{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Very+Low+Nicotine+Cigarette&page=2",
    "query": {
      "intervention": "Very Low Nicotine Cigarette",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 49,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Very+Low+Nicotine+Cigarette&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Very+Low+Nicotine+Cigarette&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-02T08:09:35.010Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02250664",
      "title": "Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 775,
      "start_date": "2016-10",
      "completion_date": "2019-10",
      "has_results": true,
      "last_update_posted_date": "2022-12-01",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Burlington, Vermont",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02250664"
    },
    {
      "nct_id": "NCT03571724",
      "title": "A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Non-Menthol Very Low Nicotine Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Menthol Very Low Nicotine Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Subject's UB non-mentholated filtered cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Subject's UB mentholated filtered cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "22nd Century Group, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "26 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "26 Years to 65 Years"
      },
      "enrollment_count": 142,
      "start_date": "2018-06-28",
      "completion_date": "2019-03-08",
      "has_results": true,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 2,
      "location_summary": "Lincoln, Nebraska • High Point, North Carolina",
      "locations": [
        {
          "city": "Lincoln",
          "state": "Nebraska"
        },
        {
          "city": "High Point",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03571724"
    },
    {
      "nct_id": "NCT06747871",
      "title": "Opioids, Low Nicotine Cigarettes, and Chronic Pain",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Pain",
        "Tobacco Use",
        "Opioid Substitution Treatment"
      ],
      "interventions": [
        {
          "name": "Very Low Nicotine Cigarettes (VLNC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Normal Nicotine Cigarettes (NNC)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2025-04-15",
      "completion_date": "2027-07-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-09",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06747871"
    },
    {
      "nct_id": "NCT02599571",
      "title": "Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence",
        "ADHD"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Conventional nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 71,
      "start_date": "2016-03-30",
      "completion_date": "2019-09-12",
      "has_results": false,
      "last_update_posted_date": "2020-01-27",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 2,
      "location_summary": "Durham, North Carolina • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02599571"
    },
    {
      "nct_id": "NCT02228824",
      "title": "Very-Low Nicotine Cigarettes and Non-Daily Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "DRUG"
        },
        {
          "name": "Normal nicotine content cigarettes",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Saul Shiffman",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 312,
      "start_date": "2015-06",
      "completion_date": "2017-07-31",
      "has_results": true,
      "last_update_posted_date": "2018-10-31",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02228824"
    },
    {
      "nct_id": "NCT03185546",
      "title": "Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "NNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "VLNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "Moderate nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Low nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Tobacco Flavors",
          "type": "OTHER"
        },
        {
          "name": "Tobacco and non-tobacco e-liquid flavors",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 156,
      "start_date": "2018-08-06",
      "completion_date": "2020-03-13",
      "has_results": true,
      "last_update_posted_date": "2021-05-14",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 2,
      "location_summary": "Winston-Salem, North Carolina • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03185546"
    },
    {
      "nct_id": "NCT03559751",
      "title": "Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "VLN cigarettes (A)",
          "type": "OTHER"
        },
        {
          "name": "Usual Brand Cigarettes (B)",
          "type": "OTHER"
        },
        {
          "name": "Nicotine gum (C)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "22nd Century Group, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 66,
      "start_date": "2018-04-13",
      "completion_date": "2018-09-06",
      "has_results": false,
      "last_update_posted_date": "2020-03-26",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03559751"
    },
    {
      "nct_id": "NCT03943706",
      "title": "E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 0,
      "start_date": "2019-06-01",
      "completion_date": "2019-12-01",
      "has_results": false,
      "last_update_posted_date": "2020-12-19",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03943706"
    },
    {
      "nct_id": "NCT02232737",
      "title": "Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 775,
      "start_date": "2016-10-07",
      "completion_date": "2019-01-14",
      "has_results": true,
      "last_update_posted_date": "2022-12-07",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island • Burlington, Vermont",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02232737"
    },
    {
      "nct_id": "NCT06234722",
      "title": "Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use",
        "Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Very Low Nicotine Cigarette",
          "type": "DRUG"
        },
        {
          "name": "Reduced nicotine regulatory environment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Restriction on characterizing flavors in combustible nicotine products",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Restriction on characterizing flavors in noncombustible nicotine products",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Mikhail N Koffarnus",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 473,
      "start_date": "2024-08-16",
      "completion_date": "2028-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-15",
      "last_synced_at": "2026-10-02T08:09:35.010Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06234722"
    }
  ]
}