{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Vehicle+topical+ophthalmic+solution&page=4", "query": { "intervention": "Vehicle topical ophthalmic solution", "page": 4 }, "page_size": 10 }, "pagination": { "page": 4, "page_size": 10, "total_count": 77, "total_pages": 8, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Vehicle+topical+ophthalmic+solution&page=5&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Vehicle+topical+ophthalmic+solution&page=3&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-09T16:29:35.562Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03691662", "title": "A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 4 Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Glaucoma and Ocular Hypertension" ], "interventions": [ { "name": "DE-117 Ophthalmic Solution", "type": "DRUG" }, { "name": "Timolol Maleate Ophthalmic Solution 0.5%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Santen Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Months", "maximum_age": null, "sex": "ALL", "summary": "12 Months and older" }, "enrollment_count": 417, "start_date": "2018-09-27", "completion_date": "2019-10-23", "has_results": true, "last_update_posted_date": "2023-08-09", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 34, "location_summary": "Chandler, Arizona • Prescott, Arizona • Glendale, California + 29 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Prescott", "state": "Arizona" }, { "city": "Glendale", "state": "California" }, { "city": "Inglewood", "state": "California" }, { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03691662" }, { "nct_id": "NCT02405039", "title": "Study of EBI-005 in Dry Eye Disease (DED)", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "EBI-005", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eleven Biotherapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 188, "start_date": "2015-04", "completion_date": "2016-07", "has_results": false, "last_update_posted_date": "2015-06-04", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 12, "location_summary": "Birmingham, Alabama • Newport Beach, California • Hamden, Connecticut + 9 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Newport Beach", "state": "California" }, { "city": "Hamden", "state": "Connecticut" }, { "city": "New Albany", "state": "Indiana" }, { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT02405039" }, { "nct_id": "NCT03889886", "title": "Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "SDP-4 Ophthalmic Solution (0.1%)", "type": "DRUG" }, { "name": "SDP-4 Ophthalmic Solution (1.0%)", "type": "DRUG" }, { "name": "SDP-4 Ophthalmic Solution (3.0%)", "type": "DRUG" }, { "name": "Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Silk Technologies, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 305, "start_date": "2019-04-16", "completion_date": "2019-10-11", "has_results": true, "last_update_posted_date": "2022-09-02", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 26, "location_summary": "Azusa, California • Garden Grove, California • Mission Hills, California + 22 more", "locations": [ { "city": "Azusa", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Mission Hills", "state": "California" }, { "city": "Murrieta", "state": "California" }, { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03889886" }, { "nct_id": "NCT03414645", "title": "Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Dry Eye", "Graft-versus-host-disease", "Ocular Discomfort" ], "interventions": [ { "name": "CAM-101 10%", "type": "BIOLOGICAL" }, { "name": "Vehicle Control", "type": "BIOLOGICAL" }, { "name": "CAM-101 30%", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Cambium Bio Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 64, "start_date": "2018-05-01", "completion_date": "2020-02-20", "has_results": true, "last_update_posted_date": "2026-06-12", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 6, "location_summary": "Palo Alto, California • Boston, Massachusetts • Ann Arbor, Michigan + 3 more", "locations": [ { "city": "Palo Alto", "state": "California" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Ann Arbor", "state": "Michigan" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03414645" }, { "nct_id": "NCT04403763", "title": "Phase 1/2 Study of AGN-241622 in Healthy Participants and Participants With Presbyopia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Presbyopia" ], "interventions": [ { "name": "AGN-241622", "type": "DRUG" }, { "name": "Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "40 Years to 65 Years" }, "enrollment_count": 80, "start_date": "2020-07-27", "completion_date": "2022-12-05", "has_results": true, "last_update_posted_date": "2024-02-06", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 10, "location_summary": "Inglewood, California • Los Angeles, California • Mission Hills, California + 7 more", "locations": [ { "city": "Inglewood", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Mission Hills", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Miami Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04403763" }, { "nct_id": "NCT06164743", "title": "Phase 2: VVN461 Ophthalmic Solution for Post -Operative Ocular Inflammation After Cataract Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Inflammation" ], "interventions": [ { "name": "VVN461 Ophthalmic Solution 1.0%", "type": "DRUG" }, { "name": "VVN461 Ophthalmic Solution 0.5%", "type": "DRUG" }, { "name": "Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VivaVision Biotech, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 91, "start_date": "2024-01-11", "completion_date": "2024-05-15", "has_results": true, "last_update_posted_date": "2026-09-11", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 10, "location_summary": "Inglewood, California • Petaluma, California • Rancho Cordova, California + 7 more", "locations": [ { "city": "Inglewood", "state": "California" }, { "city": "Petaluma", "state": "California" }, { "city": "Rancho Cordova", "state": "California" }, { "city": "Grand Junction", "state": "Colorado" }, { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06164743" }, { "nct_id": "NCT07838506", "title": "Phase 3, Multi-Center, Randomized, Double-Masked, Placebo-Controlled Study Assessing the Safety and Efficacy of Urcosimod Ophthalmic Solution in Participants With Neuropathic Corneal Pain (NCP).", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Neuropathic Corneal Pain" ], "interventions": [ { "name": "Urcosimod ophthalmic solution is a preservative-free topical ophthalmic product; supplied in unit dose ampoules; administered QID for 12-weeks.", "type": "DRUG" }, { "name": "Vehicle Ophthalmic Solution", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Okyo Pharma Ltd", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 111, "start_date": "2026-09", "completion_date": "2027-10", "has_results": false, "last_update_posted_date": "2026-09-29", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT07838506" }, { "nct_id": "NCT02693119", "title": "A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Leber's Hereditary Optic Neuropathy" ], "interventions": [ { "name": "elamipretide (MTP-131) 1% topical ophthalmic solution", "type": "DRUG" }, { "name": "Vehicle topical ophthalmic solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Stealth BioTherapeutics Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 12, "start_date": "2016-03", "completion_date": "2019-12", "has_results": true, "last_update_posted_date": "2021-11-30", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 1, "location_summary": "Pasadena, California", "locations": [ { "city": "Pasadena", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02693119" }, { "nct_id": "NCT04324359", "title": "Study to See How Well an Eye Drop, SURF-201, Works and What Side Effects There Are in Cataract Surgery Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Post-surgical Ocular Inflammation", "Post-surgical Ocular Pain" ], "interventions": [ { "name": "SURF-201", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Surface Ophthalmics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 91, "start_date": "2020-03-03", "completion_date": "2020-11-20", "has_results": true, "last_update_posted_date": "2025-01-15", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 10, "location_summary": "Hemet, California • Murrieta, California • Brooksville, Florida + 7 more", "locations": [ { "city": "Hemet", "state": "California" }, { "city": "Murrieta", "state": "California" }, { "city": "Brooksville", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Stuart", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04324359" }, { "nct_id": "NCT05109702", "title": "A Study to Assess the Efficacy and Safety of Tanfanercept (HL036) Ophthalmic Solution in Participants With Dry Eye", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "0.25% Tanfanercept Ophthalmic Solution", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HanAll BioPharma Co., Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 260, "start_date": "2021-11-18", "completion_date": "2022-05-06", "has_results": true, "last_update_posted_date": "2023-10-23", "last_synced_at": "2026-10-09T16:29:35.562Z", "location_count": 10, "location_summary": "Phoenix, Arizona • Glendale, California • Newport Beach, California + 7 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Glendale", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Louisville", "state": "Kentucky" }, { "city": "Raynham", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05109702" } ] }