{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=TUS+Sham",
    "query": {
      "intervention": "TUS Sham"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 11,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=TUS+Sham&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-05T03:37:25.916Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07767006",
      "title": "Neuromodulation for Patients With Parkinson's Disease",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adults With Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "tDCS combined with TUS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Felipe Fregni, MD, PhD, MPH",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "40 Years to 85 Years"
      },
      "enrollment_count": 116,
      "start_date": "2026-10-01",
      "completion_date": "2032-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-17",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07767006"
    },
    {
      "nct_id": "NCT02330315",
      "title": "Effects of tDCS and tUS on Pain Perception in OA of the Knee",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Pain",
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "transcranial direct current stimulation (tDCS)",
          "type": "DEVICE"
        },
        {
          "name": "transcranial ultrasound (TUS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 28,
      "start_date": "2015-03",
      "completion_date": "2016-08",
      "has_results": false,
      "last_update_posted_date": "2020-04-24",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02330315"
    },
    {
      "nct_id": "NCT03625752",
      "title": "Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Neuropathies",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Active Comparator: Active tDCS + Active TUS",
          "type": "DEVICE"
        },
        {
          "name": "Sham",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2019-06-06",
      "completion_date": "2027-05-07",
      "has_results": false,
      "last_update_posted_date": "2026-06-29",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Cleveland, Ohio",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03625752"
    },
    {
      "nct_id": "NCT03519737",
      "title": "Aureva Transcranial Ultrasound Device With tPA in Patients With Acute Ischemic Stroke",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Ischemic Stroke"
      ],
      "interventions": [
        {
          "name": "tPA in combination with the Sonolysis Headframe (TUS)",
          "type": "DEVICE"
        },
        {
          "name": "tPA in combination with the Sonolysis Headframe (Sham TUS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cerevast Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 596,
      "start_date": "2018-08-17",
      "completion_date": "2021-12-31",
      "has_results": false,
      "last_update_posted_date": "2018-11-30",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 2,
      "location_summary": "Memphis, Tennessee • Houston, Texas",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03519737"
    },
    {
      "nct_id": "NCT04206215",
      "title": "Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Pain",
        "Carpal Tunnel Syndrome"
      ],
      "interventions": [
        {
          "name": "transcranial Direct Current Stimulation (tDCS)",
          "type": "DEVICE"
        },
        {
          "name": "Transcranial Ultrasound (TUS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 95,
      "start_date": "2021-04-16",
      "completion_date": "2027-12-28",
      "has_results": false,
      "last_update_posted_date": "2026-08-18",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04206215"
    },
    {
      "nct_id": "NCT07099092",
      "title": "Causal Mechanisms of Odor-Guided Behavior in Humans",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Normal Physiology"
      ],
      "interventions": [
        {
          "name": "TUS PirC",
          "type": "DEVICE"
        },
        {
          "name": "TUS Amy",
          "type": "DEVICE"
        },
        {
          "name": "TUS Sham",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 80,
      "start_date": "2026-09-09",
      "completion_date": "2035-07-14",
      "has_results": false,
      "last_update_posted_date": "2026-09-04",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07099092"
    },
    {
      "nct_id": "NCT02954432",
      "title": "Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [],
      "conditions": [
        "Chronic Pain",
        "Chronic Low Back Pain"
      ],
      "interventions": [
        {
          "name": "transcranial Direct Current Stimulation (tDCS)",
          "type": "DEVICE"
        },
        {
          "name": "Transcranial Ultrasound (TUS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 40,
      "start_date": "2016-11",
      "completion_date": "2026-09",
      "has_results": true,
      "last_update_posted_date": "2025-09-29",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02954432"
    },
    {
      "nct_id": "NCT03981055",
      "title": "Parkinson's Disease: Enhancing Physical Therapy With Brain Stimulation for Treating Postural Instability.",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson Disease"
      ],
      "interventions": [
        {
          "name": "Active Comparator: Active tDCS and Active TUS",
          "type": "DEVICE"
        },
        {
          "name": "Sham Comparator: Sham TDCS and Sham TUS",
          "type": "DEVICE"
        },
        {
          "name": "Physical Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "40 Years to 90 Years"
      },
      "enrollment_count": 40,
      "start_date": "2020-01-23",
      "completion_date": "2026-10-30",
      "has_results": true,
      "last_update_posted_date": "2026-03-03",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03981055"
    },
    {
      "nct_id": "NCT02723929",
      "title": "Effects of tDCS and tUS on Pain Perception in OA of the Knee",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [],
      "conditions": [
        "Chronic Pain",
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "active low-intensity transcranial electrical stimulation/active transcranial ultrasound",
          "type": "DEVICE"
        },
        {
          "name": "Sham low-intensity transcranial electrical stimulation/sham transcranial ultrasound",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 64,
      "start_date": "2016-09",
      "completion_date": "2026-12-07",
      "has_results": true,
      "last_update_posted_date": "2025-09-29",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02723929"
    },
    {
      "nct_id": "NCT04379115",
      "title": "Optimization of NIBS for Treatment of Addiction",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-use Disorder",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Active Comparator: Active tDCS + Active TUS",
          "type": "DEVICE"
        },
        {
          "name": "Sham Comparator: Sham tDCS + Sham TUS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 126,
      "start_date": "2021-04-04",
      "completion_date": "2027-10-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-04",
      "last_synced_at": "2026-09-05T03:37:25.916Z",
      "location_count": 3,
      "location_summary": "Hinsdale, Illinois • Cambridge, Massachusetts • Cleveland, Ohio",
      "locations": [
        {
          "city": "Hinsdale",
          "state": "Illinois"
        },
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04379115"
    }
  ]
}