "High-Flow Nasal Cannula Therapy" ], "interventions": [ { "name": "Protocolized HFNC Weaning Strategy", "type": "BEHAVIORAL" }, { "name": "Usual Care HFNC Weaning", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Rush University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2000, "start_date": "2026-11-01", "completion_date": "2028-06-28", "has_results": false, "last_update_posted_date": "2026-09-25", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT07452406" }, { "nct_id": "NCT06525818", "title": "Let's E.A.T.! (Eating With Assistive Technology): An Intervention to Support Children With Feeding Tubes and Tracheostomies", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Feeding Tube", "Children With Medical Complexity", "Tracheostomy", "Feeding Disorder, Infancy or Early Childhood" ], "interventions": [ { "name": "Tube weaning therapy intervention", "type": "OTHER" }, { "name": "Feeding Group", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "3 Years", "sex": "ALL", "summary": "Up to 3 Years" }, "enrollment_count": 40, "start_date": "2024-07-08", "completion_date": "2027-07-07", "has_results": false, "last_update_posted_date": "2026-09-08", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT06525818" }, { "nct_id": "NCT05998018", "title": "Randomized Study of the pdSTIM™ System in Failure to Wean Mechanically Ventilated Patients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Neuromodulation", "Phrenic Nerve Stimulation", "Ventilator Induced Diaphragm Dysfunction", "Mechanical Ventilation Weaning" ], "interventions": [ { "name": "pdSTIM System Therapy", "type": "DEVICE" }, { "name": "Conventional Medical Management", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Stimdia Medical Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2023-09-29", "completion_date": "2025-09-04", "has_results": false, "last_update_posted_date": "2026-03-27", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 21, "location_summary": "Mobile, Alabama • Chandler, Arizona • Goodyear, Arizona + 18 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Goodyear", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05998018" }, { "nct_id": "NCT07123961", "title": "Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial", "overall_status": "SUSPENDED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Respiratory Distress Syndrome (ARDS)", "Ventilator Management", "Lung-protective Ventilation", "Pediatric Acute Respiratory Distress Syndrome (PARDS)" ], "interventions": [ { "name": "High Driving Pressure Mechanical Ventilation", "type": "OTHER" }, { "name": "Low Driving Pressure Mechanical Ventilation", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Weeks", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Weeks to 17 Years" }, "enrollment_count": 160, "start_date": "2025-11-07", "completion_date": "2030-06-30", "has_results": false, "last_update_posted_date": "2026-08-14", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT07123961" }, { "nct_id": "NCT00464490", "title": "Use of Dexmedetomidine to Facilitate Extubation in Surgical ICU Patients Who Failed Previous Weaning Attempts", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Intubation; Difficult", "Respiration Disorders" ], "interventions": [ { "name": "Dexmedetomidine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "69 Years", "sex": "ALL", "summary": "18 Years to 69 Years" }, "enrollment_count": 42, "start_date": "2007-11", "completion_date": "2012-12", "has_results": true, "last_update_posted_date": "2014-10-31", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00464490" }, { "nct_id": "NCT03951064", "title": "Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Obesity, Morbid", "Ventilator-Induced Lung Injury", "Respiratory Failure" ], "interventions": [ { "name": "Esophageal balloon", "type": "DEVICE" }, { "name": "Intervention Spontaneous Breathing Trial (SBT) and Extubation", "type": "PROCEDURE" }, { "name": "Control Spontaneous Breathing Trial and Extubation", "type": "PROCEDURE" }, { "name": "Intervention Weaning after Tracheostomy", "type": "PROCEDURE" }, { "name": "Control Weaning after Tracheostomy", "type": "PROCEDURE" } ], "intervention_types": [ "DEVICE", "PROCEDURE" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6, "start_date": "2021-03-31", "completion_date": "2022-12-06", "has_results": true, "last_update_posted_date": "2024-06-05", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 2, "location_summary": "Chapel Hill, North Carolina • Greenville, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Greenville", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03951064" }, { "nct_id": "NCT01678937", "title": "Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Liver Transplant Rejection", "Immunosuppression" ], "interventions": [ { "name": "Blood Draw - Rapamycin", "type": "PROCEDURE" }, { "name": "Blood Draw from Control Subjects", "type": "PROCEDURE" }, { "name": "Blood Draw - CyA", "type": "PROCEDURE" }, { "name": "Blood Draw - Tacrolimus", "type": "PROCEDURE" }, { "name": "Blood Draw - MMF", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Northwestern University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2007-09", "completion_date": "2008-09", "has_results": false, "last_update_posted_date": "2015-04-15", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01678937" }, { "nct_id": "NCT05440851", "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Insufficiency", "Extracorporeal Membrane Oxygenation Complication", "Mechanical Ventilation Pressure High" ], "interventions": [ { "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support", "type": "OTHER" }, { "name": "Lung-Protective Ventilation (LPV)", "type": "OTHER" }, { "name": "Driving Pressure-Limited Ventilation (DPL)", "type": "OTHER" }, { "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)", "type": "OTHER" }, { "name": "Early Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Extended Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Usual care without routine corticosteroids", "type": "DRUG" }, { "name": "Usual care without extending corticosteroids", "type": "DRUG" }, { "name": "Usual care with fludrocortisone", "type": "DRUG" }, { "name": "Usual care without fludrocortisone", "type": "DRUG" }, { "name": "Drug 4 mL:", "type": "DRUG" }, { "name": "Drug 40 mg:", "type": "DRUG" }, { "name": "PEEP-20", "type": "OTHER" }, { "name": "PEEP-AOP", "type": "OTHER" }, { "name": "PEEP-10", "type": "OTHER" }, { "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation", "type": "OTHER" }, { "name": "Electrical impedance tomography (EIT)", "type": "OTHER" }, { "name": "no treatment / intervention arm is involved.", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Early Routine IMT", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "University Health Network, Toronto", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6250, "start_date": "2023-04-30", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-05-07", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 26, "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05440851" }, { "nct_id": "NCT05076110", "title": "Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hip Arthroscopy" ], "interventions": [ { "name": "Oxycodone", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Methocarbamol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 86, "start_date": "2022-04-07", "completion_date": "2025-10-25", "has_results": true, "last_update_posted_date": "2026-06-03", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT05076110" }, { "nct_id": "NCT04548596", "title": "NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Traumatic Brain Injury", "Subarachnoid Hemorrhage", "Intracerebral Hemorrhage", "Liver Failure", "Ischemic Stroke" ], "interventions": [ { "name": "Transcranial Doppler", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 162, "start_date": "2014-09-10", "completion_date": "2025-04-30", "has_results": false, "last_update_posted_date": "2025-09-18", "last_synced_at": "2026-09-30T04:55:16.232Z", "location_count": 3, "location_summary": "Davis, California • San Francisco, California • Atlanta, Georgia", "locations": [ { "city": "Davis", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT04548596" } ] }