{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=THR-149+dose+level+3",
    "query": {
      "intervention": "THR-149 dose level 3"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 2,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T03:08:07.879Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03511898",
      "title": "A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Diabetes Mellitus",
        "Diabetic Retinopathy",
        "Diabetic Macular Edema"
      ],
      "interventions": [
        {
          "name": "THR-149 dose level 1",
          "type": "DRUG"
        },
        {
          "name": "THR-149 dose level 2",
          "type": "DRUG"
        },
        {
          "name": "THR-149 dose level 3",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ThromboGenics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2018-05-18",
      "completion_date": "2019-05-22",
      "has_results": false,
      "last_update_posted_date": "2019-06-13",
      "last_synced_at": "2026-09-10T03:08:07.879Z",
      "location_count": 7,
      "location_summary": "Phoenix, Arizona • Boston, Massachusetts • Reno, Nevada + 4 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Reno",
          "state": "Nevada"
        },
        {
          "city": "Huntingdon Valley",
          "state": "Pennsylvania"
        },
        {
          "city": "Abilene",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03511898"
    },
    {
      "nct_id": "NCT04527107",
      "title": "A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Diabetes Mellitus",
        "Diabetic Retinopathy",
        "Diabetic Macular Edema"
      ],
      "interventions": [
        {
          "name": "THR-149 dose level 1",
          "type": "DRUG"
        },
        {
          "name": "THR-149 dose level 2",
          "type": "DRUG"
        },
        {
          "name": "THR-149 dose level 3",
          "type": "DRUG"
        },
        {
          "name": "THR-149 0.13mg",
          "type": "DRUG"
        },
        {
          "name": "THR-149 0.13mg + aflibercept 2mg",
          "type": "DRUG"
        },
        {
          "name": "aflibercept 2mg + THR-149 0.13mg",
          "type": "DRUG"
        },
        {
          "name": "Aflibercept 2mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oxurion",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 135,
      "start_date": "2020-07-31",
      "completion_date": "2023-11-22",
      "has_results": false,
      "last_update_posted_date": "2023-11-27",
      "last_synced_at": "2026-09-10T03:08:07.879Z",
      "location_count": 41,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • Beverly Hills, California + 32 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Huntington Beach",
          "state": "California"
        },
        {
          "city": "Mountain View",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04527107"
    }
  ]
}