{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Timolol+Maleate+Ophthalmic+Solution+0.5%25+BID", "query": { "intervention": "Timolol Maleate Ophthalmic Solution 0.5% BID" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 36, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Timolol+Maleate+Ophthalmic+Solution+0.5%25+BID&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-01T09:18:01.763Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01915940", "title": "Bimatoprost Ocular Insert Compared to Topical Timolol Solution in Patients With Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Primary Open-Angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "Bimatoprost", "type": "DRUG" }, { "name": "Timolol 0.5%", "type": "DRUG" }, { "name": "Placebo Eye Drops", "type": "DRUG" }, { "name": "Placebo Ocular Insert", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "ForSight Vision5, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 169, "start_date": "2013-10-23", "completion_date": "2014-11-14", "has_results": true, "last_update_posted_date": "2018-04-20", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 10, "location_summary": "Artesia, California • La Jolla, California • Newport Beach, California + 7 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01915940" }, { "nct_id": "NCT05913232", "title": "Study of Safety and Efficacy of H-1337 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glaucoma Open-Angle Primary", "Ocular Hypertension" ], "interventions": [ { "name": "H-1337 0.6%", "type": "DRUG" }, { "name": "H-1337 1.0%", "type": "DRUG" }, { "name": "H-1337 Placebo", "type": "DRUG" }, { "name": "Timolol 0.5%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "D. Western Therapeutics Institute, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 201, "start_date": "2023-08-28", "completion_date": "2024-08-29", "has_results": true, "last_update_posted_date": "2025-08-27", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 9, "location_summary": "Glendale, California • Colorado Springs, Colorado • Lakeland, Florida + 6 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Lakeland", "state": "Florida" }, { "city": "Largo", "state": "Florida" }, { "city": "Albany", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05913232" }, { "nct_id": "NCT07218796", "title": "Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Cataract", "Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "Bimatoprost Implant System", "type": "DRUG" }, { "name": "SpyGlass IOL", "type": "DEVICE" }, { "name": "Timolol Maleate Ophthalmic Solution, 0.5%", "type": "DRUG" }, { "name": "Commercial IOL", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "SpyGlass Pharma, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": null, "sex": "ALL", "summary": "22 Years and older" }, "enrollment_count": 400, "start_date": "2025-10-28", "completion_date": "2031-05-31", "has_results": false, "last_update_posted_date": "2025-10-20", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07218796" }, { "nct_id": "NCT02250612", "title": "SYL040012, Treatment for Open Angle Glaucoma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Open Angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "1 drop of 0.375% SYL040012 (bamosiran)", "type": "DRUG" }, { "name": "1 drop of 0.750% SYL040012 (bamosiran)", "type": "DRUG" }, { "name": "1 drop of 1.125% SYL040012 (bamosiran)", "type": "DRUG" }, { "name": "1 drop of 1.5% SYL040012 (bamosiran)", "type": "DRUG" }, { "name": "1 drop of 0.5 % timolol maleate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sylentis, S.A.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 184, "start_date": "2014-10", "completion_date": "2016-01", "has_results": true, "last_update_posted_date": "2021-01-06", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 4, "location_summary": "Artesia, California • Petaluma, California • Morrow, Georgia + 1 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Petaluma", "state": "California" }, { "city": "Morrow", "state": "Georgia" }, { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT02250612" }, { "nct_id": "NCT00651612", "title": "Study to Evaluate Safety of Brimonidine/Timolol Fixed Combination in Glaucoma or Ocular Hypertension Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "Brimonidine 0.2%/Timolol 0.5% Fixed Combination Ophthalmic Solution", "type": "DRUG" }, { "name": "Concurrent brimonidine 0.2% and 0.5% timolol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allergan", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 604, "start_date": "2005-11", "completion_date": "2007-01", "has_results": false, "last_update_posted_date": "2008-04-03", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "Newport Beach, California", "locations": [ { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00651612" }, { "nct_id": "NCT01707381", "title": "BOL-303259-X With Timolol 0.5% in Subjects With Open-Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Ocular Hypertension", "Open Angle Glaucoma" ], "interventions": [ { "name": "BOL-303259-X", "type": "DRUG" }, { "name": "Timolol maleate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bausch & Lomb Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "40 Years to 90 Years" }, "enrollment_count": 25, "start_date": "2012-11", "completion_date": "2014-02", "has_results": true, "last_update_posted_date": "2018-09-04", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "La Jolla, California", "locations": [ { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01707381" }, { "nct_id": "NCT00823043", "title": "A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Open-angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "timolol hemihydrate", "type": "DRUG" }, { "name": "timolol maleate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vistakon Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 103, "start_date": "2009-01", "completion_date": "2009-07", "has_results": true, "last_update_posted_date": "2015-03-06", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "San Diego, California", "locations": [ { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00823043" }, { "nct_id": "NCT06152861", "title": "Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Open Angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "Travoprost Ophthalmic Topical Cream low-dose", "type": "DRUG" }, { "name": "Travoprost Ophthalmic Topical Cream mid-dose", "type": "DRUG" }, { "name": "Travoprost Ophthalmic Topical Cream high-dose", "type": "DRUG" }, { "name": "Timolol maleate ophthalmic solution, 0.5%", "type": "DRUG" }, { "name": "Travoprost Ophthalmic Solution, 0.004%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Glaukos Corporation", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 250, "start_date": "2023-11-15", "completion_date": "2024-08", "has_results": false, "last_update_posted_date": "2023-12-06", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "Newport Beach, California", "locations": [ { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06152861" }, { "nct_id": "NCT02312544", "title": "Phase 2b Study Evaluating Safety and Efficacy of OTX-TP Compared to Timolol Drops in the Treatment of Subjects With Open Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "OTX-TP", "type": "DRUG" }, { "name": "Timolol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ocular Therapeutix, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 72, "start_date": "2014-11", "completion_date": "2015-12", "has_results": false, "last_update_posted_date": "2016-12-14", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 1, "location_summary": "Fayetteville, Arkansas", "locations": [ { "city": "Fayetteville", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02312544" }, { "nct_id": "NCT07168902", "title": "Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glaucoma" ], "interventions": [ { "name": "BL1107 Low dose", "type": "DRUG" }, { "name": "BL1107 High dose", "type": "DRUG" }, { "name": "Timolol maleate 0.5%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bausch & Lomb Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 252, "start_date": "2025-10-24", "completion_date": "2026-05-18", "has_results": false, "last_update_posted_date": "2026-07-22", "last_synced_at": "2026-10-01T09:18:01.763Z", "location_count": 14, "location_summary": "Glendale, California • Newport Beach, California • Pasadena, California + 11 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "Fort Myers", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07168902" } ] }