{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee+arthroplasty+patients&page=2", "query": { "intervention": "Total knee arthroplasty patients", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 475, "total_pages": 48, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee+arthroplasty+patients&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Total+knee+arthroplasty+patients&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-05T10:01:43.233Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05429671", "title": "Antibiotic Loaded Cement After TKA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Total Knee Arthoplasty" ], "interventions": [ { "name": "total knee arthroplasty", "type": "PROCEDURE" }, { "name": "Tobramycin", "type": "DRUG" }, { "name": "Gentamicin", "type": "DRUG" }, { "name": "Antibiotic cement spacer", "type": "DEVICE" } ], "intervention_types": [ "PROCEDURE", "DRUG", "DEVICE" ], "sponsor": "Rothman Institute Orthopaedics", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 50, "start_date": "2022-06-20", "completion_date": "2023-11-30", "has_results": false, "last_update_posted_date": "2024-04-30", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05429671" }, { "nct_id": "NCT07796152", "title": "Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Knee Arthroplasty, Total", "Post Operative Pain, Acute", "Opioid Consumption, Postoperative" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" }, { "name": "Opioid standard care pain medicine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Endeavor Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 100, "start_date": "2026-09", "completion_date": "2028-01", "has_results": false, "last_update_posted_date": "2026-09-02", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Skokie, Illinois", "locations": [ { "city": "Skokie", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT07796152" }, { "nct_id": "NCT07138898", "title": "Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatic Disease" ], "interventions": [ { "name": "Methotrexate", "type": "DRUG" }, { "name": "Sulfasalazine", "type": "DRUG" }, { "name": "Hydroxychloroquine", "type": "DRUG" }, { "name": "Leflunomide", "type": "DRUG" }, { "name": "Azathioprine", "type": "DRUG" }, { "name": "Mycophenolate", "type": "DRUG" }, { "name": "Cyclosporine", "type": "DRUG" }, { "name": "Tacrolimus", "type": "DRUG" }, { "name": "Etanercept", "type": "DRUG" }, { "name": "Adalimumab", "type": "DRUG" }, { "name": "Golimumab", "type": "DRUG" }, { "name": "Certolizumab", "type": "DRUG" }, { "name": "Infliximab", "type": "DRUG" }, { "name": "Rituximab", "type": "BIOLOGICAL" }, { "name": "Belimumab", "type": "BIOLOGICAL" }, { "name": "Tocilizumab", "type": "BIOLOGICAL" }, { "name": "Anakinra", "type": "BIOLOGICAL" }, { "name": "Canakinumab", "type": "BIOLOGICAL" }, { "name": "Abatacept", "type": "BIOLOGICAL" }, { "name": "Secukinumab", "type": "BIOLOGICAL" }, { "name": "Ixekizumab", "type": "BIOLOGICAL" }, { "name": "Bimekizumab", "type": "BIOLOGICAL" }, { "name": "Ustekinumab", "type": "BIOLOGICAL" }, { "name": "Guselkumab", "type": "BIOLOGICAL" }, { "name": "Risankizumab", "type": "BIOLOGICAL" }, { "name": "Tofacitinib", "type": "DRUG" }, { "name": "Upadacitinib", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "NYU Langone Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": "2025-12-12", "completion_date": "2028-01", "has_results": false, "last_update_posted_date": "2026-07-09", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07138898" }, { "nct_id": "NCT01882751", "title": "In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Complications; Arthroplasty" ], "interventions": [ { "name": "Conformis CR Total Knee Replacement", "type": "DEVICE" }, { "name": "Off the Shelf", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Restor3D", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "40 Years to 70 Years" }, "enrollment_count": 66, "start_date": "2013-06", "completion_date": "2017-08", "has_results": false, "last_update_posted_date": "2023-10-25", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 2, "location_summary": "Knoxville, Tennessee", "locations": [ { "city": "Knoxville", "state": "Tennessee" }, { "city": "Knoxville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01882751" }, { "nct_id": "NCT00359151", "title": "Celebrex Total Knee Arthroplasty Study", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Osteoarthritis", "Pain" ], "interventions": [ { "name": "Celecoxib", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 22, "start_date": "2006-11", "completion_date": "2007-07", "has_results": false, "last_update_posted_date": "2021-03-03", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 7, "location_summary": "Aurora, Colorado • Englewood, Colorado • Chicago, Illinois + 3 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Englewood", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00359151" }, { "nct_id": "NCT01786577", "title": "Study To Analyze Memory/Thinking Problems In Older Adults After Surgery", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Post-Operative Cognitive Decline in Older Adults" ], "interventions": [ { "name": "Magnetic Resonance Imaging", "type": "OTHER" }, { "name": "Cognitive assessment testing", "type": "BEHAVIORAL" } ], "intervention_types": [ "OTHER", "BEHAVIORAL" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 147, "start_date": "2013-03-19", "completion_date": "2018-07-21", "has_results": false, "last_update_posted_date": "2019-07-08", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01786577" }, { "nct_id": "NCT05603832", "title": "A Phase 3 Study of F14 for Management of Pain Following Total Knee Replacement", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Post Operative Pain" ], "interventions": [ { "name": "F14", "type": "DRUG" }, { "name": "0.25 % Bupivacaine HCl", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Methocarbamol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Arthritis Innovation Corporation", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "45 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "45 Years to 80 Years" }, "enrollment_count": 151, "start_date": "2022-11-17", "completion_date": "2024-08-23", "has_results": false, "last_update_posted_date": "2025-12-18", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 7, "location_summary": "Little Rock, Arkansas • Tamarac, Florida • Tulsa, Oklahoma + 4 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Tamarac", "state": "Florida" }, { "city": "Tulsa", "state": "Oklahoma" }, { "city": "Bellaire", "state": "Texas" }, { "city": "Carrollton", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05603832" }, { "nct_id": "NCT07442981", "title": "Preoperative Dietary Fat Consumption and Baseline Inflammatory Markers", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Fat Consumption", "Inflammatory Markers" ], "interventions": [ { "name": "Inflammatory markers test in blood prior to surgery", "type": "DIAGNOSTIC_TEST" }, { "name": "Inflammatory markers test in CSF (cerebrospinal fluid)", "type": "DIAGNOSTIC_TEST" }, { "name": "MOCA test", "type": "DIAGNOSTIC_TEST" }, { "name": "CAM-3D", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 62, "start_date": "2025-03-25", "completion_date": "2026-01-30", "has_results": false, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT07442981" }, { "nct_id": "NCT06619340", "title": "EXPAREL IPSA Block in Knee Arthroplasty", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain, Postoperative", "Osteo Arthritis Knee" ], "interventions": [ { "name": "Exparel", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Campbell Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 10, "start_date": "2024-05-20", "completion_date": "2025-12-31", "has_results": false, "last_update_posted_date": "2024-10-01", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Germantown, Tennessee", "locations": [ { "city": "Germantown", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT06619340" }, { "nct_id": "NCT05428020", "title": "RCT Foley Catheter Study for Elective TJA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Urinary Retention", "Total Hip Arthroplasty", "Total Knee Arthroplasty" ], "interventions": [ { "name": "Indwelling foley catheter", "type": "DEVICE" }, { "name": "No foley catheter", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Rush University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 388, "start_date": "2020-11-16", "completion_date": "2022-11-15", "has_results": true, "last_update_posted_date": "2023-08-03", "last_synced_at": "2026-10-05T10:01:43.233Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05428020" } ] }