{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=The+second+booster+vaccine+phase%3A", "query": { "intervention": "The second booster vaccine phase:" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 22, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=The+second+booster+vaccine+phase%3A&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T08:23:08.532Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05541861", "title": "Safety and Effects of an Investigational COVID-19 Vaccine as Booster in Healthy People", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "SARS-CoV-2 Infection", "COVID-19" ], "interventions": [ { "name": "BNT162b2 Bivalent (original/Omicron BA.4/BA.5) 30 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 5 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 10 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 15 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 30 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b2 Monovalent (OMI XBB.1.5) 30 mcg", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "BioNTech SE", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 383, "start_date": "2022-11-08", "completion_date": "2024-11-22", "has_results": true, "last_update_posted_date": "2026-01-13", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 17, "location_summary": "Tempe, Arizona • Newport Beach, California • San Diego, California + 13 more", "locations": [ { "city": "Tempe", "state": "Arizona" }, { "city": "Newport Beach", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Milford", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT05541861" }, { "nct_id": "NCT04927065", "title": "A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19) Variants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "SARS-CoV-2" ], "interventions": [ { "name": "mRNA-1273.211", "type": "BIOLOGICAL" }, { "name": "mRNA-1273", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.617.2", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.213", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.529", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.214", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.222", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.815", "type": "BIOLOGICAL" }, { "name": "mRNA-1273.231", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "ModernaTX, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 5161, "start_date": "2021-05-28", "completion_date": "2023-11-17", "has_results": true, "last_update_posted_date": "2025-02-28", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 23, "location_summary": "Sacramento, California • Hollywood, Florida • Jacksonville, Florida + 18 more", "locations": [ { "city": "Sacramento", "state": "California" }, { "city": "Hollywood", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Savannah", "state": "Georgia" }, { "city": "Sioux City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT04927065" }, { "nct_id": "NCT05875701", "title": "Phase 3 Study of Novavax Vaccine(s) as Booster Dose After mRNA Vaccines", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "NVX-CoV2373", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 rS antigen/Matrix-M Adjuvant", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Novavax", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "49 Years", "sex": "ALL", "summary": "18 Years to 49 Years" }, "enrollment_count": 147, "start_date": "2023-03-28", "completion_date": "2023-11-11", "has_results": true, "last_update_posted_date": "2025-06-26", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 5, "location_summary": "Austin, Texas • Fort Worth, Texas • Plano, Texas + 1 more", "locations": [ { "city": "Austin", "state": "Texas" }, { "city": "Austin", "state": "Texas" }, { "city": "Fort Worth", "state": "Texas" }, { "city": "Plano", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05875701" }, { "nct_id": "NCT00766753", "title": "Vaccination-Dendritic Cells With Peptides for Recurrent Malignant Gliomas", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Malignant Glioma" ], "interventions": [ { "name": "Dendritic vaccine pulsed with multiple peptides", "type": "BIOLOGICAL" }, { "name": "The first booster vaccine phase:", "type": "BIOLOGICAL" }, { "name": "The second booster vaccine phase:", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Frank Lieberman", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 22, "start_date": "2006-12", "completion_date": "2016-06", "has_results": true, "last_update_posted_date": "2018-02-07", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00766753" }, { "nct_id": "NCT04611802", "title": "A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "SARS-CoV Infection", "Covid19" ], "interventions": [ { "name": "SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period)", "type": "BIOLOGICAL" }, { "name": "Placebo (Initial Vaccination Period)", "type": "OTHER" }, { "name": "SARS-CoV-2 rS/Matrix-M1 Adjuvant (Crossover Vaccination period)", "type": "BIOLOGICAL" }, { "name": "Placebo (Crossover Vaccination period)", "type": "OTHER" }, { "name": "SARS-CoV-2 rS/Matrix-M1 Adjuvant (Booster Vaccination)", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 rS/Matrix-M1 Adjuvant (Second Booster Vaccination)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Novavax", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 33000, "start_date": "2020-12-27", "completion_date": "2023-12-15", "has_results": false, "last_update_posted_date": "2023-12-21", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 144, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Tempe, Arizona + 110 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT04611802" }, { "nct_id": "NCT00350337", "title": "Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dengue" ], "interventions": [ { "name": "Pre-transfection F17", "type": "BIOLOGICAL" }, { "name": "Post-transfection F17", "type": "BIOLOGICAL" }, { "name": "Post-transfection F19", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 86, "start_date": "2006-04-05", "completion_date": "2008-03-13", "has_results": true, "last_update_posted_date": "2021-02-12", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00350337" }, { "nct_id": "NCT04528719", "title": "A Dose Escalation Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1345 in Healthy Adults and in Children Who Are Respiratory Syncytial Virus (RSV)-Seropositive", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Respiratory Syncytial Virus" ], "interventions": [ { "name": "mRNA-1345", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "ModernaTX, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Months", "maximum_age": "79 Years", "sex": "ALL", "summary": "12 Months to 79 Years" }, "enrollment_count": 651, "start_date": "2020-09-30", "completion_date": "2024-07-18", "has_results": false, "last_update_posted_date": "2024-08-07", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 31, "location_summary": "La Mesa, California • West Hollywood, California • DeLand, Florida + 28 more", "locations": [ { "city": "La Mesa", "state": "California" }, { "city": "West Hollywood", "state": "California" }, { "city": "DeLand", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "West Palm Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04528719" }, { "nct_id": "NCT05975060", "title": "A Study to Evaluate the Safety and Immunogenicity of an (Omicron Subvariant) COVID-19 Vaccine Booster Dose in Previously Vaccinated Participants and Unvaccinated Participants.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "XBB.1.5 Vaccine (Booster)", "type": "BIOLOGICAL" }, { "name": "XBB.1.5 Vaccine (single dose)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Novavax", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "54 Years", "sex": "ALL", "summary": "18 Years to 54 Years" }, "enrollment_count": 660, "start_date": "2023-09-07", "completion_date": "2024-05-20", "has_results": false, "last_update_posted_date": "2024-05-30", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 30, "location_summary": "Mobile, Alabama • Sacramento, California • Colorado Springs, Colorado + 26 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Sacramento", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Coral Gables", "state": "Florida" }, { "city": "Fort Myers", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05975060" }, { "nct_id": "NCT02873286", "title": "RSV-MVA-BN Vaccine Phase II Trial in ≥ 55 Year Old Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Respiratory Syncytial Virus Infections" ], "interventions": [ { "name": "MVA-BN-RSV", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Bavarian Nordic", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "55 Years", "maximum_age": null, "sex": "ALL", "summary": "55 Years and older" }, "enrollment_count": 420, "start_date": "2016-09", "completion_date": "2018-12", "has_results": true, "last_update_posted_date": "2020-09-22", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 12, "location_summary": "Redding, California • San Diego, California • The Villages, Florida + 9 more", "locations": [ { "city": "Redding", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "The Villages", "state": "Florida" }, { "city": "Savannah", "state": "Georgia" }, { "city": "Stockbridge", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02873286" }, { "nct_id": "NCT02654509", "title": "Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Eastern Equine Encephalitis" ], "interventions": [ { "name": "Eastern Equine Encephalitis Vaccine, Inactivated, Dried, TSI-GSD 104", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 138, "start_date": "2008-06-03", "completion_date": "2018-03-18", "has_results": false, "last_update_posted_date": "2020-03-17", "last_synced_at": "2026-09-30T08:23:08.532Z", "location_count": 1, "location_summary": "Fort Deterick, Maryland", "locations": [ { "city": "Fort Deterick", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02654509" } ] }