{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothbrushing&page=4",
    "query": {
      "intervention": "Toothbrushing",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 208,
    "total_pages": 21,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothbrushing&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothbrushing&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-26T00:52:49.041Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04197427",
      "title": "Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Experimental Oral Rinse",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "You First Services",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 62,
      "start_date": "2020-03-01",
      "completion_date": "2020-12-31",
      "has_results": false,
      "last_update_posted_date": "2019-12-17",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04197427"
    },
    {
      "nct_id": "NCT06479096",
      "title": "Four-Week Oral Malodor and Clinical Safety for a Concentrated Cosmetic Mouthwash",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oral Malodor"
      ],
      "interventions": [
        {
          "name": "Brush / Espresso Mild Prototype",
          "type": "OTHER"
        },
        {
          "name": "Brush / Espresso Intense Prototype",
          "type": "OTHER"
        },
        {
          "name": "Brush / Fresh Breath Oral Rinse",
          "type": "OTHER"
        },
        {
          "name": "Brush / Hydroalcohol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 166,
      "start_date": "2024-07-15",
      "completion_date": "2024-09-12",
      "has_results": false,
      "last_update_posted_date": "2025-01-08",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06479096"
    },
    {
      "nct_id": "NCT05756673",
      "title": "A Study of Virtually Supervised Mouthwash and Interdental Brushes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Colgate Cavity Protection Toothpaste",
          "type": "DRUG"
        },
        {
          "name": "LISTERINE ZERO Alcohol Mouthwash COOL MINT",
          "type": "DRUG"
        },
        {
          "name": "LISTERINE COOL MINT Antiseptic Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "TePe Original Interdental Brush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 292,
      "start_date": "2023-02-09",
      "completion_date": "2023-10-03",
      "has_results": false,
      "last_update_posted_date": "2023-10-17",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05756673"
    },
    {
      "nct_id": "NCT06354270",
      "title": "A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dentin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Regular fluoride toothpaste (Crest Cavity Protection)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 115,
      "start_date": "2024-04-11",
      "completion_date": "2024-06-23",
      "has_results": true,
      "last_update_posted_date": "2025-06-25",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06354270"
    },
    {
      "nct_id": "NCT06193512",
      "title": "Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oral Bacterial Infection",
        "Mechanical Ventilation Complication"
      ],
      "interventions": [
        {
          "name": "SwishKit + Oral care treatment as usual",
          "type": "DEVICE"
        },
        {
          "name": "Oral care treatment as usual",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2024-03-08",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-30",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06193512"
    },
    {
      "nct_id": "NCT07829328",
      "title": "Can SAP P11-4 Affect The Appearance of Interproximal Cavities on an X-ray in a Military Population",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Incipient Interproximal Caries"
      ],
      "interventions": [
        {
          "name": "0.05% Sodium Fluoride with Self-Assembling Peptides",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tripler Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "18 Years to 74 Years"
      },
      "enrollment_count": 30,
      "start_date": "2026-09-30",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-09-21",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Schofield Barracks, Hawaii",
      "locations": [
        {
          "city": "Schofield Barracks",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07829328"
    },
    {
      "nct_id": "NCT06352645",
      "title": "Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Plaque Induced Gingivitis"
      ],
      "interventions": [
        {
          "name": "Bixdo Ultra Compact Water Flosser",
          "type": "DEVICE"
        },
        {
          "name": "Manual toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Tufts University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 165,
      "start_date": "2025-03-04",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06352645"
    },
    {
      "nct_id": "NCT06300866",
      "title": "Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Gingivitis",
        "Plaque, Dental"
      ],
      "interventions": [
        {
          "name": "Test",
          "type": "DRUG"
        },
        {
          "name": "Control",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 80,
      "start_date": "2020-08-18",
      "completion_date": "2021-03-08",
      "has_results": false,
      "last_update_posted_date": "2024-03-08",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06300866"
    },
    {
      "nct_id": "NCT00224185",
      "title": "Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Smoking",
        "Lung Diseases"
      ],
      "interventions": [
        {
          "name": "Bronchopulmonary Lung Lavage",
          "type": "PROCEDURE"
        },
        {
          "name": "Bronchial Brushing",
          "type": "PROCEDURE"
        },
        {
          "name": "Bronchial Wall Biopsy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 196,
      "start_date": "2004-01",
      "completion_date": "2012-09",
      "has_results": false,
      "last_update_posted_date": "2016-05-02",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00224185"
    },
    {
      "nct_id": "NCT00260585",
      "title": "Esophageal Cancer Risk Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Esophageal Cancer",
        "Gastroesophageal Reflux Disease (GERD)",
        "Esophageal Diseases",
        "Hiatal Hernia",
        "Esophageal Achalasia"
      ],
      "interventions": [
        {
          "name": "Survey of client health, personal habits, family history",
          "type": "PROCEDURE"
        },
        {
          "name": "Blood specimen for non-DNA and DNA parts",
          "type": "PROCEDURE"
        },
        {
          "name": "Biopsy of esophageal/stomach tissue, lymph nodes, tumor",
          "type": "PROCEDURE"
        },
        {
          "name": "Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7000,
      "start_date": "1999-06",
      "completion_date": "2050-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-14",
      "last_synced_at": "2026-10-26T00:52:49.041Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00260585"
    }
  ]
}