{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee&page=29",
    "query": {
      "intervention": "Total knee",
      "page": 29
    },
    "page_size": 10
  },
  "pagination": {
    "page": 29,
    "page_size": 10,
    "total_count": 942,
    "total_pages": 95,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee&page=30&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee&page=28&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-14T12:15:59.822Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02926651",
      "title": "Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint Arthroplasty",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Anemia",
        "Arthritis",
        "Total Knee Arthroplasty",
        "Total Hip Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Conventional Oral TXA (Tranexamic Acid)",
          "type": "DRUG"
        },
        {
          "name": "Multi-Dose Oral TXA (Tranexamic Acid)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2016-10",
      "completion_date": "2017-07",
      "has_results": false,
      "last_update_posted_date": "2021-10-26",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02926651"
    },
    {
      "nct_id": "NCT00958945",
      "title": "Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Total Knee Arthroplasty",
        "Arthroplasty, Replacement, Hip"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Desert Orthopedic Center Medical Research Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 500,
      "start_date": "2009-09",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2009-08-14",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "Rancho Mirage, California",
      "locations": [
        {
          "city": "Rancho Mirage",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00958945"
    },
    {
      "nct_id": "NCT07199738",
      "title": "A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Inflammatory Arthritis",
        "Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis)",
        "Post-traumatic Arthritis"
      ],
      "interventions": [
        {
          "name": "Cemented CoCr",
          "type": "DEVICE"
        },
        {
          "name": "Cemented Oxinium",
          "type": "DEVICE"
        },
        {
          "name": "Cementless",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 144,
      "start_date": "2025-09-25",
      "completion_date": "2036-12",
      "has_results": false,
      "last_update_posted_date": "2026-08-06",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 4,
      "location_summary": "Newton, Massachusetts • New York, New York • Charleston, South Carolina + 1 more",
      "locations": [
        {
          "city": "Newton",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07199738"
    },
    {
      "nct_id": "NCT01041937",
      "title": "Total Knee Arthroplasty (TKA) Cemented Versus Cementless Tibial Prosthesis Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Post-traumatic Osteoarthritis",
        "Rheumatoid Arthritis"
      ],
      "interventions": [
        {
          "name": "Cemented Tibia",
          "type": "PROCEDURE"
        },
        {
          "name": "Cementless Tibia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 106,
      "start_date": "2009-12",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2019-01-08",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01041937"
    },
    {
      "nct_id": "NCT06636669",
      "title": "Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Prosthetic-joint Infection",
        "Dysbiosis"
      ],
      "interventions": [
        {
          "name": "Probiotic",
          "type": "DRUG"
        },
        {
          "name": "Standard of care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Boston Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 152,
      "start_date": "2025-08-15",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • New York, New York",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06636669"
    },
    {
      "nct_id": "NCT05859269",
      "title": "Methylprednisolone Taper After Total Knee Replacement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Knee Arthritis"
      ],
      "interventions": [
        {
          "name": "Methylprednisolone",
          "type": "DRUG"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 101,
      "start_date": "2023-10-16",
      "completion_date": "2025-07-23",
      "has_results": false,
      "last_update_posted_date": "2025-09-18",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 2,
      "location_summary": "Atlanta, Georgia • Tucker, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Tucker",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05859269"
    },
    {
      "nct_id": "NCT02911389",
      "title": "Home PT vs FORCE PT",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Home PT via web-based platform",
          "type": "OTHER"
        },
        {
          "name": "Home PT via paper manual",
          "type": "OTHER"
        },
        {
          "name": "outpatient PT",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Rothman Institute Orthopaedics",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2016-03",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2016-09-22",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02911389"
    },
    {
      "nct_id": "NCT01264588",
      "title": "The Effects of Topical Calcium Glycerophosphate on Surgical Wound Healing and Residual Scarring",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wound Healing",
        "Scarring"
      ],
      "interventions": [
        {
          "name": "Topical calcium glycerophosphate lotion",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "AkPharma Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "45 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2008-04",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2010-12-22",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "Egg Harbor, New Jersey",
      "locations": [
        {
          "city": "Egg Harbor",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01264588"
    },
    {
      "nct_id": "NCT02521103",
      "title": "Triathlon Tritanium Cone Augments Outcomes Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthroplasty",
        "Replacement",
        "Knee"
      ],
      "interventions": [
        {
          "name": "Triathlon Tritanium Cone Augments",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stryker Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 254,
      "start_date": "2015-08",
      "completion_date": "2028-03-31",
      "has_results": true,
      "last_update_posted_date": "2026-06-01",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 9,
      "location_summary": "Zephyrhills, Florida • Chicago, Illinois • Lexington, Kentucky + 6 more",
      "locations": [
        {
          "city": "Zephyrhills",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Novi",
          "state": "Michigan"
        },
        {
          "city": "Ypsilanti",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02521103"
    },
    {
      "nct_id": "NCT02638623",
      "title": "Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Lactated Ringer",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "West Virginia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 52,
      "start_date": "2015-10",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2020-11-20",
      "last_synced_at": "2026-10-14T12:15:59.822Z",
      "location_count": 1,
      "location_summary": "Morgantown, West Virginia",
      "locations": [
        {
          "city": "Morgantown",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02638623"
    }
  ]
}