{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Targeted+Temperature+Management&page=4",
    "query": {
      "intervention": "Targeted Temperature Management",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 114,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Targeted+Temperature+Management&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Targeted+Temperature+Management&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-28T15:06:41.093Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05095909",
      "title": "Utility of Intermittent Cryo-Compression Versus Traditional Icing Following Arthroscopic Rotator Cuff Repair",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rotator Cuff Injuries",
        "Cryotherapy Effect"
      ],
      "interventions": [
        {
          "name": "Cryo-compression",
          "type": "DEVICE"
        },
        {
          "name": "Cryo-therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Allina Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 100,
      "start_date": "2024-08-05",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-01-27",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 1,
      "location_summary": "Plymouth, Minnesota",
      "locations": [
        {
          "city": "Plymouth",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05095909"
    },
    {
      "nct_id": "NCT02260869",
      "title": "Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Genicular nerve radiofrequency ablation",
          "type": "PROCEDURE"
        },
        {
          "name": "Pain Management Radiofrequency Kit",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Millennium Pain Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 79,
      "start_date": "2015-01",
      "completion_date": "2019-06-26",
      "has_results": true,
      "last_update_posted_date": "2022-04-26",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 3,
      "location_summary": "Bloomington, Illinois • Decatur, Illinois • Peoria, Illinois",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Illinois"
        },
        {
          "city": "Decatur",
          "state": "Illinois"
        },
        {
          "city": "Peoria",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02260869"
    },
    {
      "nct_id": "NCT04772222",
      "title": "Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Morphine Sulfate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "Up to 24 Hours"
      },
      "enrollment_count": 50,
      "start_date": "2022-06-20",
      "completion_date": "2025-12-31",
      "has_results": true,
      "last_update_posted_date": "2026-03-06",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 5,
      "location_summary": "Murray, Utah • Ogden, Utah • Provo, Utah + 1 more",
      "locations": [
        {
          "city": "Murray",
          "state": "Utah"
        },
        {
          "city": "Ogden",
          "state": "Utah"
        },
        {
          "city": "Provo",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04772222"
    },
    {
      "nct_id": "NCT07874724",
      "title": "Cryoneurolysis for Abdominal Wall Relaxation Prior to Ventral Hernia Repair",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ventral Hernia",
        "Incisional Hernia",
        "Hernia",
        "Hernia Abdominal Wall",
        "Hernia Incisional",
        "Hernia Incisional Ventral",
        "Hernia of Abdominal Wall",
        "Hernia Surgery"
      ],
      "interventions": [
        {
          "name": "Cryoneurolysis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 10,
      "start_date": "2026-11-01",
      "completion_date": "2027-03-01",
      "has_results": false,
      "last_update_posted_date": "2026-10-15",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07874724"
    },
    {
      "nct_id": "NCT04217551",
      "title": "Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiac Arrest, Out-Of-Hospital",
        "Hypothermia, Induced",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1158,
      "start_date": "2020-05-18",
      "completion_date": "2026-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-15",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 76,
      "location_summary": "Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04217551"
    },
    {
      "nct_id": "NCT04094857",
      "title": "Phase 1 Study of HBN-1",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cardiac Arrest"
      ],
      "interventions": [
        {
          "name": "HBN-1",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hibernaid, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 18,
      "start_date": "2019-10-30",
      "completion_date": "2020-12-31",
      "has_results": false,
      "last_update_posted_date": "2019-10-07",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 2,
      "location_summary": "Portland, Maine • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Portland",
          "state": "Maine"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04094857"
    },
    {
      "nct_id": "NCT00469118",
      "title": "Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "DRX9000™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "NEMA Research, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2009-02",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2015-10-12",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00469118"
    },
    {
      "nct_id": "NCT02991690",
      "title": "Systemic Hypothermia in Acute Cervical Spinal Cord Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injury, Acute"
      ],
      "interventions": [
        {
          "name": "Alsius Icy CoolGuard® Catheter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 120,
      "start_date": "2017-08-04",
      "completion_date": "2027-09-29",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 7,
      "location_summary": "Phoenix, Arizona • Miami, Florida • Atlanta, Georgia + 4 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02991690"
    },
    {
      "nct_id": "NCT01471015",
      "title": "Darbe Administration in Newborns Undergoing Cooling for Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Darbepoetin alfa",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "Up to 24 Hours"
      },
      "enrollment_count": 30,
      "start_date": "2012-09",
      "completion_date": "2014-01",
      "has_results": true,
      "last_update_posted_date": "2024-07-23",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 7,
      "location_summary": "Albuquerque, New Mexico • Nashville, Tennessee • Ogden, Utah + 3 more",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Ogden",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01471015"
    },
    {
      "nct_id": "NCT04621279",
      "title": "Cool Prime Comparative Effectiveness Study for Mild HIE",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Hypoxic Ischemic Encephalopathy of Newborn"
      ],
      "interventions": [
        {
          "name": "Normothermia",
          "type": "PROCEDURE"
        },
        {
          "name": "Whole body therapeutic hypothermia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "36 Weeks",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "36 Weeks and older"
      },
      "enrollment_count": 460,
      "start_date": "2023-07-19",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-09-25",
      "last_synced_at": "2026-10-28T15:06:41.093Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04621279"
    }
  ]
}