{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Twice+daily+hypertonic+saline+%28HS%29", "query": { "intervention": "Twice daily hypertonic saline (HS)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-08T09:59:27.915Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02378467", "title": "Saline Hypertonic in Preschoolers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "7% Hypertonic Saline (HS)", "type": "DRUG" }, { "name": "0.9% Isotonic Saline (IS)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Washington, the Collaborative Health Studies Coordinating Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "5 Years", "sex": "ALL", "summary": "3 Years to 5 Years" }, "enrollment_count": 150, "start_date": "2015-03-01", "completion_date": "2018-08-31", "has_results": false, "last_update_posted_date": "2020-01-14", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 23, "location_summary": "Birmingham, Alabama • Palo Alto, California • Aurora, Colorado + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Palo Alto", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Orlando", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02378467" }, { "nct_id": "NCT06350461", "title": "Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Discontinuation of hypertonic saline (HS)", "type": "OTHER" }, { "name": "Continuation of hypertonic saline (HS)", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Nicole Hamblett", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 370, "start_date": "2020-08-25", "completion_date": "2022-07-11", "has_results": true, "last_update_posted_date": "2024-10-01", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 81, "location_summary": "Birmingham, Alabama • Anchorage, Alaska • Tucson, Arizona + 69 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Anchorage", "state": "Alaska" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06350461" }, { "nct_id": "NCT06242795", "title": "Hypertonic Saline in NCFB", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bronchiectasis", "Non-cystic Fibrosis Bronchiectasis" ], "interventions": [ { "name": "7% Hypertonic Saline via nebulization", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2024-10-23", "completion_date": "2026-06", "has_results": false, "last_update_posted_date": "2025-08-13", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 1, "location_summary": "Chapel Hill, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT06242795" }, { "nct_id": "NCT02343445", "title": "Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "P-1037", "type": "DRUG" }, { "name": "Hypertonic Saline", "type": "DRUG" }, { "name": "Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Parion Sciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "12 Years to 80 Years" }, "enrollment_count": 142, "start_date": "2015-04", "completion_date": "2016-02", "has_results": false, "last_update_posted_date": "2021-07-26", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 33, "location_summary": "Los Angeles, California • Gainesville, Florida • Miami, Florida + 30 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02343445" }, { "nct_id": "NCT02709109", "title": "A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "VX-371 + HS", "type": "DRUG" }, { "name": "Hypertonic saline", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Orkambi", "type": "DRUG" }, { "name": "VX-371", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Parion Sciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 147, "start_date": "2016-02", "completion_date": "2017-09", "has_results": true, "last_update_posted_date": "2021-07-29", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 30, "location_summary": "Little Rock, Arkansas • Oakland, California • Gainesville, Florida + 27 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Oakland", "state": "California" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02709109" }, { "nct_id": "NCT00546663", "title": "Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "inhaled 7% hypertonic saline (HS)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "CF Therapeutics Development Network Coordinating Center", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Months", "maximum_age": "30 Months", "sex": "ALL", "summary": "12 Months to 30 Months" }, "enrollment_count": 19, "start_date": "2007-09", "completion_date": "2008-07", "has_results": false, "last_update_posted_date": "2011-08-24", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 2, "location_summary": "Chapel Hill, North Carolina • Seattle, Washington", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00546663" }, { "nct_id": "NCT02871778", "title": "Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Primary Ciliary Dyskinesia" ], "interventions": [ { "name": "VX-371", "type": "DRUG" }, { "name": "Hypertonic Saline", "type": "DRUG" }, { "name": "Placebo (0.17% saline)", "type": "DRUG" }, { "name": "VX-371 + HS", "type": "DRUG" }, { "name": "Ivacaftor", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Parion Sciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 123, "start_date": "2016-08", "completion_date": "2018-11-20", "has_results": true, "last_update_posted_date": "2021-12-16", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 21, "location_summary": "Birmingham, Alabama • Palo Alto, California • Aurora, Colorado + 18 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Palo Alto", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02871778" }, { "nct_id": "NCT07696338", "title": "Rethinking Early Airway Clearence Therapies", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis (CF)" ], "interventions": [ { "name": "As-needed hypertonic saline (HS)", "type": "OTHER" }, { "name": "Twice daily hypertonic saline (HS)", "type": "OTHER" }, { "name": "As-needed dornase alfa (DA)", "type": "OTHER" }, { "name": "Daily dornase alfa (DA)", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Nicole Hamblett", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "16 Years", "sex": "ALL", "summary": "3 Years to 16 Years" }, "enrollment_count": 405, "start_date": "2026-09-15", "completion_date": "2030-02-28", "has_results": false, "last_update_posted_date": "2026-07-10", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 36, "location_summary": "Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 32 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Palo Alto", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07696338" }, { "nct_id": "NCT02950883", "title": "Saline Hypertonic in Preschoolers + CT", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Active Treatment Group 7% Hypertonic Saline", "type": "DRUG" }, { "name": "Control Group 0.9% Isotonic Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Washington, the Collaborative Health Studies Coordinating Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "5 Years", "sex": "ALL", "summary": "3 Years to 5 Years" }, "enrollment_count": 116, "start_date": "2015-03-24", "completion_date": "2021-06-25", "has_results": false, "last_update_posted_date": "2024-03-12", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 7, "location_summary": "Aurora, Colorado • Indianapolis, Indiana • St Louis, Missouri + 4 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT02950883" }, { "nct_id": "NCT00709280", "title": "Infant Study of Inhaled Saline in Cystic Fibrosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "7% Hypertonic Saline (HS)", "type": "DRUG" }, { "name": "0.9% Isotonic Saline (IS)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "CF Therapeutics Development Network Coordinating Center", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "4 Months", "maximum_age": "59 Months", "sex": "ALL", "summary": "4 Months to 59 Months" }, "enrollment_count": 321, "start_date": "2009-04", "completion_date": "2011-11", "has_results": false, "last_update_posted_date": "2013-02-12", "last_synced_at": "2026-10-08T09:59:27.915Z", "location_count": 28, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Palo Alto, California + 24 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Palo Alto", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00709280" } ] }