{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=bupropion%2C+transdermal+nicotine+patch",
    "query": {
      "intervention": "bupropion, transdermal nicotine patch"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=bupropion%2C+transdermal+nicotine+patch&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-26T06:30:40.695Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02420015",
      "title": "Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Schizophrenia",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "cognitive-behavioral smoking cessation counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stay Quit Coach",
          "type": "BEHAVIORAL"
        },
        {
          "name": "SMS text messaging",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 35,
      "start_date": "2017-03-27",
      "completion_date": "2019-01-24",
      "has_results": true,
      "last_update_posted_date": "2019-07-10",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02420015"
    },
    {
      "nct_id": "NCT00218218",
      "title": "Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Schizophrenia and Disorders With Psychotic Features",
        "Tobacco Use Disorder",
        "Schizophrenia"
      ],
      "interventions": [
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "21 mg transdermal nicotine",
          "type": "DRUG"
        },
        {
          "name": "placebo patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 48,
      "start_date": "2002-06",
      "completion_date": "2005-02",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00218218"
    },
    {
      "nct_id": "NCT01990079",
      "title": "Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "PTSD",
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Smoking cessation counseling",
          "type": "OTHER"
        },
        {
          "name": "mobile contingency management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stay Quit Coach",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 15,
      "start_date": "2013-12",
      "completion_date": "2015-08",
      "has_results": false,
      "last_update_posted_date": "2026-05-18",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01990079"
    },
    {
      "nct_id": "NCT00625131",
      "title": "Nicotine Patch Pretreatment for Smoking Cessation in PTSD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Stress Disorders, Posttraumatic",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Cognitive Behavioral Therapy for Smoking Cessation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Bupropion Sustained Release (SR)",
          "type": "DRUG"
        },
        {
          "name": "Placebo patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 87,
      "start_date": "2008-05",
      "completion_date": "2013-03",
      "has_results": true,
      "last_update_posted_date": "2014-11-20",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00625131"
    },
    {
      "nct_id": "NCT00108537",
      "title": "Non-Nicotine Agents for Smoking Cessation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "bupropion and transdermal patch",
          "type": "DRUG"
        },
        {
          "name": "transdermal patch and nicotine inhaler",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": null,
      "start_date": "2003-10",
      "completion_date": "2005-09",
      "has_results": false,
      "last_update_posted_date": "2008-04-04",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00108537"
    },
    {
      "nct_id": "NCT04634071",
      "title": "Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Smoking Cessation",
        "Cancer, Treatment-Related"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Long-acting nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Low-intensity counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "High-intensity counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No nicotine replacement therapy",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Replacement Products",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Joseph Valentino, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 126,
      "start_date": "2021-01-12",
      "completion_date": "2026-01-02",
      "has_results": false,
      "last_update_posted_date": "2026-02-02",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 3,
      "location_summary": "Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky",
      "locations": [
        {
          "city": "Bowling Green",
          "state": "Kentucky"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Owensboro",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04634071"
    },
    {
      "nct_id": "NCT00132821",
      "title": "Impact of Smoking Cessation on Sleep - 5",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Tobacco Use Cessation",
        "Sleep Disorders"
      ],
      "interventions": [
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Placebo transdermal nicotine patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 59,
      "start_date": "2005-08",
      "completion_date": "2009-05",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Menlo Park, California",
      "locations": [
        {
          "city": "Menlo Park",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00132821"
    },
    {
      "nct_id": "NCT01456936",
      "title": "Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "varenicline tartrate",
          "type": "DRUG"
        },
        {
          "name": "bupropion hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Replacement Therapy Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 8144,
      "start_date": "2011-11",
      "completion_date": "2015-01",
      "has_results": true,
      "last_update_posted_date": "2016-06-10",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 77,
      "location_summary": "Mobile, Alabama • Phoenix, Arizona • Encino, California + 61 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Escondido",
          "state": "California"
        },
        {
          "city": "Imperial",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01456936"
    },
    {
      "nct_id": "NCT02050308",
      "title": "Web-based Smoking Cessation Program for Tribal College Students",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Internet-All Nations Breath of Life (I-ANBL)",
          "type": "OTHER"
        },
        {
          "name": "Honoring the Gift of Heart Health",
          "type": "OTHER"
        },
        {
          "name": "Nicotine gum, Patch, or Lozenge or Zyban® or Chantix®",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Won Choi, PhD, MPH",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 251,
      "start_date": "2015-05",
      "completion_date": "2019-03-31",
      "has_results": true,
      "last_update_posted_date": "2021-12-07",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 2,
      "location_summary": "Kansas City, Kansas • Pablo, Montana",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Pablo",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02050308"
    },
    {
      "nct_id": "NCT02869451",
      "title": "Mobile Contingency Management for Marijuana and Tobacco Cessation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking",
        "Marijuana Abuse"
      ],
      "interventions": [
        {
          "name": "bupropion",
          "type": "DRUG"
        },
        {
          "name": "transdermal nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Nicotine polacrilex",
          "type": "DRUG"
        },
        {
          "name": "nicotine lozenge",
          "type": "DRUG"
        },
        {
          "name": "counseling for marijuana and smoking cessation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "mobile contingency management",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 7,
      "start_date": "2016-08",
      "completion_date": "2017-05-17",
      "has_results": true,
      "last_update_posted_date": "2020-02-07",
      "last_synced_at": "2026-09-26T06:30:40.695Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02869451"
    }
  ]
}