{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Xylitol&page=2",
    "query": {
      "intervention": "Xylitol",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Xylitol&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-24T18:16:20.231Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03945461",
      "title": "Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spondylosis",
        "Spondylolisthesis",
        "Neurogenic Claudication",
        "Foraminal Stenosis"
      ],
      "interventions": [
        {
          "name": "Chewing gum",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 50,
      "start_date": "2019-02-13",
      "completion_date": "2023-12-30",
      "has_results": false,
      "last_update_posted_date": "2024-04-26",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03945461"
    },
    {
      "nct_id": "NCT01310283",
      "title": "Caries Management by Risk Assessment in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "xylitol mints and fluoride varnish",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "9 Years",
        "sex": "ALL",
        "summary": "5 Years to 9 Years"
      },
      "enrollment_count": 120,
      "start_date": "2010-04",
      "completion_date": "2012-05",
      "has_results": false,
      "last_update_posted_date": "2012-11-14",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 2,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01310283"
    },
    {
      "nct_id": "NCT03480971",
      "title": "Treatment of Radiation and Cisplatin Induced Toxicities with Tempol",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mucositis",
        "Nephrotoxicity",
        "Ototoxicity"
      ],
      "interventions": [
        {
          "name": "Tempol",
          "type": "DRUG"
        },
        {
          "name": "Placebo Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Matrix Biomed, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2019-05-13",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2024-11-20",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 9,
      "location_summary": "La Jolla, California • Merced, California • San Francisco, California + 4 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Merced",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Santa Maria",
          "state": "California"
        },
        {
          "city": "Santa Maria",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03480971"
    },
    {
      "nct_id": "NCT00393055",
      "title": "Xylitol Adult Caries Trial (X-ACT)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "xylitol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "inactive lozenge",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "25 Years to 80 Years"
      },
      "enrollment_count": 709,
      "start_date": "2007-01",
      "completion_date": "2011-06",
      "has_results": false,
      "last_update_posted_date": "2011-09-12",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 3,
      "location_summary": "Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00393055"
    },
    {
      "nct_id": "NCT01468727",
      "title": "Study on Use of Xylitol-wipes to Prevent Dental Caries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "xylitol wipe",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "placebo wipe",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Months",
        "maximum_age": "35 Months",
        "sex": "ALL",
        "summary": "6 Months to 35 Months"
      },
      "enrollment_count": 88,
      "start_date": "2007-01",
      "completion_date": "2008-01",
      "has_results": false,
      "last_update_posted_date": "2011-11-16",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01468727"
    },
    {
      "nct_id": "NCT07210697",
      "title": "Orthodontic Pain Alleviation With Chewing Gum",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Orthodontic Appliances"
      ],
      "interventions": [
        {
          "name": "Xylitol Gum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "West Virginia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 60,
      "start_date": "2025-10",
      "completion_date": "2026-03",
      "has_results": false,
      "last_update_posted_date": "2025-10-07",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "Morgantown, West Virginia",
      "locations": [
        {
          "city": "Morgantown",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07210697"
    },
    {
      "nct_id": "NCT03219840",
      "title": "Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Gingivitis",
        "Plaque, Dental",
        "Periodontal Diseases"
      ],
      "interventions": [
        {
          "name": "Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum",
          "type": "DRUG"
        },
        {
          "name": "Xylitol only chewing gum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2017-10-18",
      "completion_date": "2018-09-08",
      "has_results": true,
      "last_update_posted_date": "2021-02-08",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03219840"
    },
    {
      "nct_id": "NCT01901250",
      "title": "Xylitol for Caries Prevention in Inner-City Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Xylitol gummy bears",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sugar free fiber gummy bears",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Oral health education",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Fluoride varnish",
          "type": "DEVICE"
        },
        {
          "name": "Dental sealant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "6 Years",
        "sex": "ALL",
        "summary": "5 Years to 6 Years"
      },
      "enrollment_count": 562,
      "start_date": "2007-08",
      "completion_date": "2011-12",
      "has_results": true,
      "last_update_posted_date": "2014-08-12",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01901250"
    },
    {
      "nct_id": "NCT04608773",
      "title": "Blinded Dry Mouth Spray Crossover Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Xerostomia",
        "Head and Neck Cancer",
        "Xerostomia Following Radiotherapy"
      ],
      "interventions": [
        {
          "name": "Remineralizing Extreme Dry Mouth Spray with Xylitol",
          "type": "OTHER"
        },
        {
          "name": "Alcohol-Free Moisturizing Dry Mouth Spray",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Jonas Johnson",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 129,
      "start_date": "2021-01-14",
      "completion_date": "2023-06-30",
      "has_results": true,
      "last_update_posted_date": "2024-02-01",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 2,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04608773"
    },
    {
      "nct_id": "NCT06799039",
      "title": "Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Inflammatory Bowel Disease (IBD)",
        "Clostridioides Difficile Infection"
      ],
      "interventions": [
        {
          "name": "Xylitol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 69,
      "start_date": "2026-09-01",
      "completion_date": "2031-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-16",
      "last_synced_at": "2026-09-24T18:16:20.231Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06799039"
    }
  ]
}