{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Very+Low+Nicotine+Cigarettes",
    "query": {
      "intervention": "Very Low Nicotine Cigarettes"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 49,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Very+Low+Nicotine+Cigarettes&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-22T23:02:27.323Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03559751",
      "title": "Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "VLN cigarettes (A)",
          "type": "OTHER"
        },
        {
          "name": "Usual Brand Cigarettes (B)",
          "type": "OTHER"
        },
        {
          "name": "Nicotine gum (C)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "22nd Century Group, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 66,
      "start_date": "2018-04-13",
      "completion_date": "2018-09-06",
      "has_results": false,
      "last_update_posted_date": "2020-03-26",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03559751"
    },
    {
      "nct_id": "NCT02250534",
      "title": "Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "44 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 44 Years · Female only"
      },
      "enrollment_count": 775,
      "start_date": "2016-10",
      "completion_date": "2019-10",
      "has_results": true,
      "last_update_posted_date": "2022-12-01",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Burlington, Vermont",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02250534"
    },
    {
      "nct_id": "NCT03194256",
      "title": "Evaluating New Nicotine Standards for Cigarettes - Project 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking, Cigarette",
        "Electronic Cigarettes"
      ],
      "interventions": [
        {
          "name": "Spectrum Research Cigarettes",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "15 Years to 20 Years"
      },
      "enrollment_count": 80,
      "start_date": "2018-09-01",
      "completion_date": "2022-11-30",
      "has_results": true,
      "last_update_posted_date": "2023-12-18",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03194256"
    },
    {
      "nct_id": "NCT06787937",
      "title": "Communicating About Nicotine Reduction in Cigarettes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Products",
        "Smoking Behavior",
        "Cigarette Use"
      ],
      "interventions": [
        {
          "name": "VLNC messages",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control message",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Georgia State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 1230,
      "start_date": "2025-09-11",
      "completion_date": "2029-01-31",
      "has_results": false,
      "last_update_posted_date": "2025-10-29",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 2,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06787937"
    },
    {
      "nct_id": "NCT07161050",
      "title": "Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking",
        "E-cigarette Use"
      ],
      "interventions": [
        {
          "name": "Nicotine Content",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Illegal cigarette price",
          "type": "BEHAVIORAL"
        },
        {
          "name": "E-cigarette price",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2025-12-01",
      "completion_date": "2026-10-07",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Roanoke, Virginia",
      "locations": [
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07161050"
    },
    {
      "nct_id": "NCT03916341",
      "title": "Smoking and Ventricular Repolarization",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sudden Cardiac Death",
        "Prolonged QTc Interval"
      ],
      "interventions": [
        {
          "name": "EC with nicotine",
          "type": "OTHER"
        },
        {
          "name": "EC without nicotine",
          "type": "OTHER"
        },
        {
          "name": "control",
          "type": "OTHER"
        },
        {
          "name": "TC with nicotine (own brand)",
          "type": "OTHER"
        },
        {
          "name": "research TC with very low level nicotine",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 110,
      "start_date": "2019-10-01",
      "completion_date": "2023-04-10",
      "has_results": false,
      "last_update_posted_date": "2023-10-04",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03916341"
    },
    {
      "nct_id": "NCT05707871",
      "title": "Cardiovascular Effects of Very Low Nicotine Content Cigarettes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "SPECTRUM cigarettes",
          "type": "DRUG"
        },
        {
          "name": "usual brand of Cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 49,
      "start_date": "2023-04-04",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05707871"
    },
    {
      "nct_id": "NCT02587312",
      "title": "Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Standard nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "19 Years",
        "sex": "ALL",
        "summary": "15 Years to 19 Years"
      },
      "enrollment_count": 70,
      "start_date": "2016-10-13",
      "completion_date": "2019-08-31",
      "has_results": false,
      "last_update_posted_date": "2022-10-27",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02587312"
    },
    {
      "nct_id": "NCT04228952",
      "title": "Metabolism of NNK in Japanese Americans",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Modified Natural American Spirit-Tan or Green cigarettes injected with labeled NNK",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Masonic Cancer Center, University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2020-09-01",
      "completion_date": "2025-04-14",
      "has_results": true,
      "last_update_posted_date": "2025-08-01",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Honolulu, Hawaii",
      "locations": [
        {
          "city": "Honolulu",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04228952"
    },
    {
      "nct_id": "NCT03311646",
      "title": "Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Normal nicotine content cigarettes (NNC, Baseline)",
          "type": "OTHER"
        },
        {
          "name": "Very low nicotine content (VLNC)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 31,
      "start_date": "2018-04-15",
      "completion_date": "2018-12-01",
      "has_results": true,
      "last_update_posted_date": "2020-01-28",
      "last_synced_at": "2026-09-22T23:02:27.323Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03311646"
    }
  ]
}