{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=bupropion+%2B+nicotine+gum&page=2", "query": { "intervention": "bupropion + nicotine gum", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 31, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=bupropion+%2B+nicotine+gum&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=bupropion+%2B+nicotine+gum&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-08T02:40:11.581Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01592695", "title": "Tailored Tobacco Quitline for Rural Veterans", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cigarette Smoking" ], "interventions": [ { "name": "Nicotine replacement therapy - transdermal nicotine patch", "type": "DRUG" }, { "name": "Tailored behavioral intervention", "type": "BEHAVIORAL" }, { "name": "Tobacco quit line referral", "type": "BEHAVIORAL" }, { "name": "Nicotine replacement therapy - nicotine gum", "type": "DRUG" }, { "name": "Nicotine replacement therapy - nicotine lozenge", "type": "DRUG" }, { "name": "Bupropion Sustained Release", "type": "DRUG" }, { "name": "Varenicline", "type": "DRUG" }, { "name": "Combination pharmacotherapy - transdermal nicotine patch + nicotine gum", "type": "DRUG" }, { "name": "Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge", "type": "DRUG" }, { "name": "Combination pharmacotherapy - transdermal nicotine patch + bupropion", "type": "DRUG" }, { "name": "Alcohol use risk reduction", "type": "BEHAVIORAL" }, { "name": "Behavioral activation for the treatment of depression", "type": "BEHAVIORAL" }, { "name": "Behavioral management of post-cessation weight gain", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Iowa City Veterans Affairs Medical Center", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 63, "start_date": "2012-06", "completion_date": "2013-06", "has_results": true, "last_update_posted_date": "2019-08-02", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Iowa City, Iowa", "locations": [ { "city": "Iowa City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT01592695" }, { "nct_id": "NCT00086385", "title": "Maintaining Nonsmoking: Older Smokers - 1", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Tobacco Use Disorder" ], "interventions": [ { "name": "Nicotine polacrilex, Bupropion", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 403, "start_date": "2001-09", "completion_date": "2009-03", "has_results": true, "last_update_posted_date": "2015-03-23", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00086385" }, { "nct_id": "NCT02994082", "title": "Treating Smokeless Tobacco Use in Rural Veterans", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Smokeless Tobacco", "Nicotine Dependence" ], "interventions": [ { "name": "Tailored behavioral intervention", "type": "BEHAVIORAL" }, { "name": "Behavioral activation for elevated depressive symptoms", "type": "BEHAVIORAL" }, { "name": "Post-cessation weight gain management", "type": "BEHAVIORAL" }, { "name": "Alcohol use risk reduction", "type": "BEHAVIORAL" }, { "name": "Nicotine replacement therapy - transdermal nicotine patch", "type": "DRUG" }, { "name": "Nicotine replacement therapy - nicotine lozenge", "type": "DRUG" }, { "name": "Nicotine replacement therapy - nicotine gum", "type": "DRUG" }, { "name": "Bupropion sustained release", "type": "DRUG" }, { "name": "Varenicline", "type": "DRUG" }, { "name": "Combination nicotine replacement therapy", "type": "DRUG" }, { "name": "Combination nicotine replacement therapy + bupropion", "type": "DRUG" }, { "name": "Tobacco quit line", "type": "BEHAVIORAL" }, { "name": "Educational materials", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "Mark Vander Weg", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 123, "start_date": "2016-12", "completion_date": "2020-05", "has_results": false, "last_update_posted_date": "2019-07-24", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Iowa City, Iowa", "locations": [ { "city": "Iowa City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT02994082" }, { "nct_id": "NCT00320697", "title": "Smoking Relapse Prevention in Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia", "Schizoaffective Disorder", "Smokers" ], "interventions": [ { "name": "bupropion + nicotine patch + nicotine gum or lozenges", "type": "DRUG" }, { "name": "Placebo pill + placebo patch", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "North Suffolk Mental Health Association", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 25, "start_date": "2006-04", "completion_date": "2009-08", "has_results": false, "last_update_posted_date": "2016-09-27", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00320697" }, { "nct_id": "NCT01901848", "title": "CPT and Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Stress Disorders, Post-Traumatic", "Smoking" ], "interventions": [ { "name": "Cognitive Processing Therapy (CPT)", "type": "BEHAVIORAL" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "nicotine replacement therapy (NRT)", "type": "DRUG" }, { "name": "Integrated Care for Smoking Cessation (ICSC)", "type": "BEHAVIORAL" }, { "name": "smokefreeVET", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 69, "start_date": "2013-12-11", "completion_date": "2017-07-30", "has_results": true, "last_update_posted_date": "2018-09-11", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01901848" }, { "nct_id": "NCT04490057", "title": "A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Tobacco Use Cessation" ], "interventions": [ { "name": "Nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler", "type": "DRUG" }, { "name": "Varenicline or bupropion", "type": "DRUG" }, { "name": "Contingency Management", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 323, "start_date": "2020-07-27", "completion_date": "2025-10-24", "has_results": true, "last_update_posted_date": "2026-01-05", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 4, "location_summary": "Bridgeport, Connecticut • New Haven, Connecticut • Brooklyn, New York + 1 more", "locations": [ { "city": "Bridgeport", "state": "Connecticut" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Brooklyn", "state": "New York" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT04490057" }, { "nct_id": "NCT02420015", "title": "Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia", "Cigarette Smoking" ], "interventions": [ { "name": "Nicotine replacement therapy", "type": "DRUG" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "cognitive-behavioral smoking cessation counseling", "type": "BEHAVIORAL" }, { "name": "Mobile Contingency Management", "type": "BEHAVIORAL" }, { "name": "Stay Quit Coach", "type": "BEHAVIORAL" }, { "name": "SMS text messaging", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 35, "start_date": "2017-03-27", "completion_date": "2019-01-24", "has_results": true, "last_update_posted_date": "2019-07-10", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02420015" }, { "nct_id": "NCT01789710", "title": "Contingency Management for Smoking Cessation in Homeless Smokers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Smoking", "Homeless Persons" ], "interventions": [ { "name": "Bupropion", "type": "DRUG" }, { "name": "Nicotine replacement therapy", "type": "DRUG" }, { "name": "Contingency Management", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 25, "start_date": "2013-01", "completion_date": "2014-09", "has_results": false, "last_update_posted_date": "2026-05-04", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01789710" }, { "nct_id": "NCT07835555", "title": "Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Tobacco Use Disorder/Cigarette Smoking", "HIV" ], "interventions": [ { "name": "nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion", "type": "DRUG" }, { "name": "Multi-target Contingency Management", "type": "BEHAVIORAL" }, { "name": "Teamlet booster", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 794, "start_date": "2027-09-30", "completion_date": "2031-09-30", "has_results": false, "last_update_posted_date": "2026-09-23", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 5, "location_summary": "Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more", "locations": [ { "city": "Bridgeport", "state": "Connecticut" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Jersey City", "state": "New Jersey" }, { "city": "Paterson", "state": "New Jersey" }, { "city": "Brooklyn", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07835555" }, { "nct_id": "NCT01309217", "title": "Dissemination of Tobacco Tactics for Hospitalized Smokers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Smoking Cessation" ], "interventions": [ { "name": "Tobacco Tactics Intervention", "type": "BEHAVIORAL" }, { "name": "Usual Care", "type": "OTHER" } ], "intervention_types": [ "BEHAVIORAL", "OTHER" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1528, "start_date": "2011-07", "completion_date": "2014-03", "has_results": false, "last_update_posted_date": "2014-11-18", "last_synced_at": "2026-10-08T02:40:11.581Z", "location_count": 6, "location_summary": "Grand Rapids, Michigan • Livonia, Michigan • Muskegon, Michigan + 2 more", "locations": [ { "city": "Grand Rapids", "state": "Michigan" }, { "city": "Livonia", "state": "Michigan" }, { "city": "Muskegon", "state": "Michigan" }, { "city": "Muskegon", "state": "Michigan" }, { "city": "Oakland", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01309217" } ] }