{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Transdermal+estradiol+patch",
    "query": {
      "intervention": "Transdermal estradiol patch"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 81,
    "total_pages": 9,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Transdermal+estradiol+patch&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-05T11:51:40.399Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00154180",
      "title": "Kronos Early Estrogen Prevention Study (KEEPS)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Menopause",
        "Arteriosclerosis"
      ],
      "interventions": [
        {
          "name": "Conjugated equine estrogens 0.45 mg/day",
          "type": "DRUG"
        },
        {
          "name": "Transdermal estradiol, 50 mcg/day",
          "type": "DRUG"
        },
        {
          "name": "Micronized progesterone, 200 mg/day x 12 d/month",
          "type": "DRUG"
        },
        {
          "name": "CEE , progesterone, estradiol patch or placebo for each",
          "type": "DRUG"
        },
        {
          "name": "CEE, progesterone, transdermal patch or the placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Kronos Longevity Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "42 Years",
        "maximum_age": "58 Years",
        "sex": "FEMALE",
        "summary": "42 Years to 58 Years · Female only"
      },
      "enrollment_count": 728,
      "start_date": "2005-09",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2009-09-14",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 9,
      "location_summary": "Phoenix, Arizona • San Francisco, California • New Haven, Connecticut + 6 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00154180"
    },
    {
      "nct_id": "NCT00870220",
      "title": "Initiating Transdermal Estradiol Therapy in Turner's Syndrome",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Turner's Syndrome"
      ],
      "interventions": [
        {
          "name": "Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "138 Months",
        "maximum_age": "13 Years",
        "sex": "FEMALE",
        "summary": "138 Months to 13 Years · Female only"
      },
      "enrollment_count": 1,
      "start_date": "2009-04",
      "completion_date": "2011-03",
      "has_results": false,
      "last_update_posted_date": "2014-03-11",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 3,
      "location_summary": "Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00870220"
    },
    {
      "nct_id": "NCT02475265",
      "title": "Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Anorexia Nervosa",
        "Osteoporosis"
      ],
      "interventions": [
        {
          "name": "estradiol 0.045 mg/levonorgestrel 0.015mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "25 Years to 50 Years · Female only"
      },
      "enrollment_count": 11,
      "start_date": "2015-07",
      "completion_date": "2018-07-30",
      "has_results": true,
      "last_update_posted_date": "2019-07-22",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02475265"
    },
    {
      "nct_id": "NCT00269620",
      "title": "PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Contraception"
      ],
      "interventions": [
        {
          "name": "ethinyl estradiol/etonogestrel vaginal ring",
          "type": "DRUG"
        },
        {
          "name": "ethinyl estradiol/norelgestromin transdermal contraceptive",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 500,
      "start_date": "2005-06",
      "completion_date": "2006-12",
      "has_results": false,
      "last_update_posted_date": "2008-10-21",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 10,
      "location_summary": "Los Angeles, California • Chicago, Illinois • Baltimore, Maryland + 7 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00269620"
    },
    {
      "nct_id": "NCT06610305",
      "title": "Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Transdermal estradiol",
          "type": "DRUG"
        },
        {
          "name": "Progesterone",
          "type": "DRUG"
        },
        {
          "name": "Transdermal placebo patch",
          "type": "DRUG"
        },
        {
          "name": "placebo capsule",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 75,
      "start_date": "2024-09-02",
      "completion_date": "2028-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-10-29",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06610305"
    },
    {
      "nct_id": "NCT00910637",
      "title": "Study Investigating the Efficacy and Safety of a Contraceptive Patch for 13 Cycles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Contraception"
      ],
      "interventions": [
        {
          "name": "Gestodene/EE Patch (BAY86-5016)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bayer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 1502,
      "start_date": "2009-05-01",
      "completion_date": "2010-12-13",
      "has_results": false,
      "last_update_posted_date": "2021-04-08",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 63,
      "location_summary": "Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 54 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Glendale",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Carmichael",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00910637"
    },
    {
      "nct_id": "NCT00361075",
      "title": "Midlife Cholesterol Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Menopause",
        "Postmenopause",
        "Premenopause",
        "Cardiovascular Disease"
      ],
      "interventions": [
        {
          "name": "transdermal estradiol patch (Vivelle), oral estrogen (Estrace), progesterone (Prometrium)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "47 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "47 Years to 55 Years · Female only"
      },
      "enrollment_count": 120,
      "start_date": "1998-07",
      "completion_date": "2005-05",
      "has_results": false,
      "last_update_posted_date": "2014-11-05",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Seattle, Washington",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00361075"
    },
    {
      "nct_id": "NCT03003949",
      "title": "The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Perimenopausal Disorder",
        "Stress, Emotional"
      ],
      "interventions": [
        {
          "name": "Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release",
          "type": "DRUG"
        },
        {
          "name": "Placebo Patch",
          "type": "DRUG"
        },
        {
          "name": "Progesterone Capsule",
          "type": "DRUG"
        },
        {
          "name": "Placebo Oral Capsule",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "45 Years to 60 Years · Female only"
      },
      "enrollment_count": 82,
      "start_date": "2017-01-24",
      "completion_date": "2020-05-10",
      "has_results": true,
      "last_update_posted_date": "2021-03-26",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 2,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03003949"
    },
    {
      "nct_id": "NCT04423068",
      "title": "Inpatient Adolescent Contraception",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Pregnancy Related",
        "Contraception",
        "Contraceptive Usage",
        "Contraception Behavior",
        "Pregnancy"
      ],
      "interventions": [
        {
          "name": "SexHealth II",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Contraceptive",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Children's Mercy Hospital Kansas City",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "21 Years",
        "sex": "FEMALE",
        "summary": "14 Years to 21 Years · Female only"
      },
      "enrollment_count": 25,
      "start_date": "2020-12-10",
      "completion_date": "2023-04-04",
      "has_results": false,
      "last_update_posted_date": "2023-04-05",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 1,
      "location_summary": "Kansas City, Missouri",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04423068"
    },
    {
      "nct_id": "NCT01181479",
      "title": "Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Contraception"
      ],
      "interventions": [
        {
          "name": "AG200-15 (cycles 1-13)",
          "type": "DRUG"
        },
        {
          "name": "Lessina crossover to AG200-15",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Agile Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "17 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "17 Years to 40 Years · Female only"
      },
      "enrollment_count": 1504,
      "start_date": "2010-08",
      "completion_date": "2012-03",
      "has_results": true,
      "last_update_posted_date": "2018-07-03",
      "last_synced_at": "2026-09-05T11:51:40.399Z",
      "location_count": 80,
      "location_summary": "Huntsville, Alabama • Mobile, Alabama • Chandler, Arizona + 77 more",
      "locations": [
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Green Valley",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01181479"
    }
  ]
}