{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Thermal+pain+thresholds&page=2",
    "query": {
      "intervention": "Thermal pain thresholds",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 25,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Thermal+pain+thresholds&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Thermal+pain+thresholds&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-02T01:37:21.719Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04249596",
      "title": "Tianeptine for Treatment Resistant Depression",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Treatment Resistant Depression"
      ],
      "interventions": [
        {
          "name": "Tianeptine Sodium",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Jonathan A. Javitch, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "21 Years to 60 Years"
      },
      "enrollment_count": 38,
      "start_date": "2020-10-14",
      "completion_date": "2024-08-27",
      "has_results": true,
      "last_update_posted_date": "2026-01-23",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 3,
      "location_summary": "Stanford, California • New York, New York",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04249596"
    },
    {
      "nct_id": "NCT05836649",
      "title": "Impact of Passive VR Versus Active VR on Heat Pain Thresholds and Pressure Pain Thresholds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Oculus Go headset without active intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Oculus Go headset with active intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Oculus Go headset without immersive virtual reality experience",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Oculus Go headset with immersive virtual reality experience",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 265,
      "start_date": "2023-08-04",
      "completion_date": "2024-01-03",
      "has_results": false,
      "last_update_posted_date": "2026-01-15",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05836649"
    },
    {
      "nct_id": "NCT05295225",
      "title": "Green Light Exposure in Healthy Volunteers Exposure in Normal Human Volunteers",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Green Light Emitting Diode",
          "type": "DEVICE"
        },
        {
          "name": "White Light Emitting Diode",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Arizona",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 30,
      "start_date": "2022-06-14",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-05",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Tucson, Arizona",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05295225"
    },
    {
      "nct_id": "NCT02345629",
      "title": "Cordotomy for Refractory Cancer Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Advanced Cancers",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Cordotomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Pain/Symptom Questionnaire",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Sharpness Sensory Testing",
          "type": "PROCEDURE"
        },
        {
          "name": "Heat Pain Sensory Testing",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2015-03-10",
      "completion_date": "2020-02-25",
      "has_results": false,
      "last_update_posted_date": "2023-06-07",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02345629"
    },
    {
      "nct_id": "NCT04030442",
      "title": "Cannabidiol, Morphine, Pain",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "CBD",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Immediate-release Oral Morphine Sulfate Tablets",
          "type": "DRUG"
        },
        {
          "name": "Thermal and Pressure Nociceptive Sensitivity",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Wayne State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 40,
      "start_date": "2019-05-01",
      "completion_date": "2025-01-26",
      "has_results": false,
      "last_update_posted_date": "2024-02-29",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04030442"
    },
    {
      "nct_id": "NCT06785129",
      "title": "Endometriosis and Migraine",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Migraine",
        "Endometriosis"
      ],
      "interventions": [
        {
          "name": "Thermal stimuli",
          "type": "DEVICE"
        },
        {
          "name": "Pressure stimuli",
          "type": "DEVICE"
        },
        {
          "name": "Pain ratings",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Conditioned pain modulation (CPM) response",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Hormonal assessment",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL",
        "BIOLOGICAL"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 45 Years · Female only"
      },
      "enrollment_count": 120,
      "start_date": "2025-02-12",
      "completion_date": "2030-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06785129"
    },
    {
      "nct_id": "NCT02751346",
      "title": "Persistent Pain After Cystectomy for Bladder Cancer",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pain",
        "Surgery",
        "Post Operative Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 383,
      "start_date": "2016-01",
      "completion_date": "2017-02",
      "has_results": false,
      "last_update_posted_date": "2018-10-04",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02751346"
    },
    {
      "nct_id": "NCT03283072",
      "title": "Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sensitivity"
      ],
      "interventions": [
        {
          "name": "Intervention 1",
          "type": "DEVICE"
        },
        {
          "name": "Intervention 2",
          "type": "DEVICE"
        },
        {
          "name": "Intervention 3",
          "type": "DEVICE"
        },
        {
          "name": "Intervention 4 (sham)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 22,
      "start_date": "2017-09-18",
      "completion_date": "2020-07-06",
      "has_results": true,
      "last_update_posted_date": "2023-08-21",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03283072"
    },
    {
      "nct_id": "NCT05738213",
      "title": "Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Migraine"
      ],
      "interventions": [
        {
          "name": "Thermal stimuli",
          "type": "DEVICE"
        },
        {
          "name": "Pressure stimuli",
          "type": "DEVICE"
        },
        {
          "name": "Pain ratings",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pressure pain thresholds (PPT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Conditioned pain modulation (CPM) response",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PedMIDAS (Pediatric Migraine Disability Assessment)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Hormonal assessment",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Pubertal status",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL",
        "DIAGNOSTIC_TEST",
        "OTHER"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "11 Years to 15 Years"
      },
      "enrollment_count": 100,
      "start_date": "2023-01-10",
      "completion_date": "2028-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05738213"
    },
    {
      "nct_id": "NCT01588197",
      "title": "Real-Time fMRI Feedback Effects on Pain Perception",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Pain Control"
      ],
      "interventions": [
        {
          "name": "Attention/Distraction Strategy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stimulus Quality/Severity Strategy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control Strategy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 20,
      "start_date": "2010-11",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2019-06-14",
      "last_synced_at": "2026-10-02T01:37:21.719Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01588197"
    }
  ]
}