{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Valve+replacement&page=2",
    "query": {
      "intervention": "Valve replacement",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Valve+replacement&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T09:40:16.269Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04860765",
      "title": "COMPASSION S3 Post-Approval Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Complex Congenital Heart Defect",
        "Dysfunctional RVOT Conduit",
        "Pulmonary Valve Insufficiency",
        "Pulmonary Valve Degeneration",
        "Pulmonary Valve; Obstruction"
      ],
      "interventions": [
        {
          "name": "SAPIEN 3 THV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 150,
      "start_date": "2021-04-13",
      "completion_date": "2030-08",
      "has_results": false,
      "last_update_posted_date": "2026-02-03",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 19,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 15 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Oak Lawn",
          "state": "Illinois"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04860765"
    },
    {
      "nct_id": "NCT04433065",
      "title": "TTVR Early Feasibility Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tricuspid Regurgitation"
      ],
      "interventions": [
        {
          "name": "Intrepid™ TTVR System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Cardiovascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2020-10-20",
      "completion_date": "2031-08-26",
      "has_results": false,
      "last_update_posted_date": "2026-08-07",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 20,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 16 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04433065"
    },
    {
      "nct_id": "NCT01812174",
      "title": "On-X Heart Valve - 17mm Aortic and 23mm Mitral",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Valve Disease"
      ],
      "interventions": [
        {
          "name": "17mm aortic valve (On-X )",
          "type": "DEVICE"
        },
        {
          "name": "23mm mitral valve (On-X)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "On-X Life Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2011-11-18",
      "completion_date": "2018-12-07",
      "has_results": true,
      "last_update_posted_date": "2024-03-06",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 7,
      "location_summary": "Little Rock, Arkansas • Portland, Maine • Las Vegas, Nevada + 4 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Portland",
          "state": "Maine"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01812174"
    },
    {
      "nct_id": "NCT01835028",
      "title": "Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Echocardiography",
          "type": "OTHER"
        },
        {
          "name": "Computed tomography",
          "type": "OTHER"
        },
        {
          "name": "Magnetic resonance imaging",
          "type": "OTHER"
        },
        {
          "name": "Blood biomarkers",
          "type": "OTHER"
        },
        {
          "name": "Stress echocardiography",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Laval University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "21 Years to 90 Years"
      },
      "enrollment_count": 320,
      "start_date": "2002-06",
      "completion_date": "2024-01",
      "has_results": false,
      "last_update_posted_date": "2021-09-21",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 2,
      "location_summary": "Rochester, Minnesota • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01835028"
    },
    {
      "nct_id": "NCT02675114",
      "title": "PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "SAVR",
          "type": "PROCEDURE"
        },
        {
          "name": "SAPIEN 3 THV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 1000,
      "start_date": "2016-03",
      "completion_date": "2029-12",
      "has_results": true,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 68,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Burlingame, California + 59 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Burlingame",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02675114"
    },
    {
      "nct_id": "NCT05541679",
      "title": "Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Complete Heart Block",
        "High Degree Second Degree Atrioventricular Block",
        "Pacemaker-Induced Cardiomyopathy",
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Right ventricular septal pacing followed by left bundle branch area pacing",
          "type": "DEVICE"
        },
        {
          "name": "Left bundle branch area pacing followed by right ventricular septal pacing",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Main Line Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2022-12-28",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-12-10",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 4,
      "location_summary": "Overland Park, Kansas • Ridgewood, New Jersey • Philadelphia, Pennsylvania + 1 more",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        },
        {
          "city": "Ridgewood",
          "state": "New Jersey"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Wynnewood",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05541679"
    },
    {
      "nct_id": "NCT06506903",
      "title": "Avalus Ultra Post-Approval Study (PAS)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Disease"
      ],
      "interventions": [
        {
          "name": "Medtronic Avalus Ultra",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Cardiac Surgery",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 190,
      "start_date": "2024-11-20",
      "completion_date": "2026-11",
      "has_results": false,
      "last_update_posted_date": "2026-04-21",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 15,
      "location_summary": "Hartford, Connecticut • Gainesville, Florida • Atlanta, Georgia + 11 more",
      "locations": [
        {
          "city": "Hartford",
          "state": "Connecticut"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Marietta",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06506903"
    },
    {
      "nct_id": "NCT00705913",
      "title": "Randomized Sizing and Hemodynamic Study Mitroflow vs. Magna",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Disease"
      ],
      "interventions": [
        {
          "name": "Mitroflow Aortic Pericardial Heart Valve (CarboMedics)",
          "type": "DEVICE"
        },
        {
          "name": "Carpentier-Edwards Magna Tissue Valve",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sorin Group USA, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 368,
      "start_date": "2008-06",
      "completion_date": "2011-09",
      "has_results": false,
      "last_update_posted_date": "2012-01-09",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 10,
      "location_summary": "San Diego, California • Tampa, Florida • Kansas City, Kansas + 7 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Salisbury",
          "state": "Maryland"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00705913"
    },
    {
      "nct_id": "NCT03107897",
      "title": "Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Pre-habilitation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "WellSpan Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 35,
      "start_date": "2016-08-17",
      "completion_date": "2021-04-30",
      "has_results": false,
      "last_update_posted_date": "2023-06-09",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 1,
      "location_summary": "York, Pennsylvania",
      "locations": [
        {
          "city": "York",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03107897"
    },
    {
      "nct_id": "NCT03851068",
      "title": "Early Feasibility Study for the Foldax Tria Aortic Heart Valve",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Disease",
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Foldax Tria Aortic Valve",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Foldax, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2019-06-18",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2023-09-13",
      "last_synced_at": "2026-09-11T09:40:16.269Z",
      "location_count": 5,
      "location_summary": "Indianapolis, Indiana • Wichita, Kansas • Detroit, Michigan + 2 more",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Wichita",
          "state": "Kansas"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03851068"
    }
  ]
}