{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=VX-548", "query": { "intervention": "VX-548" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 23, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=VX-548&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-02T14:07:28.358Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04977336", "title": "A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Pain" ], "interventions": [ { "name": "VX-548", "type": "DRUG" }, { "name": "HB/APAP", "type": "DRUG" }, { "name": "Placebo (matched to VX-548)", "type": "DRUG" }, { "name": "Placebo (matched to HB/APAP)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 274, "start_date": "2021-07-19", "completion_date": "2022-03-04", "has_results": true, "last_update_posted_date": "2025-06-25", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 12, "location_summary": "Sheffield, Alabama • Phoenix, Arizona • Anaheim, California + 9 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "Tarzana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04977336" }, { "nct_id": "NCT05455502", "title": "A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-548", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pain" ], "interventions": [ { "name": "VX-548", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 24, "start_date": "2022-07-13", "completion_date": "2022-09-17", "has_results": false, "last_update_posted_date": "2024-03-20", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT05455502" }, { "nct_id": "NCT06176196", "title": "Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Painful Lumbosacral Radiculopathy" ], "interventions": [ { "name": "VX-548", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 218, "start_date": "2023-12-13", "completion_date": "2024-10-16", "has_results": false, "last_update_posted_date": "2025-10-01", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 54, "location_summary": "Phoenix, Arizona • Bakersfield, California • Banning, California + 48 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Bakersfield", "state": "California" }, { "city": "Banning", "state": "California" }, { "city": "La Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06176196" }, { "nct_id": "NCT06820307", "title": "Evaluation of the Effect of Suzetrigine (SUZ) on the Pharmacokinetics of Oral Contraceptives in Healthy Female Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" }, { "name": "DRSP/EE", "type": "DRUG" }, { "name": "NGM/EE", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 50, "start_date": "2025-02-25", "completion_date": "2025-04-29", "has_results": false, "last_update_posted_date": "2025-05-29", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 1, "location_summary": "Tempe, Arizona", "locations": [ { "city": "Tempe", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT06820307" }, { "nct_id": "NCT07538570", "title": "Evaluation of Pain Treatment After Total Knee Arthroplasty", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 60, "start_date": "2026-04-24", "completion_date": "2027-01-30", "has_results": false, "last_update_posted_date": "2026-08-18", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 2, "location_summary": "Bellaire, Texas • Houston, Texas", "locations": [ { "city": "Bellaire", "state": "Texas" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07538570" }, { "nct_id": "NCT06628908", "title": "Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetic Peripheral Neuropathic Pain" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" }, { "name": "Placebo (matched to SUZ)", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Placebo (matched to Pregabalin)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1100, "start_date": "2024-10-01", "completion_date": "2027-05-31", "has_results": false, "last_update_posted_date": "2026-06-15", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 76, "location_summary": "Anniston, Alabama • Birmingham, Alabama • Daphne, Alabama + 68 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Daphne", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT06628908" }, { "nct_id": "NCT05818852", "title": "A Study to Evaluate the Effect of VX-548 on the QT/QTc Interval in Healthy Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pain" ], "interventions": [ { "name": "VX-548", "type": "DRUG" }, { "name": "Moxifloxacin", "type": "DRUG" }, { "name": "Moxifloxacin Placebo", "type": "DRUG" }, { "name": "VX-548 Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 72, "start_date": "2023-04-12", "completion_date": "2023-06-28", "has_results": false, "last_update_posted_date": "2024-03-20", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 2, "location_summary": "Lenexa, Kansas • Salt Lake City, Utah", "locations": [ { "city": "Lenexa", "state": "Kansas" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT05818852" }, { "nct_id": "NCT07378865", "title": "Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 12, "start_date": "2026-02-13", "completion_date": "2027-02-26", "has_results": false, "last_update_posted_date": "2026-05-13", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT07378865" }, { "nct_id": "NCT07231419", "title": "Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetic Peripheral Neuropathic Pain" ], "interventions": [ { "name": "Suzetrigine", "type": "DRUG" }, { "name": "Placebo (matched to SUZ)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 734, "start_date": "2025-11-21", "completion_date": "2027-04-06", "has_results": false, "last_update_posted_date": "2026-07-20", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 75, "location_summary": "Birmingham, Alabama • Mobile, Alabama • Glendale, Arizona + 71 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT07231419" }, { "nct_id": "NCT05553366", "title": "Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Pain" ], "interventions": [ { "name": "SUZ", "type": "DRUG" }, { "name": "HB/APAP", "type": "DRUG" }, { "name": "Placebo (matched to SUZ)", "type": "DRUG" }, { "name": "Placebo (matched to HB/APAP)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1075, "start_date": "2022-10-03", "completion_date": "2023-12-15", "has_results": true, "last_update_posted_date": "2025-08-01", "last_synced_at": "2026-09-02T14:07:28.358Z", "location_count": 21, "location_summary": "Sheffield, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 18 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Bakersfield", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05553366" } ] }