{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Tofacitinib+with+methotrexate", "query": { "intervention": "Tofacitinib with methotrexate" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 17, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Tofacitinib+with+methotrexate&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-25T23:46:38.660Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02831855", "title": "Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "CP-690,550", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 694, "start_date": "2016-09-01", "completion_date": "2018-12-17", "has_results": true, "last_update_posted_date": "2019-12-04", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 59, "location_summary": "Huntsville, Alabama • Gilbert, Arizona • Peoria, Arizona + 48 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Fair Oaks", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02831855" }, { "nct_id": "NCT01164579", "title": "Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Tasocitinib plus Methotrexate", "type": "DRUG" }, { "name": "Tofacitinib plus placebo methotrexate", "type": "DRUG" }, { "name": "Placebo tofacitinib plus Methotrexate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 109, "start_date": "2010-10", "completion_date": "2013-11", "has_results": true, "last_update_posted_date": "2015-04-22", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 8, "location_summary": "Gilbert, Arizona • Huntington Beach, California • Upland, California + 5 more", "locations": [ { "city": "Gilbert", "state": "Arizona" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Upland", "state": "California" }, { "city": "Ormond Beach", "state": "Florida" }, { "city": "Pinellas Park", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01164579" }, { "nct_id": "NCT01745055", "title": "Co-Administration Of Methotrexate And CP-690,550", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "CP-690,550 (tofacitinib)", "type": "DRUG" }, { "name": "Methotrexate (MTX)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 12, "start_date": "2005-04", "completion_date": "2006-06", "has_results": true, "last_update_posted_date": "2013-02-04", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 4, "location_summary": "Daytona Beach, Florida • Fort Lauderdale, Florida • Miramar, Florida + 1 more", "locations": [ { "city": "Daytona Beach", "state": "Florida" }, { "city": "Fort Lauderdale", "state": "Florida" }, { "city": "Miramar", "state": "Florida" }, { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01745055" }, { "nct_id": "NCT02147587", "title": "A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Tofacitinib", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 112, "start_date": "2014-06", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2018-04-11", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 36, "location_summary": "Jonesboro, Arkansas • Los Angeles, California • Santa Maria, California + 26 more", "locations": [ { "city": "Jonesboro", "state": "Arkansas" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Santa Maria", "state": "California" }, { "city": "Upland", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02147587" }, { "nct_id": "NCT04259138", "title": "Determination of the Optimal Treatment Target in Ulcerative Colitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Colitis, Ulcerative" ], "interventions": [ { "name": "Treatment Algorithm A", "type": "BIOLOGICAL" }, { "name": "Treatment Algorithm B", "type": "BIOLOGICAL" }, { "name": "Treatment Algorithm C", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Alimentiv Inc.", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 672, "start_date": "2020-02-18", "completion_date": "2026-04-13", "has_results": false, "last_update_posted_date": "2026-09-10", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 5, "location_summary": "Ypsilanti, Michigan • New York, New York • Asheville, North Carolina + 1 more", "locations": [ { "city": "Ypsilanti", "state": "Michigan" }, { "city": "New York", "state": "New York" }, { "city": "New York", "state": "New York" }, { "city": "Asheville", "state": "North Carolina" }, { "city": "Charlotte", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT04259138" }, { "nct_id": "NCT01359150", "title": "A Study To Assess the Immune Response Following Administration Of Influenza and Pneumococcal Vaccines To Subjects With Rheumatoid Arthritis Receiving CP-690,550 Or Placebo", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "CP-690,550", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 223, "start_date": "2011-09", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2013-03-29", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 51, "location_summary": "Gilbert, Arizona • Paradise Valley, Arizona • Jonesboro, Arkansas + 45 more", "locations": [ { "city": "Gilbert", "state": "Arizona" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Jonesboro", "state": "Arkansas" }, { "city": "Fair Oaks", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01359150" }, { "nct_id": "NCT03414502", "title": "Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Methotrexate", "type": "DRUG" }, { "name": "Abatacept", "type": "DRUG" }, { "name": "Adalimumab", "type": "DRUG" }, { "name": "Azathioprine", "type": "DRUG" }, { "name": "Baricitinib", "type": "DRUG" }, { "name": "Certolizumab", "type": "DRUG" }, { "name": "Etanercept", "type": "DRUG" }, { "name": "Golimumab", "type": "DRUG" }, { "name": "Hydroxychloroquine", "type": "DRUG" }, { "name": "Infliximab", "type": "DRUG" }, { "name": "Leflunomide", "type": "DRUG" }, { "name": "Minocycline", "type": "DRUG" }, { "name": "Rituximab", "type": "DRUG" }, { "name": "Sarilumab", "type": "DRUG" }, { "name": "Sulfasalazine", "type": "DRUG" }, { "name": "Tofacitinib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Nebraska", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 400, "start_date": "2007-12-10", "completion_date": "2029-03", "has_results": false, "last_update_posted_date": "2026-06-17", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 1, "location_summary": "Omaha, Nebraska", "locations": [ { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT03414502" }, { "nct_id": "NCT00976599", "title": "A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "CP-690,550 + methotrexate", "type": "DRUG" }, { "name": "Placebo + Methotrexate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 29, "start_date": "2009-11", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2013-01-09", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 15, "location_summary": "Birmingham, Alabama • La Jolla, California • Frederick, Maryland + 8 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "La Jolla", "state": "California" }, { "city": "Frederick", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00976599" }, { "nct_id": "NCT01741493", "title": "A Study in Healthy Adults and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Doses of ABT-494", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "ABT-494", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Tofacitinib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie (prior sponsor, Abbott)", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 67, "start_date": "2012-11", "completion_date": "2013-12", "has_results": false, "last_update_posted_date": "2017-11-20", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 5, "location_summary": "Miami, Florida • Cincinnati, Ohio • Duncansville, Pennsylvania + 2 more", "locations": [ { "city": "Miami", "state": "Florida" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Duncansville", "state": "Pennsylvania" }, { "city": "Austin", "state": "Texas" }, { "city": "Orem", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT01741493" }, { "nct_id": "NCT00847613", "title": "A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Arthritis, Rheumatoid" ], "interventions": [ { "name": "CP-690,550", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 800, "start_date": "2009-03", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2024-05-16", "last_synced_at": "2026-09-25T23:46:38.660Z", "location_count": 37, "location_summary": "Huntsville, Alabama • Tucson, Arizona • San Diego, California + 32 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Maria", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00847613" } ] }