{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Tissue+Selective+Estrogen+Complex",
    "query": {
      "intervention": "Tissue Selective Estrogen Complex"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T16:18:03.935Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03740009",
      "title": "Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause\"",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Perimenopausal Disorder",
        "Depression"
      ],
      "interventions": [
        {
          "name": "Bazedoxifene/Conjugated Estrogen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "44 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "44 Years to 55 Years · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2019-01-02",
      "completion_date": "2021-05-17",
      "has_results": true,
      "last_update_posted_date": "2022-05-10",
      "last_synced_at": "2026-09-11T16:18:03.935Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03740009"
    },
    {
      "nct_id": "NCT02694809",
      "title": "The PROMISE Study: Duavee in Women With DCIS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ductal Breast Carcinoma In Situ",
        "Postmenopausal"
      ],
      "interventions": [
        {
          "name": "Conjugated Estrogens/Bazedoxifene",
          "type": "DRUG"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        },
        {
          "name": "Pharmacological Study",
          "type": "OTHER"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "PROCEDURE"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "79 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 79 Years · Female only"
      },
      "enrollment_count": 142,
      "start_date": "2017-01",
      "completion_date": "2024-06-19",
      "has_results": false,
      "last_update_posted_date": "2025-01-28",
      "last_synced_at": "2026-09-11T16:18:03.935Z",
      "location_count": 10,
      "location_summary": "Aurora, Colorado • Chicago, Illinois • Geneva, Illinois + 7 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Geneva",
          "state": "Illinois"
        },
        {
          "city": "Lake Forest",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02694809"
    },
    {
      "nct_id": "NCT04103476",
      "title": "Advancing Postmenopausal Preventive Therapy",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Atherosclerosis",
        "Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "59 Years",
        "sex": "FEMALE",
        "summary": "45 Years to 59 Years · Female only"
      },
      "enrollment_count": 385,
      "start_date": "2021-04-13",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-12-05",
      "last_synced_at": "2026-09-11T16:18:03.935Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04103476"
    },
    {
      "nct_id": "NCT02710214",
      "title": "A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Menopause",
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "Tissue Selective Estrogen Complex",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "62 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 62 Years · Female only"
      },
      "enrollment_count": 24,
      "start_date": "2016-02",
      "completion_date": "2019-04-24",
      "has_results": true,
      "last_update_posted_date": "2020-07-15",
      "last_synced_at": "2026-09-11T16:18:03.935Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02710214"
    },
    {
      "nct_id": "NCT02274571",
      "title": "Raising Insulin Sensitivity in Post Menopause",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Menopause"
      ],
      "interventions": [
        {
          "name": "TSEC (Tissue-selective estrogen complexes)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Pennington Biomedical Research Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "50 Years to 60 Years · Female only"
      },
      "enrollment_count": 8,
      "start_date": "2015-09",
      "completion_date": "2017-04-11",
      "has_results": true,
      "last_update_posted_date": "2025-06-04",
      "last_synced_at": "2026-09-11T16:18:03.935Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02274571"
    }
  ]
}