{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Surgical+Valve+Replacement&page=3",
    "query": {
      "intervention": "Surgical Valve Replacement",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 128,
    "total_pages": 13,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Surgical+Valve+Replacement&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Surgical+Valve+Replacement&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-03T12:49:45.099Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00636987",
      "title": "Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Insufficiency",
        "Aortic Valve Regurgitation",
        "Aortic Valve Stenosis",
        "Aortic Valve Incompetence",
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Stenosis",
        "Mitral Valve Incompetence"
      ],
      "interventions": [
        {
          "name": "Biocor and Biocor Supra valves",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 297,
      "start_date": "2007-04",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2019-02-04",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 17,
      "location_summary": "La Jolla, California • Los Angeles, California • Evansville, Indiana + 14 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Evansville",
          "state": "Indiana"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Portland",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00636987"
    },
    {
      "nct_id": "NCT03836521",
      "title": "Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bicuspid Aortic Valve"
      ],
      "interventions": [
        {
          "name": "Transcatheter aortic valve replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "129 Years",
        "sex": "ALL",
        "summary": "19 Years to 129 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2016-08-15",
      "completion_date": "2028-08-15",
      "has_results": false,
      "last_update_posted_date": "2019-02-11",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03836521"
    },
    {
      "nct_id": "NCT03693261",
      "title": "Epicardial Fat in Coronary Artery Disease",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "Coronary artery bypass grafting (CABG)",
          "type": "PROCEDURE"
        },
        {
          "name": "Valve replacement",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "50 Years to 75 Years"
      },
      "enrollment_count": 43,
      "start_date": "2011-12-18",
      "completion_date": "2019-04-15",
      "has_results": false,
      "last_update_posted_date": "2019-04-17",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03693261"
    },
    {
      "nct_id": "NCT05452720",
      "title": "MASA Valve Early Feasibility Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tetrology of Fallot",
        "Pulmonary Stenosis",
        "Truncus Arteriosus",
        "Transposition of Great Vessels",
        "Pulmonary Atresia",
        "Ross Procedure"
      ],
      "interventions": [
        {
          "name": "Surgical Right Ventricular Outflow Tract Reconstruction",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "PECA Labs",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": "22 Years",
        "sex": "ALL",
        "summary": "0 Years to 22 Years"
      },
      "enrollment_count": 10,
      "start_date": "2023-05-18",
      "completion_date": "2028-04-01",
      "has_results": false,
      "last_update_posted_date": "2024-11-06",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 5,
      "location_summary": "Peoria, Illinois • Boston, Massachusetts • Cincinnati, Ohio + 2 more",
      "locations": [
        {
          "city": "Peoria",
          "state": "Illinois"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05452720"
    },
    {
      "nct_id": "NCT04688190",
      "title": "CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mitral Regurgitation",
        "Mitral Valve Disease",
        "Mitral Annular Calcification"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Universitätsklinikum Hamburg-Eppendorf",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2020-11-01",
      "completion_date": "2030-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 9,
      "location_summary": "Tucson, Arizona • Los Angeles, California • Tampa, Florida + 6 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04688190"
    },
    {
      "nct_id": "NCT05258942",
      "title": "MyLeukoMAP™ Genomic Survival Prediction Assay Pivotal Clinical Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Observational",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "LeukoLifeDx Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2022-07-01",
      "completion_date": "2023-08",
      "has_results": false,
      "last_update_posted_date": "2022-10-27",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 3,
      "location_summary": "New Haven, Connecticut • Orlando, Florida • Kansas City, Missouri",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05258942"
    },
    {
      "nct_id": "NCT00581399",
      "title": "A Randomized Multicenter Clinical Study On the High Vacuum Body Cavity Drainage System Following Open Heart Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Heart Valve Disease"
      ],
      "interventions": [
        {
          "name": "NO-NUMO™ High Vacuum Body Cavity Drainage System",
          "type": "DEVICE"
        },
        {
          "name": "PVC Chest Tube",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 94,
      "start_date": "2006-09",
      "completion_date": "2010-09",
      "has_results": true,
      "last_update_posted_date": "2011-10-31",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 1,
      "location_summary": "Orange, California",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00581399"
    },
    {
      "nct_id": "NCT06590467",
      "title": "Abbott Structural Heart Device Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Heart Diseases",
        "ASD - Atrial Septal Defect",
        "VSD - Muscular Ventricular Septal Defect",
        "PFO - Patent Foramen Ovale",
        "PIVSD - Post Infarct Muscular Ventricular Septal Defect",
        "Valvular Heart Disease"
      ],
      "interventions": [
        {
          "name": "Amplatzer™ Occlusion Devices",
          "type": "DEVICE"
        },
        {
          "name": "Epic™ Surgical Tissue Heart Valve devices",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 2500,
      "start_date": "2024-08-21",
      "completion_date": "2039-11",
      "has_results": false,
      "last_update_posted_date": "2026-09-01",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 13,
      "location_summary": "Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06590467"
    },
    {
      "nct_id": "NCT04545502",
      "title": "PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aneurysm",
        "Dissection",
        "Aortic Root Aneurysm",
        "Aortic Root Dissection",
        "Carotid Artery Injuries",
        "Aortic Arch",
        "Bypass Extremity Graft",
        "Occlusive Vascular Disease",
        "Aortic Diseases"
      ],
      "interventions": [
        {
          "name": "Gelsoft Plus Vascular Graft",
          "type": "DEVICE"
        },
        {
          "name": "Vascular Bypass Graft",
          "type": "DEVICE"
        },
        {
          "name": "Cardiovascular Patch",
          "type": "DEVICE"
        },
        {
          "name": "Gelweave Vascular Graft",
          "type": "DEVICE"
        },
        {
          "name": "Gelweave Valsalva Vascular Graft",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vascutek Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2021-02-17",
      "completion_date": "2037-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-20",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 10,
      "location_summary": "Aurora, Colorado • Tampa, Florida • Indianapolis, Indiana + 7 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Greenville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04545502"
    },
    {
      "nct_id": "NCT01812174",
      "title": "On-X Heart Valve - 17mm Aortic and 23mm Mitral",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Valve Disease"
      ],
      "interventions": [
        {
          "name": "17mm aortic valve (On-X )",
          "type": "DEVICE"
        },
        {
          "name": "23mm mitral valve (On-X)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "On-X Life Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2011-11-18",
      "completion_date": "2018-12-07",
      "has_results": true,
      "last_update_posted_date": "2024-03-06",
      "last_synced_at": "2026-10-03T12:49:45.099Z",
      "location_count": 7,
      "location_summary": "Little Rock, Arkansas • Portland, Maine • Las Vegas, Nevada + 4 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Portland",
          "state": "Maine"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01812174"
    }
  ]
}