{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=TYRX+Envelope",
    "query": {
      "intervention": "TYRX Envelope"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-07T03:38:15.446Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02277990",
      "title": "World-wide Randomized Antibiotic Envelope Infection Prevention Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "CIED Related Infection"
      ],
      "interventions": [
        {
          "name": "TYRX™ Absorbable Antibacterial Envelope",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Cardiac Rhythm and Heart Failure",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7075,
      "start_date": "2015-01",
      "completion_date": "2018-09",
      "has_results": true,
      "last_update_posted_date": "2019-11-05",
      "last_synced_at": "2026-09-07T03:38:15.446Z",
      "location_count": 120,
      "location_summary": "Anchorage, Alaska • Mesa, Arizona • Scottsdale, Arizona + 94 more",
      "locations": [
        {
          "city": "Anchorage",
          "state": "Alaska"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Chula Vista",
          "state": "California"
        },
        {
          "city": "Fresno",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02277990"
    },
    {
      "nct_id": "NCT01043705",
      "title": "TYRX™ Envelope for Prevention of Infection Following Replacement With a CRT or ICD",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiac Implantable Electronic Device Infection"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "TYRX, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1262,
      "start_date": "2010-01",
      "completion_date": "2015-05",
      "has_results": true,
      "last_update_posted_date": "2015-12-24",
      "last_synced_at": "2026-09-07T03:38:15.446Z",
      "location_count": 52,
      "location_summary": "Birmingham, Alabama • Decatur, Alabama • Florence, Alabama + 44 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Decatur",
          "state": "Alabama"
        },
        {
          "city": "Florence",
          "state": "Alabama"
        },
        {
          "city": "Gadsden",
          "state": "Alabama"
        },
        {
          "city": "Scottsdate",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01043705"
    },
    {
      "nct_id": "NCT05356546",
      "title": "TYRX™ Pocket Health Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiac Disease",
        "Healing Surgical Wounds"
      ],
      "interventions": [
        {
          "name": "Study-required procedures include: tissue collection from device capsule, questionnaire collection, and photo collection",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medtronic Cardiac Rhythm and Heart Failure",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 36,
      "start_date": "2022-05-31",
      "completion_date": "2023-07-06",
      "has_results": false,
      "last_update_posted_date": "2023-08-24",
      "last_synced_at": "2026-09-07T03:38:15.446Z",
      "location_count": 6,
      "location_summary": "Clearwater, Florida • Tallahassee, Florida • Ridgewood, New Jersey + 3 more",
      "locations": [
        {
          "city": "Clearwater",
          "state": "Florida"
        },
        {
          "city": "Tallahassee",
          "state": "Florida"
        },
        {
          "city": "Ridgewood",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Germantown",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05356546"
    },
    {
      "nct_id": "NCT04351269",
      "title": "Retrospective Experience Of CIED Implantation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiac Disease",
        "Heart Failure",
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "CanGaroo Envelope",
          "type": "DEVICE"
        },
        {
          "name": "TYRX Envelope",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Elutia Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 597,
      "start_date": "2020-04-22",
      "completion_date": "2021-06-30",
      "has_results": true,
      "last_update_posted_date": "2023-07-21",
      "last_synced_at": "2026-09-07T03:38:15.446Z",
      "location_count": 1,
      "location_summary": "Athens, Georgia",
      "locations": [
        {
          "city": "Athens",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04351269"
    },
    {
      "nct_id": "NCT04645173",
      "title": "Comparison of Participants Who Received a CanGaroo® Envelope, TYRX™ Envelope, or no Envelope During CIED Implantation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiac Disease"
      ],
      "interventions": [
        {
          "name": "CIED envelope",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Elutia Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2021-02-02",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-01-09",
      "last_synced_at": "2026-09-07T03:38:15.446Z",
      "location_count": 11,
      "location_summary": "Chandler, Arizona • Bay Pines, Florida • Jacksonville, Florida + 7 more",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Bay Pines",
          "state": "Florida"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04645173"
    }
  ]
}