{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Two+layer+allograft",
    "query": {
      "intervention": "Two layer allograft"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T20:38:01.327Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05842057",
      "title": "Human Amnion Membrane Allograft and Early Return of Erectile Function After Radical Prostatectomy",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Prostate Cancer",
        "Erectile Dysfunction Following Radical Prostatectomy"
      ],
      "interventions": [
        {
          "name": "BioDFence G3 Placental Tissue Membrane",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Robot-Assisted Radical Prostatectomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "PROCEDURE"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "MALE",
        "summary": "40 Years to 80 Years · Male only"
      },
      "enrollment_count": 118,
      "start_date": "2023-08-24",
      "completion_date": "2028-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05842057"
    },
    {
      "nct_id": "NCT07046767",
      "title": "CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Foot Ulcer (DFU)",
        "Venous Leg Ulcer",
        "Wound; Foot"
      ],
      "interventions": [
        {
          "name": "IP1: BioLab Membrane Wrap Lite IP2: BioLab Tri-Membrane Wrap",
          "type": "OTHER"
        },
        {
          "name": "IP2: BioLab Tri-Membrane Wrap",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Capsicure, LLC",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 165,
      "start_date": "2025-10-01",
      "completion_date": "2026-07-20",
      "has_results": false,
      "last_update_posted_date": "2025-10-22",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 7,
      "location_summary": "Oxnard, California • Coral Gables, Florida • Miami, Florida + 4 more",
      "locations": [
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07046767"
    },
    {
      "nct_id": "NCT06342973",
      "title": "Horizontal Ridge Augmentation With Demineralized Bone Allograft Layered With Xenograft - a Prospective Clinical Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Alveolar Ridge Deficiency"
      ],
      "interventions": [
        {
          "name": "Xenograft and allograft",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Louisiana State University Health Sciences Center in New Orleans",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2024-03-27",
      "completion_date": "2025-10-15",
      "has_results": false,
      "last_update_posted_date": "2025-11-21",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 1,
      "location_summary": "New Orleans, Louisiana",
      "locations": [
        {
          "city": "New Orleans",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06342973"
    },
    {
      "nct_id": "NCT01680861",
      "title": "Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate Sodium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Transplant; Failure, Kidney"
      ],
      "interventions": [
        {
          "name": "Tacrolimus",
          "type": "DRUG"
        },
        {
          "name": "Everolimus",
          "type": "DRUG"
        },
        {
          "name": "Enteric Coated Mycophenolate Sodium (EC-MPS)",
          "type": "DRUG"
        },
        {
          "name": "Corticosteroids",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gaetano Ciancio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 32,
      "start_date": "2012-11",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2016-12-15",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01680861"
    },
    {
      "nct_id": "NCT02838784",
      "title": "Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Venous Ulcer",
        "Foot Ulcer, Diabetic"
      ],
      "interventions": [
        {
          "name": "Artacent Human Amniotic Membrane",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Tides Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 134,
      "start_date": "2016-09",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2017-10-13",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 7,
      "location_summary": "Arcadia, California • New Iberia, Louisiana • New Orleans, Louisiana + 4 more",
      "locations": [
        {
          "city": "Arcadia",
          "state": "California"
        },
        {
          "city": "New Iberia",
          "state": "Louisiana"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "Bellmore",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02838784"
    },
    {
      "nct_id": "NCT07701590",
      "title": "CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wound, Foot",
        "Diabetic Foot Ulcer (DFU)",
        "Venus Leg Ulcer"
      ],
      "interventions": [
        {
          "name": "Microlyte®",
          "type": "DEVICE"
        },
        {
          "name": "IP 1: Membrane Wrap - Hydro",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Capsicure, LLC",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 147,
      "start_date": "2026-06-22",
      "completion_date": "2026-12-20",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 7,
      "location_summary": "San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07701590"
    },
    {
      "nct_id": "NCT06485206",
      "title": "Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "One level Mobi-C and one level fusion",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Highridge Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "22 Years to 69 Years"
      },
      "enrollment_count": 97,
      "start_date": "2024-09-01",
      "completion_date": "2029-05",
      "has_results": false,
      "last_update_posted_date": "2025-01-27",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 2,
      "location_summary": "Sacramento, California • Southfield, Michigan",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Southfield",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06485206"
    },
    {
      "nct_id": "NCT07086443",
      "title": "Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Diabetic Foot Ulcer",
        "DFU",
        "Diabetic Foot Ulcer (DFU)",
        "Foot Ulcer Due to Type 1 Diabetes Mellitus",
        "Foot Ulcer Due to Type 2 Diabetes Mellitus",
        "Ulcer",
        "Ulcer Foot"
      ],
      "interventions": [
        {
          "name": "Activate™ Matrix",
          "type": "OTHER"
        },
        {
          "name": "AmnioDefend™ FT Matrix",
          "type": "OTHER"
        },
        {
          "name": "Palisade™ DM Matrix",
          "type": "OTHER"
        },
        {
          "name": "Enclose™ TL Matrix",
          "type": "OTHER"
        },
        {
          "name": "Sentry™ SL Matrix",
          "type": "OTHER"
        },
        {
          "name": "Shelter™ DM Matrix + SOC",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Sequence LifeScience, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 350,
      "start_date": "2025-07-11",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-05-19",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 1,
      "location_summary": "Monroeville, Pennsylvania",
      "locations": [
        {
          "city": "Monroeville",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07086443"
    },
    {
      "nct_id": "NCT04982835",
      "title": "M6-C Artificial Cervical Disc Two-Level IDE Pivotal Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cervical Disc Degenerative Disorder"
      ],
      "interventions": [
        {
          "name": "M6-C Artificial Cervical Disc",
          "type": "DEVICE"
        },
        {
          "name": "ACDF",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Orthofix Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 156,
      "start_date": "2021-07-26",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 21,
      "location_summary": "Phoenix, Arizona • Beverly Hills, California • Long Beach, California + 18 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04982835"
    },
    {
      "nct_id": "NCT01902056",
      "title": "Implant Placement and Simultaneous Soft Tissue Grafting With Single or Double Layers of Acellular Dermal Matrix",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Clinical Efficacy"
      ],
      "interventions": [
        {
          "name": "One layer allograft",
          "type": "PROCEDURE"
        },
        {
          "name": "Two layer allograft",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Louisville",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2012-11",
      "completion_date": "2013-06",
      "has_results": false,
      "last_update_posted_date": "2013-07-17",
      "last_synced_at": "2026-09-10T20:38:01.327Z",
      "location_count": 1,
      "location_summary": "Louisville, Kentucky",
      "locations": [
        {
          "city": "Louisville",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01902056"
    }
  ]
}