{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothpaste&page=3",
    "query": {
      "intervention": "Toothpaste",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 230,
    "total_pages": 23,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothpaste&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Toothpaste&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-20T02:01:34.481Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04368533",
      "title": "Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Plaque, Dental",
        "Caries, Dental",
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "Livionex Dental Gel",
          "type": "DRUG"
        },
        {
          "name": "A standard children's toothpaste containing 1500 ppm fluoride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "9 Months",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "9 Months to 12 Years"
      },
      "enrollment_count": 78,
      "start_date": "2019-02-08",
      "completion_date": "2020-08-21",
      "has_results": false,
      "last_update_posted_date": "2024-10-16",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04368533"
    },
    {
      "nct_id": "NCT02409836",
      "title": "A Study to Assess the Ingestion of Dentifrice by Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Individuals"
      ],
      "interventions": [
        {
          "name": "Marketed Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Marketed Flavored Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "2 Years to 12 Years"
      },
      "enrollment_count": 90,
      "start_date": "1993-05",
      "completion_date": "1993-07",
      "has_results": false,
      "last_update_posted_date": "2015-04-07",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02409836"
    },
    {
      "nct_id": "NCT02399163",
      "title": "Evaluation of Oral Hygiene Products in an In Situ Caries Model",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Fluoride free toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Fluoride mouthwash",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 80,
      "start_date": "2015-04",
      "completion_date": "2015-08",
      "has_results": true,
      "last_update_posted_date": "2016-05-12",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02399163"
    },
    {
      "nct_id": "NCT02940821",
      "title": "Assessing the Effects of Three Oral Care Regimens",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Toothbrushing",
          "type": "OTHER"
        },
        {
          "name": "Fluoridated Dentifrice (.15% sodium monofluorophosphate)",
          "type": "OTHER"
        },
        {
          "name": "Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide)",
          "type": "OTHER"
        },
        {
          "name": "Whitening (4.5% hydrogen peroxide)",
          "type": "OTHER"
        },
        {
          "name": "Other Fluoridated Dentifrice (.454% stannous fluoride)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pearl Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 142,
      "start_date": "2016-05-30",
      "completion_date": "2017-07-27",
      "has_results": false,
      "last_update_posted_date": "2017-11-14",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Emerson, New Jersey",
      "locations": [
        {
          "city": "Emerson",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02940821"
    },
    {
      "nct_id": "NCT01059058",
      "title": "Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Demineralization"
      ],
      "interventions": [
        {
          "name": "MI Paste Plus",
          "type": "PROCEDURE"
        },
        {
          "name": "PreviDent Fluoride Varnish",
          "type": "PROCEDURE"
        },
        {
          "name": "Normal Home Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "12 Years to 20 Years"
      },
      "enrollment_count": 240,
      "start_date": "2010-03",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2015-08-17",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01059058"
    },
    {
      "nct_id": "NCT07836998",
      "title": "A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "Whitening Toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Experimental Mouthwash",
          "type": "DEVICE"
        },
        {
          "name": "Regular Fluoride Toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 360,
      "start_date": "2026-09-25",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-10-07",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07836998"
    },
    {
      "nct_id": "NCT07419763",
      "title": "Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Negative Control Toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Active Comparator",
          "type": "DRUG"
        },
        {
          "name": "Test toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Church & Dwight Company, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-04-15",
      "completion_date": "2025-06-10",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Noblesville, Indiana",
      "locations": [
        {
          "city": "Noblesville",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07419763"
    },
    {
      "nct_id": "NCT04221334",
      "title": "Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbrush",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis",
        "Plaque, Dental"
      ],
      "interventions": [
        {
          "name": "Electric Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "oral health care application",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 79,
      "start_date": "2019-04-30",
      "completion_date": "2019-07-27",
      "has_results": false,
      "last_update_posted_date": "2020-01-09",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04221334"
    },
    {
      "nct_id": "NCT00763269",
      "title": "The Efficacy of a Toothpaste to Reduce Sensitivity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dentin Hypersensitivity"
      ],
      "interventions": [
        {
          "name": "Triclosan, Silicon dioxide, fluoride",
          "type": "DRUG"
        },
        {
          "name": "Triclosan, fluoride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "12 Years to 80 Years"
      },
      "enrollment_count": 626,
      "start_date": "2008-09",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2012-03-07",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Cedar Knolls, New Jersey",
      "locations": [
        {
          "city": "Cedar Knolls",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00763269"
    },
    {
      "nct_id": "NCT06798441",
      "title": "Determination of the Oral Irritation Potential of a Fluoride Rinse in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Brush Only",
          "type": "OTHER"
        },
        {
          "name": "Brush / Rinse (Jolly Rancher Prototype)",
          "type": "OTHER"
        },
        {
          "name": "Brush / Rinse (LISTERINE® Total Care Zero Alcohol)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "11 Years",
        "sex": "ALL",
        "summary": "6 Years to 11 Years"
      },
      "enrollment_count": 161,
      "start_date": "2025-01-20",
      "completion_date": "2025-02-20",
      "has_results": false,
      "last_update_posted_date": "2025-03-12",
      "last_synced_at": "2026-10-20T02:01:34.481Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06798441"
    }
  ]
}