{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Zilebesiran", "query": { "intervention": "Zilebesiran" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 5, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-10T10:31:57.628Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07181109", "title": "Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "High Risk Cardiovascular Disease", "Hypertension", "High Cardiovascular Risk" ], "interventions": [ { "name": "Zilebesiran", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alnylam Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 11000, "start_date": "2025-09-22", "completion_date": "2030-09-30", "has_results": false, "last_update_posted_date": "2026-08-19", "last_synced_at": "2026-09-10T10:31:57.628Z", "location_count": 263, "location_summary": "Birmingham, Alabama • Fairhope, Alabama • Foley, Alabama + 209 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT07181109" }, { "nct_id": "NCT04936035", "title": "A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "ALN-AGT01", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alnylam Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 394, "start_date": "2021-07-07", "completion_date": "2024-12-05", "has_results": true, "last_update_posted_date": "2025-12-23", "last_synced_at": "2026-09-10T10:31:57.628Z", "location_count": 54, "location_summary": "Birmingham, Alabama • Tempe, Arizona • Beverly Hills, California + 44 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "La Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04936035" }, { "nct_id": "NCT07553442", "title": "A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "ALN-AGT01 RVR", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Zilebesiran", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alnylam Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 93, "start_date": "2026-04-27", "completion_date": "2028-10-01", "has_results": false, "last_update_posted_date": "2026-08-14", "last_synced_at": "2026-09-10T10:31:57.628Z", "location_count": 3, "location_summary": "Lake Forest, California • Tampa, Florida • Savannah, Georgia", "locations": [ { "city": "Lake Forest", "state": "California" }, { "city": "Tampa", "state": "Florida" }, { "city": "Savannah", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT07553442" }, { "nct_id": "NCT05103332", "title": "Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Indapamide", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Olmesartan", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Zilebesiran", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alnylam Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 663, "start_date": "2021-11-05", "completion_date": "2024-09-13", "has_results": true, "last_update_posted_date": "2025-11-03", "last_synced_at": "2026-09-10T10:31:57.628Z", "location_count": 74, "location_summary": "Mesa, Arizona • Tempe, Arizona • Bell Gardens, California + 62 more", "locations": [ { "city": "Mesa", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Bell Gardens", "state": "California" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05103332" }, { "nct_id": "NCT06272487", "title": "Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "High Cardiovascular Risk", "Hypertension" ], "interventions": [ { "name": "Zilebesiran", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alnylam Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 375, "start_date": "2024-02-29", "completion_date": "2025-12-01", "has_results": false, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-10T10:31:57.628Z", "location_count": 139, "location_summary": "Alexander City, Alabama • Daphne, Alabama • Foley, Alabama + 115 more", "locations": [ { "city": "Alexander City", "state": "Alabama" }, { "city": "Daphne", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT06272487" } ] }