{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Unified+Protocol+%28UP%29",
    "query": {
      "intervention": "Unified Protocol (UP)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 31,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Unified+Protocol+%28UP%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-14T10:21:54.263Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03102008",
      "title": "Unified Protocol for Adolescents (UP-A) Change Processes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety Disorders",
        "Depression",
        "Obsessive-Compulsive Disorder",
        "Adolescent - Emotional Problem",
        "Emotional Disorder"
      ],
      "interventions": [
        {
          "name": "Unified Protocol for Emotional Disorders in Adolescents (UP-A)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "13 Years to 17 Years"
      },
      "enrollment_count": 9,
      "start_date": "2017-01-12",
      "completion_date": "2017-12-14",
      "has_results": false,
      "last_update_posted_date": "2018-11-27",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Coral Gables, Florida",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03102008"
    },
    {
      "nct_id": "NCT03408860",
      "title": "Isolating Mechanisms in the Treatment of Borderline Personality Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Borderline Personality Disorder"
      ],
      "interventions": [
        {
          "name": "Countering Emotional Behaviors Module from Unified Protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boston University Charles River Campus",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2017-10-15",
      "completion_date": "2020-08-30",
      "has_results": true,
      "last_update_posted_date": "2022-11-16",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03408860"
    },
    {
      "nct_id": "NCT04431856",
      "title": "CO-PARENT: COVID-19 - Parent Action in Response to Emotions and Needs for Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety",
        "Depression",
        "Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Unified Protocol for COVID-19 Parenting Stress (UP-COVID)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "SHG",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2020-05-15",
      "completion_date": "2020-11-17",
      "has_results": false,
      "last_update_posted_date": "2020-12-01",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04431856"
    },
    {
      "nct_id": "NCT04198597",
      "title": "Exploring Two Treatments for Misophonia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Misophonia"
      ],
      "interventions": [
        {
          "name": "Unified Protocol for Transdiagnostic Treatment of Emotional Disorders",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Process-based Cognitive Behavioral Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2020-09-11",
      "completion_date": "2022-11-21",
      "has_results": false,
      "last_update_posted_date": "2022-11-25",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04198597"
    },
    {
      "nct_id": "NCT04871100",
      "title": "Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety Disorder",
        "Posttraumatic Stress Disorder",
        "Hazardous Drinking"
      ],
      "interventions": [
        {
          "name": "Unified Protocol- Alcohol",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Usual care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2023-03-01",
      "completion_date": "2026-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-18",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04871100"
    },
    {
      "nct_id": "NCT04584879",
      "title": "Transdiagnostic Treatment Personalization",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety Disorders",
        "Depressive Disorder",
        "Post Traumatic Stress Disorder",
        "Obsessive-Compulsive Disorder"
      ],
      "interventions": [
        {
          "name": "Standard UP Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Capitalization UP Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Compensation UP Treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Shannon E. Sauer-Zavala",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2019-10-28",
      "completion_date": "2020-09-15",
      "has_results": false,
      "last_update_posted_date": "2020-10-14",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04584879"
    },
    {
      "nct_id": "NCT07483333",
      "title": "Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Trauma Exposure",
        "Trauma",
        "Trauma and Stressor Related Disorder",
        "Mental Health Functioning",
        "Chronic Medical Conditions",
        "Chronic Medical Condition",
        "Chronic Medical Illness",
        "Posttraumatic Stress Disorder PTSD",
        "Posttraumatic Stress Disorders",
        "Posttraumatic Stress Symptoms",
        "Posttraumatic Stress"
      ],
      "interventions": [
        {
          "name": "Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Structured Psychotherapy for Adolescents Responding to Chronic Stress - Individual",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Anthony Vesco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "8 Years to 18 Years"
      },
      "enrollment_count": 400,
      "start_date": "2026-07",
      "completion_date": "2029-09-29",
      "has_results": false,
      "last_update_posted_date": "2026-03-19",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07483333"
    },
    {
      "nct_id": "NCT05734313",
      "title": "Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes",
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Unified protocol for cognitive behavioral therapy (UP-CBT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Continuous Glucose Monitoring (CGM)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "Albert Einstein College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 94,
      "start_date": "2023-03-31",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-30",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • The Bronx, New York",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05734313"
    },
    {
      "nct_id": "NCT04365543",
      "title": "Treatment for Youth (Ages 8 to 16 Years Old) With Misophonia (U-HEAR)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Misophonia"
      ],
      "interventions": [
        {
          "name": "Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Psychoeducation and Relaxation Therapy (PRT)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "8 Years to 16 Years"
      },
      "enrollment_count": 124,
      "start_date": "2020-04-08",
      "completion_date": "2022-12",
      "has_results": false,
      "last_update_posted_date": "2020-04-28",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 2,
      "location_summary": "Coral Gables, Florida • St. Petersburg, Florida",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "St. Petersburg",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04365543"
    },
    {
      "nct_id": "NCT06158581",
      "title": "Comparing Two Different Emotion Therapies for Autistic Youth and Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Autism Spectrum Disorder"
      ],
      "interventions": [
        {
          "name": "The Emotion Awareness and Skills Enhancement Program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "The Unified Protocol",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "10 Years to 30 Years"
      },
      "enrollment_count": 470,
      "start_date": "2024-04-08",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-09-14T10:21:54.263Z",
      "location_count": 2,
      "location_summary": "Tuscaloosa, Alabama • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Tuscaloosa",
          "state": "Alabama"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06158581"
    }
  ]
}