{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Symplicity+Renal+Denervation",
    "query": {
      "intervention": "Symplicity Renal Denervation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T16:38:28.555Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00753285",
      "title": "Renal Denervation in Patients With Refractory Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Renal Denervation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2008-09",
      "completion_date": "2013-05",
      "has_results": false,
      "last_update_posted_date": "2014-11-10",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 3,
      "location_summary": "Springfield, Illinois • Minneapolis, Minnesota • Cleveland, Ohio",
      "locations": [
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00753285"
    },
    {
      "nct_id": "NCT02439775",
      "title": "SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension",
        "Vascular Diseases",
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "Symplicity Spyral™ multi-electrode renal denervation system",
          "type": "DEVICE"
        },
        {
          "name": "Sham Procedure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 337,
      "start_date": "2015-07-22",
      "completion_date": "2025-08-14",
      "has_results": true,
      "last_update_posted_date": "2026-07-30",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 32,
      "location_summary": "Huntsville, Alabama • Stanford, California • New Haven, Connecticut + 26 more",
      "locations": [
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02439775"
    },
    {
      "nct_id": "NCT02064764",
      "title": "Renal Nerve Denervation in Patients With Hypertension and Paroxysmal and Persistent Atrial Fibrillation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Atrial Fibrillation",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Symplicity Spyral™ Multi-Electrode Renal Denervation Catheter",
          "type": "DEVICE"
        },
        {
          "name": "Arctic Front Advance™ Cardiac Cryoablation System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 102,
      "start_date": "2015-02",
      "completion_date": "2021-04-19",
      "has_results": true,
      "last_update_posted_date": "2024-02-23",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 9,
      "location_summary": "Sacramento, California • Burlington, Massachusetts • Marquette, Michigan + 5 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Burlington",
          "state": "Massachusetts"
        },
        {
          "city": "Marquette",
          "state": "Michigan"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02064764"
    },
    {
      "nct_id": "NCT05198674",
      "title": "SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension",
        "Vascular Diseases",
        "Cardiovascular Diseases",
        "Chronic Kidney Diseases",
        "Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Renal Denervation (Symplicity Spyral™)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1899,
      "start_date": "2021-10-20",
      "completion_date": "2029-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-09-14",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 76,
      "location_summary": "Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 67 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05198674"
    },
    {
      "nct_id": "NCT04311086",
      "title": "SPYRAL DYSTAL Renal Denervation Global Clinical Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension",
        "Vascular Diseases",
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "Renal Denervation (Symplicity Spyral™)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 128,
      "start_date": "2020-06-12",
      "completion_date": "2022-12-22",
      "has_results": true,
      "last_update_posted_date": "2024-04-17",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 3,
      "location_summary": "Stanford, California • Atlanta, Georgia • Dallas, Texas",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04311086"
    },
    {
      "nct_id": "NCT02439749",
      "title": "SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension",
        "Vascular Diseases",
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "Symplicity Spyral™ multi-electrode renal denervation system",
          "type": "DEVICE"
        },
        {
          "name": "Sham Procedure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 366,
      "start_date": "2015-06",
      "completion_date": "2023-10-25",
      "has_results": true,
      "last_update_posted_date": "2025-03-28",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 30,
      "location_summary": "Huntsville, Alabama • Scottsdale, Arizona • Los Angeles, California + 26 more",
      "locations": [
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02439749"
    },
    {
      "nct_id": "NCT07174622",
      "title": "Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypertension",
        "Cardiovascular Diseases",
        "Vascular Diseases"
      ],
      "interventions": [
        {
          "name": "Renal Denervation (Symplicity Spyral™)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2025-10-28",
      "completion_date": "2029-06",
      "has_results": false,
      "last_update_posted_date": "2026-04-22",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07174622"
    },
    {
      "nct_id": "NCT01954160",
      "title": "Study of Renal Denervation in Patients With Heart Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Symplicity Renal Denervation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Adrian Hernandez",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 5,
      "start_date": "2013-12",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2016-02-02",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 12,
      "location_summary": "Atlanta, Georgia • Boston, Massachusetts • Rochester, Minnesota + 5 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01954160"
    },
    {
      "nct_id": "NCT01972139",
      "title": "Renal Denervation in Patients With Uncontrolled Hypertension - SYMPLICITY HTN-4",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension",
        "Vascular Diseases",
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "Renal Denervation using the Symplicity Renal Denervation System",
          "type": "DEVICE"
        },
        {
          "name": "Sham Renal Denervation",
          "type": "OTHER"
        },
        {
          "name": "Renal Angiography",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 44,
      "start_date": "2013-10",
      "completion_date": "2017-01",
      "has_results": false,
      "last_update_posted_date": "2017-04-26",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 3,
      "location_summary": "Atlanta, Georgia • Durham, North Carolina • Charleston, South Carolina",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01972139"
    },
    {
      "nct_id": "NCT01418261",
      "title": "SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Uncontrolled Hypertension"
      ],
      "interventions": [
        {
          "name": "Renal denervation (Symplicity Catheter System)",
          "type": "DEVICE"
        },
        {
          "name": "Renal angiogram",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Medtronic Vascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 535,
      "start_date": "2011-09",
      "completion_date": "2017-02-17",
      "has_results": false,
      "last_update_posted_date": "2017-04-26",
      "last_synced_at": "2026-09-29T16:38:28.555Z",
      "location_count": 79,
      "location_summary": "Birmingham, Alabama • La Jolla, California • Los Angeles, California + 61 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01418261"
    }
  ]
}