{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+Disc+Replacement",
    "query": {
      "intervention": "Total Disc Replacement"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 17,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+Disc+Replacement&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-09T00:11:19.065Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00215332",
      "title": "CHARITE™ vs. ALIF 5-Year Follow-up",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "CHARITE",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DePuy Spine",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 367,
      "start_date": "2005-03",
      "completion_date": "2007-07",
      "has_results": false,
      "last_update_posted_date": "2015-04-13",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 10,
      "location_summary": "Los Angeles, California • Golden, Colorado • Chicago, Illinois + 7 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Golden",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Towson",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00215332"
    },
    {
      "nct_id": "NCT00927238",
      "title": "XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "XL TDR",
          "type": "DEVICE"
        },
        {
          "name": "Lumbar fusion surgery",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "NuVasive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 246,
      "start_date": "2009-07",
      "completion_date": "2015-07",
      "has_results": false,
      "last_update_posted_date": "2015-07-30",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 17,
      "location_summary": "Campbell, California • Thousand Oaks, California • Durango, Colorado + 14 more",
      "locations": [
        {
          "city": "Campbell",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        },
        {
          "city": "Durango",
          "state": "Colorado"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00927238"
    },
    {
      "nct_id": "NCT04122248",
      "title": "M6-C Post Approval Study (PAS)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cervical Degenerative Disc Disease",
        "Cervical Radiculopathy",
        "Cervical Spinal Cord Compression",
        "Cervical Disc Herniation"
      ],
      "interventions": [
        {
          "name": "standard radiographic imaging",
          "type": "OTHER"
        },
        {
          "name": "cervical total disc replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Spinal Kinetics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "21 Years to 68 Years"
      },
      "enrollment_count": 152,
      "start_date": "2019-11-30",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-07-30",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 21,
      "location_summary": "Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Sun City West",
          "state": "Arizona"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04122248"
    },
    {
      "nct_id": "NCT00374413",
      "title": "Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease (DDD)"
      ],
      "interventions": [
        {
          "name": "Artificial disk",
          "type": "DEVICE"
        },
        {
          "name": "Artificial disc",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "SpinalMotion",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 343,
      "start_date": "2005-07",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2013-09-13",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 21,
      "location_summary": "Beverly Hills, California • Oakland, California • San Diego, California + 17 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Loveland",
          "state": "Colorado"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00374413"
    },
    {
      "nct_id": "NCT01055574",
      "title": "Physical Capability Outcomes After Single-Level PD-L vs Single-Level ALIF: a Multi-Center Clinical Trial",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Physical Capability Outcomes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Gundersen Lutheran Medical Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 45,
      "start_date": "2009-10",
      "completion_date": "2012-01",
      "has_results": false,
      "last_update_posted_date": "2011-09-09",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 6,
      "location_summary": "Denver, Colorado • Newark, Delaware • Tallahassee, Florida + 3 more",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Tallahassee",
          "state": "Florida"
        },
        {
          "city": "Marquette",
          "state": "Michigan"
        },
        {
          "city": "Plano",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01055574"
    },
    {
      "nct_id": "NCT01028300",
      "title": "Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "ProDisc™-L Total Disc Replacement (TDR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Synthes USA HQ, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 4,
      "start_date": "2010-04",
      "completion_date": "2011-03",
      "has_results": true,
      "last_update_posted_date": "2016-03-02",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01028300"
    },
    {
      "nct_id": "NCT05701059",
      "title": "Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cervical Spondylosis With Myelopathy",
        "Cervical Radiculopathy",
        "Cervical Disc Herniation",
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "Cervical arthroplasty",
          "type": "PROCEDURE"
        },
        {
          "name": "Semi-Constrained Nuvasive Simplify",
          "type": "DEVICE"
        },
        {
          "name": "Unconstrained Biomet Zimmer Mobi-C",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 20,
      "start_date": "2023-05-01",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05701059"
    },
    {
      "nct_id": "NCT00931515",
      "title": "Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "NuBac",
          "type": "DEVICE"
        },
        {
          "name": "Prodisc-L",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pioneer Surgical Technology, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2009-02",
      "completion_date": "2012-12",
      "has_results": true,
      "last_update_posted_date": "2014-05-26",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 17,
      "location_summary": "Beverly Hills, California • Colton, California • Loma Linda, California + 13 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Colton",
          "state": "California"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00931515"
    },
    {
      "nct_id": "NCT04982835",
      "title": "M6-C Artificial Cervical Disc Two-Level IDE Pivotal Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cervical Disc Degenerative Disorder"
      ],
      "interventions": [
        {
          "name": "M6-C Artificial Cervical Disc",
          "type": "DEVICE"
        },
        {
          "name": "ACDF",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Orthofix Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 156,
      "start_date": "2021-07-26",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 21,
      "location_summary": "Phoenix, Arizona • Beverly Hills, California • Long Beach, California + 18 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04982835"
    },
    {
      "nct_id": "NCT00589797",
      "title": "Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "Activ-L Artificial Disc",
          "type": "DEVICE"
        },
        {
          "name": "ProDisc-L Total Disc Replacement or Charité Artificial Disc",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Aesculap Implant Systems",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 376,
      "start_date": "2007-01",
      "completion_date": "2017-01",
      "has_results": true,
      "last_update_posted_date": "2018-12-07",
      "last_synced_at": "2026-09-09T00:11:19.065Z",
      "location_count": 17,
      "location_summary": "La Jolla, California • Newport Beach, California • Rancho Cucamonga, California + 14 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Rancho Cucamonga",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00589797"
    }
  ]
}